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Principal Investigator: Juergen A Richt
Organization: KANSAS STATE UNIVERSITY
Fiscal Year: 2023
Award: $2,260,087
Funding agency: National Institute of General Medical Sciences
Overall Project Summary:
This COBRE application will form a unique research center on Emerging and Zoonotic Infectious Diseases
(EZID). Four primary research projects bridge areas of excellence in the Infectious Diseases programs at
Kansas State University (KSU) within the Colleges of Arts and Sciences and Veterinary Medicine. The
projects examine virulence factors and host-pathogen interactions of various pathogens, utilizing both basic and
translational approaches in in vitro systems and in animal models. The overarching goal of the EZID center is to
advance our understanding of emerging and zoonotic infectious diseases in the State of Kansas. Our goals are
also clearly aligned with NIH's strategic plan “Turning Discovery into Health”. Two research core facilities will
support the research projects and programs, an Animal Model/Pathology Core and a Molecular and Cellular
Biology Core, offering unique research infrastructure resources within KSU and the State of Kansas. The
success and growth of EZID will be enabled through various programs: (1) a faculty mentoring program that
will provide outstanding mentoring by nationally/internationally recognized mentors. The mentoring team will
implement individualized development plans, and support all aspects of research programs and grant application
processes to secure R01-level funding by the project leaders; (2) new faculty recruitment at KSU to ensure
the growth and sustainability of EZID, as well as productive use of core facilities; (3) a pilot and seed grant
program that will promote center growth by funding projects at universities within the State of Kansas; and (4)
a regional scientific network (RSN) that will provide inter-disciplinary and inter-institutional collaborations,
increased usage of core facilities, and access to additional core facilities and training opportunities. Initial
partners of the RSN include several COBREs within the State of Kansas and Nebraska, as well as the K-INBRE
center at the University of Kansas Medical School. The RSN will grow and expand both to other universities in
the region and to national COBRE centers working in the same mission space, thereby providing opportunities
for the rapid growth of research programs. These EZID programs will be the basis by which research productivity
is enabled and supported, helping to advance the overall success and reputation of the COBRE core projects,
pilot projects, post-doctoral and graduate student trainees, and associated EZID faculty. The EZID center will
host annual research symposia that will include participants from EZID projects and RSN members to showcase
and share research with investigators from inside and outside of the network, promoting the national and
international reputation of EZID.
Terms: <Achievement><Achievement Attainment><Address><Advisory Committees><Aging><Animal Diseases><Animal Model><Animal Models and Related Studies><Animals><Applications Grants><Area><Arts><Award><BSL-4 facility><BSL4 facility><Basic Research><Basic Science><COBRE><Cell Culture Techniques><Center of Biomedical Research Excellence><Centers of Research Excellence><Climate><Collaborations><Communicable Diseases><Core Facility><Development Plans><Disease><Disorder><EXTMR><Emerging Communicable Diseases><Emerging Infectious Diseases><Ensure><Environment><Extramural><Extramural Activities><Faculty><Faculty Recruitment><Funding><Future><Generalized Growth><Goals><Grant><Grant Proposals><Growth><Health><In Vitro><Incidence><Infectious Disease Pathway><Infectious Diseases><Infectious Diseases / Laboratory><Infectious Diseases Research><Infectious Disorder><Institution><Interdisciplinary Research><Interdisciplinary Study><International><Investigators><Island><Kansas><Laboratories><Mentors><Meteorological Climate><Microbe><Mission><Molecular and Cellular Biology><Multidisciplinary Collaboration><Multidisciplinary Research><NIH><National Institutes of Health><Nebraska><Participant><Pathogenicity Factors><Pathology><Pathway interactions><Persons><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D. student><PhD student><PhD. student><Pilot Projects><Plum><Postdoc><Postdoctoral Fellow><Process><Productivity><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Associate><Research Grants><Research Infrastructure><Research Institute><Research Personnel><Research Project Grants><Research Projects><Research Resources><Research Support><Researchers><Resources><Retirement><Science><Secure><Security><Strategic Planning><System><Task Forces><Tissue Growth><Training><Translational Research><Translational Science><United States National Institutes of Health><Universities><Veterinary Medicine><Viral><Virulence Factors><Work><Zoonoses><Zoonotic><Zoonotic Infection><advisory team><biosafety level 4 facility><cell culture><cell cultures><climatic><college><collegiate><conference><convention><doctoral student><faculty mentor><graduate student><improved><inter-institutional><interest><laboratory facility><medical college><medical schools><member><model of animal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><new vaccines><next generation therapeutics><next generation vaccines><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><novel vaccines><ontogeny><pathogen><pathway><pilot study><post-doc><post-doctoral><post-doctoral trainee><programs><rapid growth><recruit><recruit teachers><research associates><research facility><retirements><school of medicine><success><summit><symposia><symposium><synergism><teacher recruitment><training opportunity><translation research><translation strategy><translational approach><translational investigation><translational strategy>