Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
WADIH ARAP · RBHS -CANCER INSTITUTE OF NEW JERSEY · 2019 · $623,916 — ABSTRACT Eight percent of patients diagnosed with prostate cancer progress to lethal metastatic disease. Development of resistance to androgen-deprivation therapy and eventually, to last line chemotherapeutics such as enzalutamide (ENZ), contribute to lethal, metastatic prostate cancer. While intere…
Jinjun Shi · BRIGHAM AND WOMEN'S HOSPITAL · 2019 · $526,391 — DESCRIPTION (provided by applicant): Given the capability of modulating individual gene expression in tumor cells, RNA agents such as small interfering RNA (siRNA) and messenger RNA (mRNA) have demonstrated tremendous potential in revealing the functionality of specific gene alterations and ena…
PHILIP J SANTANGELO · UNIVERSITY OF WISCONSIN-MADISON · 2019 · $385,366 — DESCRIPTION (provided by applicant): Human respiratory syncytial virus (hRSV) is the leading cause of viral pneumonia, bronchiolitis, respiratory failure, mechanical ventilation, and viral death in infants in the USA and worldwide. There are no effective vaccines for hRSV disease. In order to i…
Jae K Lee · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2019 · $481,810 — PROJECT SUMMARY/ABSTRACT After spinal cord injury (SCI), the injury site is filled with cellular debris, especially myelin debris that creates a very unique lipid-dense environment. Macrophages are the predominant phagocyte that are responsible for debris-clearance, but this process is not only inef…
Robert J Freishtat · CHILDREN'S RESEARCH INSTITUTE · 2019 · $188,112 — Abstract India has the highest prevalence of diabetes in the world (71 million patients in 2015) and is home to the largest number of low birth weight (LBW) infants (6-8 million per year). At first glance, these may seem unrelated. However, the association between birthweight and eventual risk of di…
Timothy R Donahue · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2019 · $433,388 — DESCRIPTION (provided by applicant): Nanocarriers that circumvent the stromal barrier in pancreatic ductal adenocarcinoma (PDAC) to allow (i) ratiometric control of a synergistic gemcitabine (GEM)/paclitaxel PTX) combination, (ii) overcome rate limiting steps in gemcitabine (GEM) metabolism, an…
NIGEL W BUNNETT · NEW YORK UNIVERSITY · 2019 · $282,990 — PROJECT SUMMARY This proposal examines the mechanisms by which G protein-coupled receptors (GPCRs) signal pain. Chronic pain is a hallmark of disease, a side effect of therapy, and a major cause of suffering. Although GPCRs mediate all aspects of nociception and are major therapeutic targets, the me…
Stephen Leppla · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2019 · $971,268 — We previously re-engineered the anthrax toxin proteins to produce a highly specific anti-angiogenic cancer therapeutic, able to strongly repress tumor growth in mouse models. This was achieved by modifying protective antigen (PA) so that its activation and toxicity require the presence of two protea…
TIMOTHY J. WILKIN · WEILL MEDICAL COLL OF CORNELL UNIV · 2019 · $1,089,913 — Clinical Trials Program Project Summary/Abstract The overall goal of the proposal is to advance prevention interventions for HPV-associated cancers occurring among men and women living with HIV in Latin America and the Caribbean (LAC). We are focusing on prevention of two HPV-associated cancers, or…
Hui-Kuan Lin · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2019 · $93,518 — The major goals of the newly formed Signaling and Biotechnology (SBT) Program are to understand the mechanisms underlying cancer pathogenesis and resistance to therapy and to use this knowledge to develop new technologies leading to more effective strategies for improved detection and treatment of c…
MARY A WILSON · HUGO W. MOSER RES INST KENNEDY KRIEGER · 2019 · $175,337 — No abstract provided…
Hui-Kuan Lin · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2019 · $5,639 — The major goals of the newly formed Signaling and Biotechnology (SBT) Program are to understand the mechanisms underlying cancer pathogenesis and resistance to therapy and to use this knowledge to develop new technologies leading to more effective strategies for improved detection and treatment of c…
Olga Gursky · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 · $427,652 — PROJECT SUMMARY / ABSTRACT The overall goal of this grant has been to understand in molecular details the action of apolipoproteins (apos) and lipoproteins in health and disease. The current focus is on human apoA-I, the major protein of plasma high-density lipoproteins (HDL, a.k.a. good cholesterol…
NURAN ERCAL · MISSOURI UNIVERSITY OF SCIENCE & TECHNOLOGY · 2019 · $387,500 — Project Summary/ Abstract Surgery is the only effective treatment for cataract, the most common cause of blindness worldwide. Although cataract surgery is routine and generally considered safe, it is costly and carries risks of serious complications (e.g., capsular opacification or rupture). Thus, t…
BABU L TEKWANI · SOUTHERN RESEARCH INSTITUTE · 2019 · $742,840 — PROJECT SUMMARY/ABSTRACT Development of dormant hypnozoites in the hepatic tissues, which may cause malaria relapse weeks to months after the initial infection, poses the major challenge for treatment & control of vivax malaria. 8- Aminoquinolines (8-AQs) are the only antimalarial drugs active agai…
Elliot Chaikof · BETH ISRAEL DEACONESS MEDICAL CENTER · 2019 · $796,846 — Project Summary New in vivo delivery technologies are urgently needed that enable selective genome editing of somatic cells without the limitations of existing viral delivery systems or lipid nanoparticles. We propose to develop two complementary strategies. First, by tethering Cas9 and base editor…
Gregory J Dodge · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2019 · $61,226 — Abstract: This project aims to expand the mechanistic understanding of the initial membrane-associated steps of bacterial glycoconjugate biosynthesis. Membrane protein structures are critically underrepresented in the protein data bank (PDB), and remain difficult targets for purification, character…
Subhash C. Chauhan · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · 2019 · $196,478 — The long-term goal of the proposed research proposal is to develop a targeted paclitaxel nanotherapy that can be used for the treatment of pancreatic cancer (PanCa) in combination with Gemcitabine (GEM). Although many conventional and combinational chemotherapies exist to treat PanCa, significant si…
NIGEL W BUNNETT · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2019 · $67,010 — PROJECT SUMMARY This proposal examines the mechanisms by which G protein-coupled receptors (GPCRs) signal pain. Chronic pain is a hallmark of disease, a side effect of therapy, and a major cause of suffering. Although GPCRs mediate all aspects of nociception and are major therapeutic targets, the me…
ZHENG-RONG LU · CASE WESTERN RESERVE UNIVERSITY · 2019 · $356,444 — The goal of this project is to develop smart dual-targeted lipid ECO/siRNA self-assembly nanoparticles to target oncogenic long non-coding RNAs (lncRNAs) as a novel therapy to treat metastatic and drug-resistant triple negative breast cancer (TNBC). Metastasis and drug resistance are the main causes…