Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
STEPHEN C JAMESON · UNIVERSITY OF MINNESOTA · 2021 · $192,543 — Summary Core B NME Mouse Core Our published studies suggest that mice with more physiological exposure to natural mouse microbes have immune systems that are a better match for the immune system in humans: In contrast to typical “clean” laboratory mice (which are maintained in barrier facilities to …
JORGE C BLANCO · SIGMOVIR BIOSYSTEMS, INC. · 2020 · $476,975 — The SARS-CoV-2 responsible for the Coronavirus disease 2019 (COVID-2019) outbreak represents a major public health threat that urgently requires development of a small animal model that can be used to test medical countermeasures. This supplement proposal is a logical extension of our parent grant, …
Christopher F Basler · GEORGIA STATE UNIVERSITY · 2020 · $779,568 — Project Summary Filoviruses, which include the ebolaviruses and marburgviruses, are non-segmented, negative-sense RNA viruses (NNSVs) that cause severe human disease. These viruses are of concern as emerging pathogens and as potential bioterrorism threats. Their importance and public health impact a…
Gaya K. Amarasinghe · WASHINGTON UNIVERSITY · 2020 · $2,554,916 — Abstract: Project Overview for Structural and Functional Studies of Ebola Virus RNA synthesis Ebolaviruses (EBOVs) are non-segmented negative-strand RNA viruses (NNSVs) and Category A Priority biodefense pathogens that cause frequent lethal hemorrhagic fever, including the devastating and ongoing ou…
Lijun Rong · CHICAGO BIOSOLUTIONS, INC. · 2020 · $961,660 — Ebola (EBOV) and Marburg (MARV) viruses belong to the Filoviridae family and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction after an incubation period of 4-14 days. Due to safety concerns, these viruses are designated as biosafety level 4 agents. Currently, there i…
Parizad Torabi-Parizi · CLINICAL CENTER · 2020 — Coronavirus disease 19 (COVID-19) is a rapidly growing health threat in the United States with a fatality rate ten times greater than with seasonal influenza. The virus is highly transmissible and has rapidly infected large numbers of people in China, in several European countries, and now in the US…
Ferenc Livak · DIVISION OF BASIC SCIENCES - NCI · 2020 · $1,192,401 — The core is equipped with six analytical instruments: a state-of-the-art BD FACSymphony A5 flow cytometer equipped with five lasers and the capacity to identify 27 fluorochromes also equipped with a high throughput sampler (HTS) attachment that accommodates 96-well plates to further increase the cap…
Iyadh Douagi · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $770,735 — In 2020 the project aims to use state of the art instrumentation to support the immediate research needs for COVID19 research in flow cytometry. We are particularly interested in using the CytoFLEX LX Flow Cytometry Analyzer. It is a highly capable flow cytometry analyzer equipped with 6 lasers an…
JILL E HUTCHCROFT · PURDUE UNIVERSITY · 2020 · $82,914 — Flow Cytometry Shared Resource (FC-SR) Project Summary The Purdue Flow Cytometry Shared Resource (FC-SR) provides advanced cell and particle analysis, cell sorting and single cell genomic capabilities to members of the Purdue University Center for Cancer Research (PCCR). The FC-SR has made major i…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2020 · $7,339,433 — OVERALL - Project Summary/Abstract Among viruses that cause disease in humans the filoviruses, Ebolavirus and Marburgvirus, stand out for their impressive lethality. These viruses are the most deadly human pathogens known to man with reported case fatality rates of up to 90%. The recent unprecedente…
CHRISTOPHER C BRODER · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2020 · $4,326,275 — Project Summary (OVERALL) The pathogenic henipaviruses (Nipah and Hendra) are distinguished among the paramyxoviruses by virtue of their uniquely broad tropism and impressive lethality. These viruses can infect animals across 6 orders of mammals, causing an often fatal disease in 11 species includin…
ROBERT A DAVEY · PURDUE UNIVERSITY · 2020 · $704,383 — A research team from Purdue University and Texas Biomedical Research Institute is in pursuit of important new approaches to validate the host V-ATPase. The project goal to define antiviral drug leads for diseases caused by Ebola and Marburg filoviruses. Many viral pathogens bind to specific factors …
Jae U Jung · CLEVELAND CLINIC LERNER COM-CWRU · 2020 · $619,413 — Project Summary/Abstract Severe fever with thrombocytopenia syndrome virus (SFTSV) listed in the World Health Organization 9 most dangerous pathogens is an emerging Phlebovirus in the Phenuiviridae family. Due to the lack of therapy and vaccine against SFTSV infection, there is a pressing need to u…
Corrie Ntiforo · UNIVERSITY OF TEXAS MED BR GALVESTON · 2020 · $467,803 — The overall goal of this project is to maintain the high containment research resources (infrastructure and facilities) required to conduct research that will facilitate the next generation therapeutics, diagnostics and vaccines for infectious diseases. The Galveston National Laboratory (GNL) at the…
JOANN M TUFARIELLO · GEORGIA STATE UNIVERSITY · 2020 · $209,214 — Summary This developmental project seeks to develop methods to dramatically boost immunogenicity of virus-like particle (VLP) vaccines. Ebola virus (EBOV) and Marburg virus (MARV) are members of the filovirus family of enveloped, negative-sense RNA viruses that causes outbreaks of severe human disea…
Yi Zeng · UNIVERSITY OF ARIZONA · 2020 · $84,066 — Project Summary / Abstract: Flow Cytometry Shared Resource (FCSR) The goal of the Flow Cytometry Shared Resource (FCSR), which has served investigators of the University of Arizona Cancer Center (UACC) for more than 25 years, is to offer UACC Members efficient and reliable flow cytometric service…
DAVID Branch MOODY · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $223,437 — The Metabolomics Core (B) is comprised of a Biosafety Level 3 suite for handling infectious samples, massively parallel detection of mycobacterial metabolites using Time of Flight mass spectrometry (Agilent Accurate Mass ToF 6230), specialized resources for identifying known mycobacterial compound…
Ron L Morales · BOSTON UNIVERSITY MEDICAL CAMPUS · 2020 · $1,650,526 — Environmental Health and Biosafety Regulations and Requirements (EH&S): Summary The Environmental Health and Biosafety Regulations and Requirements Core (EH&S) includes three components, Environmental Health and Safety, Emergency Management, and Occupational Medicine. The EH&S Core is integrated wit…
Ricardo Rajsbaum · UNIVERSITY OF TEXAS MED BR GALVESTON · 2020 · $395,000 — The most recent outbreak of Ebola virus (EBOV) in West Africa reached alarming numbers of infections and deaths, prompting extensive efforts to develop antiviral strategies; however, none have thus far been approved for use in humans. The development of antiviral drugs is mostly based on designing c…
Jay Kenneth Fisher · REDBUD LABS, INC. · 2020 · $299,268 — ABSTRACT We propose to develop a point-of-need system for differential molecular identification of filoviruses from syndromically similar infections. Our goal is to enable rapid, sensitive, and specific identification of quarantinable infections to reduce nosocomial risk and improve outbreak respons…