Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Scott C Weaver · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $1,545,268 — Arthropod-borne viruses (arboviruses) such as chikungunya (CHIKV) and Zika (ZIKV), as well as rodent- and bat-borne viruses such as Lassa fever and probably Ebola, are among the most important causes of emerging infectious diseases, and many circulate enzootically in W. Africa. The mechanisms whereb…
Alexander Niclas Freiberg · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $240,000 — ABSTRACT Nipah and Hendra viruses are recently emerged bat-borne paramyxoviruses (genus Henipavirus) causing severe encephalitis and respiratory disease in humans with fatality rates ranging from 40-75%. Despite the severe pathogenicity of these viruses and their pandemic potential, no therapeutics …
Susan R Weiss · UNIVERSITY OF PENNSYLVANIA · 2021 · $447,637 — Middle East respiratory syndrome virus (MERS), a zoonotic lineage C Betacoronavirus discovered in 2012, has caused over 2,000 infections and more than 700 deaths. The emergence of MERS in addition to SARS highlights the public health significance of virulent, emerging coronaviruses (CoVs). MERS is d…
Christopher F Basler · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $186,654 — The Middle East respiratory syndrome coronavirus (MERS-CoV), is a highly pathogenic, zoonotic, non-segmented, positive-sense RNA virus related to the severe acute respiratory syndrome coronavirus (SARS CoV) and SARS-CoV-2 that can spread from person to person. The potential threat posed by zoonotic …
Philippe DUSSART · PASTEUR INSTITUTE FROM MADAGASCAR · 2020 · $134,977 — Zoonotic pathogens derived from an animal reservoir account for some 60-75% of emerging infectious diseases in humans, a disproportionate number of which take place in resource poor countries where the economic and social burden of corresponding health crises is greatest. Bats have received much att…
Scott C Weaver · UNIVERSITY OF TEXAS MED BR GALVESTON · 2020 · $1,702,711 — Arthropod-borne viruses (arboviruses) such as chikungunya (CHIKV) and Zika (ZIKV), as well as rodent- and bat-borne viruses such as Lassa fever and probably Ebola, are among the most important causes of emerging infectious diseases, and many circulate enzootically in W. Africa. The mechanisms whereb…
Ralph S Baric · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $658,139 — Abstract Zoonotic coronaviruses (CoV) are responsible for three major epidemics/pandemics in the 21st century, including Severe Acute Respiratory Coronavirus (SARS-CoV) in 2003 and the Middle East Respiratory coronavirus (MERS-CoV) in 2012. In Dec 2019, a third novel CoV designated SARS-CoV-2 emerge…
Diane Bimczok · MONTANA STATE UNIVERSITY - BOZEMAN · 2020 · $493,788 — Summary The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious human respiratory tract pathogen that has the capacity to infect many different organ systems, including the gastrointestinal (GI) tract. The overall goal of this project is to elucidate the rol…
Susan R Weiss · UNIVERSITY OF PENNSYLVANIA · 2020 · $283,269 — Middle East respiratory syndrome virus (MERS), a zoonotic lineage C Betacoronavirus discovered in 2012, has caused over 2,000 infections and more than 700 deaths. The emergence of MERS in addition to SARS highlights the public health significance of virulent, emerging coronaviruses (CoVs). MERS is d…
Susan R Weiss · UNIVERSITY OF PENNSYLVANIA · 2020 · $447,595 — Middle East respiratory syndrome virus (MERS), a zoonotic lineage C Betacoronavirus discovered in 2012, has caused over 2,000 infections and more than 700 deaths. The emergence of MERS in addition to SARS highlights the public health significance of virulent, emerging coronaviruses (CoVs). MERS is d…
Susan R Weiss · UNIVERSITY OF PENNSYLVANIA · 2019 · $447,387 — Middle East respiratory syndrome virus (MERS), a zoonotic lineage C Betacoronavirus discovered in 2012, has caused over 2,000 infections and more than 700 deaths. The emergence of MERS in addition to SARS highlights the public health significance of virulent, emerging coronaviruses (CoVs). MERS is d…
Susan C. Baker · LOYOLA UNIVERSITY CHICAGO · 2019 · $705,182 — DESCRIPTION (provided by applicant): The goal of our research is to determine how viral proteases function in the replication and pathogenesis of coronaviruses (CoVs). CoVs are a family of positive strand RNA viruses and include Severe Acute Respiratory Syndrome (SARS) CoV and Middle East Respi…
Jean-Michel HERAUD · PASTEUR INSTITUTE FROM MADAGASCAR · 2019 · $134,653 — Zoonotic pathogens derived from an animal reservoir account for some 60-75% of emerging infectious diseases in humans, a disproportionate number of which take place in resource poor countries where the economic and social burden of corresponding health crises is greatest. Bats have received much att…
Nicolae Valentin David · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $656,337 — PROJECT SUMMARY Intact fibroblast growth factor 23 (iFGF23) is a phosphate regulating hormone secreted by bone. In chronic kidney disease (CKD), increased Fgf23 transcription is associated with cardiovascular mortality, disturbed iron metabolism and anemia. Fgf23 transcription is physiologically cou…
Kyle Stearns · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $48,974 — Project Summary Human parainfluenza viruses (HPIV) cause significant lower respiratory diseases, including croup, bronchiolitis, and pneumonia, that lead to illness or death in millions of infants and young children worldwide. Viral infection is initiated when the viral fusion complex, comprised of …
Stephen Leppla · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $933,913 — There is increasing recognition in the research and development community that the anthrax toxin proteins constitute a uniquely effective tool for delivering materials to the cytosol and nucleus of eukaryotic cells. Our own work with a non-toxic fusion of the N-terminal portion of lethal factor (LF…
Richard Thomas Wyatt · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $739,446 — Abstract Structure-based vaccine design holds great promise for combatting viral pathogens that create substantial burdens on global health. For HIV, the soluble ectodomain of the envelope glycoprotein (Env), which is the primary target for neutralizing antibody responses, is the focal point for …
Richard Thomas Wyatt · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $928,096 — Abstract Structure-based vaccine design holds great promise for combatting viral pathogens that create substantial burdens on global health. For HIV, the soluble ectodomain of the envelope glycoprotein (Env), which is the primary target for neutralizing antibody responses, is the focal point for …
Soon Seog Jeong · HUMAN CELL CO · 2024 · $365,000 — Project Summary Dry eye disease (DED) is an increasingly frequency cause of visual dysfunction. It is characterized by loss of homoeostasis of the ocular surface, resulting in tear film instability, hyperosmolarity, and inflammation of the conjunctiva and cornea. Up to 30% of the population over ag…
Nathalie Pamir · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $510,062 — Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a low-abundance plasma protein that reduces the expression of the LDL receptor (LDLR) and therefore plays a critical role in cholesterol trafficking. Its discovery revolutionized our understanding of cholesterol metabolism, shifting the homeos…