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9873 documents

SOS:BIO - Assessing U.S. Biosafety and Biosecurity Compliance for Potential Pandemic Pathogen Research and Dual Use Research of Concern

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

David Gillum · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2024 · $285,994 — understanding of biosafety and biosecurity personnel and scientific researchers (a specialized part of the U.S. scientific workforce) with oversight responsibilities or research involving Potential Pandemic Pathogens (PPPs) and Dual Use Research of Concern (DURC) in various sectors (academic, indust…

CCR, LGI, Flow Cytometry Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Ferenc Livak · DIVISION OF BASIC SCIENCES - NCI · 2024 · $1,450,610 — The mission of the CCR LGI Flow Cytometry Core in Building 37 (FC37) is to offer up-to-date instrumentation and technical expertise to CCR investigators to assist cancer research. The core provides full-scale, state-of-the-art flow cytometry services including analytical sample acquisition, data ana…

The Effects of Prior Checkpoint Inhibitor (CPI) Therapy on Mouse Hepatitis Coronavirus Induced Pneumonia

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Parizad Torabi-Parizi · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2024 · $460,497 — Coronavirus disease 19 (COVID-19) is a rapidly growing health threat in the United States with a fatality rate ten times greater than with seasonal influenza. The virus is highly transmissible and has rapidly infected large numbers of people in China, in several European countries, and now in the US…

Facility Management, Maintenance and Operation Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

ELIZABETH ANN FITZPATRICK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2024 · $882,711 — The University of Tennessee Health Science Center (UTHSC) Regional Biocontainment Laboratory (RBL) provides a vast array of services that support the discovery and development of countermeasures for biodefense and emerging infectious agents with unmet medical needs. Central to this mission is the su…

CORE 3: Environmental Health and Biosafety Regulations and Requirements

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Kevin Michael Tuohey · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $1,953,496 — Core 3: Environmental Health and Biosafety Regulations and Requirements Abstract The Environmental Health and Biosafety Regulations and Requirements (EHBRR) Core includes three components: Environmental Health and Safety, Emergency Management, and Occupational Medicine. The Core is integrated with c…

Colombia-U.S. Fogarty training program on the impact of emerging zoonotic and vector-borne diseases in acute undifferentiated febrile illnesses

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Patricia Veronica Aguilar · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $297,388 — Abstract Non-malarial acute undifferentiated febrile illnesses (AUFIs) are significant causes of morbidity and mortality in Latin America, and the incidence of dengue-like illness has increased dramatically in recent years. As in most low-and middle-income countries, only a handful of “dengue” cases…

Optimizing Ridaifen-B analogs as potential therapeutics for Ebola viruses

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Lijun Rong · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $787,393 — Summary Ebola virus disease (EVD) is caused by an infection with a group of viruses within the genus Ebolavirus. There are at least five species of Ebolavirus, Ebola virus (Zaire, EBOV), Ebola Sudan (SUDV), Bundibugyo virus (BDBV), Reston virus and Tai Forest virus (TAFV). Infections with these viru…

Balance Dysfunction Induced by Lassa Virus Infection

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Tomoko Makishima · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $647,643 — PROJECT SUMMARY/ABSTRACT Lassa virus (LASV) infection causes Lassa Fever (LF), a hemorrhagic fever endemic to West Africa. Up to 30% of LASV infection survivors develop sudden onset hearing loss after clearing the initial acute disease, and in some cases also develop dizziness and imbalance, similar…

Tropical and Emerging Infectious Diseases for the Clinician and Translational Investigator

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

SUSAN Leslie Favrot MCLELLAN · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $6,000 — The NIH has long recognized the steady decline in the physician-scientist workforce. We have great concern over the critical shortage of physician-scientists in the field of Infectious Disease. We are equally concerned about assuring the next generation of leaders needed to combat the emergence of n…

Modernization of high and maximum containment research facilities at the National Emerging Infectious Diseases Laboratories (NEIDL) to meet current and future national research priorities

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Nancy Jean Sullivan · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $7,541,758 — PROJECT SUMMARY/ABSTRACT The National Emerging Infectious Diseases Laboratories (NEIDL) at Boston University (BU) was established to generate essential information about new and reemerging infectious pathogens and the diseases they cause, to facilitate development of vaccines, therapeutics, and diag…

Viral factors responsible for Lassa virus pathogenicity

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Junki Maruyama · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $249,000 — Lassa virus (LASV) is endemic in West African countries and causes outbreaks of LF annually. Although LASV is one of the most alarming pathogens from a public health perspective, there are few effective vaccines or therapeutics against LF. LASV must be handled at biosafety level 4 (BSL-4), due to …

Center on Emerging and Zoonotic Infectious Diseases

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Juergen A Richt · KANSAS STATE UNIVERSITY · 2024 · $2,256,646 — Overall Project Summary: This COBRE application will form a unique research center on Emerging and Zoonotic Infectious Diseases (EZID). Four primary research projects bridge areas of excellence in the Infectious Diseases programs at Kansas State University (KSU) within the Colleges of Arts and Scien…

Project 2

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Kristian Graugaard Andersen · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $642,549 — Project Summary - Project 2 The objective of Project 2 is to investigate the complex interplay of virus genetics and host immunity in determining epidemiology and outcome of infection with Lassa virus, Ebola virus, and SARS-CoV-2. Our central hypothesis is that both host and virus factors play key r…

Contributions of Ebola and Marburg virus VP30 and VP24 proteins to viral RNA synthesis, assembly and egress

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Christopher F Basler · WASHINGTON UNIVERSITY · 2024 · $414,434 — RP02 Project Summary/Abstract for Contributions of Ebola and Marburg virus VP30 and VP24 proteins to viral RNA synthesis, assembly and egress Marburg virus (MARV) and Ebola virus (EBOV) are deadly emerging viruses of the filovirus family. Major gaps remain in our understanding as to how filoviral-fi…

Zeiss LSM 980 Airyscan 2 laser scanning confocal microscope

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Neal Mathew Alto · UT SOUTHWESTERN MEDICAL CENTER · 2023 · $593,045 — PROJECT SUMMARY We are requesting funds to purchase a Zeiss LSM 980 Airyscan 2 confocal microscope for the Microbiology Live Cell Imaging Facility at UTSW Medical Center in Dallas, TX. The system will be dedicated to live cell imaging of Biosafety Level 2 (BSL2) pathogens, experiments that cannot be…

Nikon Multiphoton (MP) Imaging System

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

JAMES E CASSAT · VANDERBILT UNIVERSITY MEDICAL CENTER · 2023 · $857,209 — PROJECT SUMMARY / ABSTRACT Funds are requested to purchase a Nikon A1R Multiphoton (MP) Imaging System, to be integrated into the Vanderbilt Cell Imaging Shared Resource (CISR). Vanderbilt has a history of excellence in biomedical imaging, with outstanding facilities for human and live animal imagin…

Advancement of Vaccines and Therapies for Henipaviruses

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

CHRISTOPHER C BRODER · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2023 · $5,631,841 — Project Summary (OVERALL) The pathogenic henipaviruses (Nipah and Hendra) are distinguished among the paramyxoviruses by virtue of their uniquely broad tropism and impressive lethality. These viruses can infect animals across 6 orders of mammals, causing an often fatal disease in 11 species includin…

UTMB-Novartis Alliance for Pandemic Preparedness

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Thierry Diagana · UNIVERSITY OF TEXAS MED BR GALVESTON · 2023 · $18,849,015 — OVERALL – ABSTRACT Pandemic prevention and preparedness is a major scientific and societal priority that requires sustained and forward looking investments across governmental, non-governmental, academic and private sectors to develop an arsenal of countermeasures against the existential threat of v…

Optimizing Ridaifen-B analogs as potential therapeutics for Ebola viruses

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Lijun Rong · UNIVERSITY OF ILLINOIS AT CHICAGO · 2023 · $780,190 — Summary Ebola virus disease (EVD) is caused by an infection with a group of viruses within the genus Ebolavirus. There are at least five species of Ebolavirus, Ebola virus (Zaire, EBOV), Ebola Sudan (SUDV), Bundibugyo virus (BDBV), Reston virus and Tai Forest virus (TAFV). Infections with these viru…

Center on Emerging and Zoonotic Infectious Diseases

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Juergen A Richt · KANSAS STATE UNIVERSITY · 2023 · $2,260,087 — Overall Project Summary: This COBRE application will form a unique research center on Emerging and Zoonotic Infectious Diseases (EZID). Four primary research projects bridge areas of excellence in the Infectious Diseases programs at Kansas State University (KSU) within the Colleges of Arts and Scien…