Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Sheng Luan · UNIVERSITY OF CALIFORNIA BERKELEY · 2022 · $66,680 — This equipment supplement application seeks funding for replacement of a broken growth chamber for culturing plant materials used in the parent project. The model plant Arabidopsis must be grown and maintained in a controlled environments. In particular, our plants are routinely transgenic containin…
JANE B TREPEL · DIVISION OF CLINICAL SCIENCES - NCI · 2022 · $1,205,526 — Our major activities in FY2022 were to work with clinical investigators to develop new pharmacodynamic (PD) assays tailored to their clinical trials and to implement these PD assays in the clinical trials we have open in FY2022. Our specific objectives are (1) to determine if a therap…
David Aaron Jacobson · VANDERBILT UNIVERSITY · 2022 · $449,622 — Project Summary Islet glucose-stimulated somatostatin (Sst) secretion is lost in patients with type-2 diabetes (T2D) and in animal models of the disease, which contributes to disrupted glucagon and insulin secretion. It is generally accepted that Sst secretion from -cells occurs in response to elev…
KENNETH R COOKE · JOHNS HOPKINS UNIVERSITY · 2022 · $400,716 — Allogeneic blood and marrow transplantation (allo-BMT) is the only curative therapy for many pediatric patients with malignant and non-malignant disorders. Unfortunately, treatment-related complications remain a major barrier to successful outcomes. A multiple organ dysfunction syndrome (MODS) works…
Ashley Loeven · FLORIDA STATE UNIVERSITY · 2022 · $41,151 — ABSTRACT Previous experiments in our lab have shown that a fatty diet reduces olfactory sensory neuronal abundance. Isocaloric feeding in which a fat-fed mouse consumed the same number of calories as a control-fed mouse, but of fatty chow, prevented obesity but did not prevent the neuronal loss. It …
ROBERT KREITMAN · DIVISION OF BASIC SCIENCES - NCI · 2022 · $1,340,622 — Overview. We focus on targeted therapy for hematologic malignancies, particularly hairy cell leukemia (HCL), and other new therapies for HCL. Moxetumomab pasudotox (Moxe) contains truncated Pseudomonas exotoxin (PE) fused to an anti-CD22 Fv fragment. Previously called HA22 or CAT-8015…
Donald M Bers · UNIVERSITY OF CALIFORNIA AT DAVIS · 2021 · $760,168 — Project Summary Our overall goal is to understand the structural mechanisms for the functional dysregulation of the cardiac ryanodine receptor (RyR2) Ca2+-release channels in the sarcoplasmic reticulum (SR). RyR2 contributes to and is a therapeutic target for treating heart failure (HF) and arrhythm…
JANE B TREPEL · DIVISION OF CLINICAL SCIENCES - NCI · 2021 · $1,199,893 — Our major activities in FY2021 were to work with clinical investigators to develop new pharmacodynamic (PD) assays tailored to their clinical trials and to implement these PD assays in the clinical trials we have open in FY2021. Our specific objectives are (1) to determine if a therapy hit its targe…
Daniel Reich · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2021 · $5,061,016 — In Fiscal Year 2021, we have continued to pursue two specific aims: (1) to study the pathophysiology of MS through high-resolution MRI and (2) to study the biology of inflammatory demyelination in a translationally relevant primate model of MS. We have seen significant progress toward accomplishing …
KENNETH R COOKE · JOHNS HOPKINS UNIVERSITY · 2021 · $400,716 — Allogeneic blood and marrow transplantation (allo-BMT) is the only curative therapy for many pediatric patients with malignant and non-malignant disorders. Unfortunately, treatment-related complications remain a major barrier to successful outcomes. A multiple organ dysfunction syndrome (MODS) works…
CRAIG S LEVIN · STANFORD UNIVERSITY · 2021 · $157,700 — Project Summary / Abstract (from parent application) We propose to create and explore a radio-frequency (RF)-penetrable positron emission tomography (PET) system technology that can be inserted into a magnetic resonance imaging (MRI) system for acquiring simultaneous PET/MRI data. Integrated PET/MRI…
JANE B TREPEL · DIVISION OF CLINICAL SCIENCES - NCI · 2020 · $1,097,545 — Our major activities in FY2020 were to work with clinical investigators to develop new pharmacodynamic (PD) assays tailored to their clinical trials and to implement these PD assays in the clinical trials we have open in FY2020. Our specific objectives are (1) to determine if a therapy hit its targe…
KENNETH R COOKE · JOHNS HOPKINS UNIVERSITY · 2020 · $408,895 — Allogeneic blood and marrow transplantation (allo-BMT) is the only curative therapy for many pediatric patients with malignant and non-malignant disorders. Unfortunately, treatment-related complications remain a major barrier to successful outcomes. A multiple organ dysfunction syndrome (MODS) works…
Donald M Bers · UNIVERSITY OF CALIFORNIA AT DAVIS · 2020 · $760,168 — Project Summary Our overall goal is to understand the structural mechanisms for the functional dysregulation of the cardiac ryanodine receptor (RyR2) Ca2+-release channels in the sarcoplasmic reticulum (SR). RyR2 contributes to and is a therapeutic target for treating heart failure (HF) and arrhythm…
ZAYD M KHALIQ · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2019 · $1,793,169 — Our laboratory studies the cellular and subcellular principles of integration and excitability in dopamine-releasing neurons located in the midbrain. A major interest of the lab is identifying functionally unique subpopulations of midbrain dopamine neurons and understanding how these neurons contrib…
Donald M Bers · UNIVERSITY OF CALIFORNIA AT DAVIS · 2019 · $774,418 — Project Summary Our overall goal is to understand the structural mechanisms for the functional dysregulation of the cardiac ryanodine receptor (RyR2) Ca2+-release channels in the sarcoplasmic reticulum (SR). RyR2 contributes to and is a therapeutic target for treating heart failure (HF) and arrhythm…
Bjorn C Knollmann · VANDERBILT UNIVERSITY MEDICAL CENTER · 2019 · $552,322 — DESCRIPTION (provided by applicant): Although atrial fibrillation (AF) is the most prevalent cardiac arrhythmia requiring antiarrhythmic drug therapy, response in an individual patient is highly variable with frequent AF recurrence. The limited success of drug therapy has been attributed in part to …
Ankit Bharat · NORTHWESTERN UNIVERSITY AT CHICAGO · 2019 · $162,086 — DESCRIPTION (provided by applicant): Candidate: Dr. Bharat's academic training, research experience and drive place him in an excellent position for a successful career to become a leading independent investigator. He intends to pursue a career in academic surgery with a strong commitment to b…
Cara Brook · UNIVERSITY OF CHICAGO · 2024 · $91,090 — The wide-reaching impacts of the COVID-19 pandemic highlight the extreme threat posed by the cross-species emergence of zoonotic pathogens. Bats (order: Chiroptera) are the natural reservoir hosts for the majority of the world’s most virulent zoonotic viruses, including Hendra and Nipah henipaviruse…
Olivia Cords · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $41,972 — ABSTRACT Coronavirus Infection Dynamics and Cross-species Transmission in Bats Prevention of future zoonotic disease emergence, including pandemic threats, is only possible with a thorough understanding of infection dynamics in reservoir host populations. The emergence of SARS-CoV, MERS, and SARS-Co…