Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Alexander H Flannery · UNIVERSITY OF KENTUCKY · 2024 · $99,759 — PROJECT SUMMARY/ABSTRACT This proposal includes a five-year research career development program to study classical and alternative renin-angiotensin system (RAS) dysregulation in sepsis-associated acute kidney injury (SA-AKI). The candidate is currently an Assistant Professor at the University of Ke…
Ivan Marazzi · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $747,848 — PROJECT SUMMARY Infection causes inflammation, which contributes to pathogen clearance and survival of the host organism. However, failure to regulate the inflammatory response can often lead to multiple organ damage and lethality for the host. In the current COVID-19 pandemic caused by the severe a…
Eric D Lazartigues · LSU HEALTH SCIENCES CENTER · 2024 · $538,276 — With prevalence as high as 55% for individuals aged 55 and older in United States, hypertension (HTN) is a major risk factor contributing to cardiovascular diseases (CVD) and global mortality, hence remaining an increasingly important medical and public health issue. The role of the brain renin-angi…
Monica Kraft · UNIVERSITY OF ARIZONA · 2024 · $1,431,641 — In this AADCRC program renewal, we will focus on three critical and understudied innate immune factors and how they impact viral infections in asthma: the anionic phospholipids of surfactant (palmitoyl- oleoyl-phosphatidylglycerol, POPG, and phosphatidylinositol, PI), Toll interacting protein (Tolli…
ANTHONY W ORVEDAHL · WASHINGTON UNIVERSITY · 2024 · $933,000 — PROJECT SUMMARY/ABSTRACT The host inflammatory response is a double-edged sword that must vigorously defend against pathogens, but also requires restraint to prevent unintended injury to the host. The Cytokine Storm Syndrome (CSS) represents a state of unbridled inflammation that can be triggered b…
Andrea Lee Frump · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $768,905 — PROJECT SUMMARY This proposal builds on the scientific premise that right ventricular (RV) maladaptive remodeling is a major contributor to RV failure and mortality in pulmonary hypertension (PH). Despite its importance, no RV-directed therapies exist. The goal of this proposal is to is to identify …
Matthew J. Flick · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $531,940 — SUMMARY Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2; CoV2) is the first highly pathogenic and highly transmissible human coronavirus that is the causative agent for the worldwide COVID-19 pandemic. As of November 2020, 50 million cases of CoV2 infection worldwide and 1.25 million dea…
GR Scott Budinger · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $725,783 — PROJECT SUMMARY This application directly stems from our recent publication in Nature in which we analyzed bronchoalveolar lavage (BAL) fluid from 88 patients with critical SARS-CoV-2 pneumonia using a combination of flow cytometry, bulk transcriptomic profiling of flow sorted alveolar macrophages a…
KENNETH E BERNSTEIN · CEDARS-SINAI MEDICAL CENTER · 2024 · $560,426 — A long sought goal of medical research is to identify ways to increase the effectiveness of the immune response. Here, we present a means of increasing myeloid cell function by increasing cell expression of angiotensin converting enzyme (ACE). We show that 1) under natural circumstances in both huma…
ALEXEY VLAD ONUFRIEV · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2024 · $297,987 — Project Summary. This proposal responds to PAR-19-253 “Focused Technology Research and Development”. Our main goal is to develop a novel class of implicit solvation models, as accurate, and even more accurate, than standard explicit solvent models, but much faster. The high accuracy, fast implicit s…
Stijn Piet Johan De Langhe · MAYO CLINIC ROCHESTER · 2024 · $934,920 — Idiopathic pulmonary fibrosis (IPF) is a common form of interstitial lung disease (ILD), resulting in alveolar remodeling and progressive loss of pulmonary function, respiratory failure, and death often within 5 years of diagnosis. Genetic and experimental evidence support the concept that chronic a…
Andrei A Vakhtin · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · 2024 · $709,373 — ABSTRACT: Approximately one third of non-hospitalized coronavirus disease of 2019 (COVID-19) patients report chronic symptoms after recovering from the acute stage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Some of the most persistent and common complaints of this pos…
Lisa Anne Vrooman · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $493,409 — PROJECT SUMMARY There is evidence from human and animal studies that support that imbalance in the renin-angiotensin system (RAS), specifically reduced ACE2 protein levels and/or activity, leads to adverse maternal and fetal outcomes. Mouse dams and concepti with loss-of-function alleles of ACE2 exh…
Chien-Ting Wu · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $499,989 — Project Summary Human respiratory tissues have a unique cellular architecture and a mucus-based clearance system that, together, constitute an impressive barrier to viruses that use the airway epithelium as their portal of entry. The mucus-based clearance system acts as a physical, innate defense me…
Shelli Farhadian · YALE UNIVERSITY · 2024 · $417,822 — Project Summary The COVID-19 pandemic has rampantly affected the population of the world and created lasting effects on the economy, health and psyche of the global community. Although it shares similarities with SARS-CoV-1, the full extent of the pathophysiology caused by SARS-CoV-2 is unclear. In …
Todd B Reynolds · UNIVERSITY OF TENNESSEE KNOXVILLE · 2024 · $518,119 — Candida albicans and related Candida spp. are responsible for ~400,000 invasive infections/year, which have an ~50% mortality rate. A crucial virulence trait of C. albicans, and other fungi, is the ability to diminish their detection by their hosts. The cell wall carbohydrate ß(1,3)-glucan is an imp…
Ralph S Baric · WASHINGTON UNIVERSITY · 2024 · $1,193,360 — Project Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that was first isolated in Wuhan China in December, 2019. SARS-CoV-2 is the cause of coronavirus disease 2019 (COVID-19), which is now a pandemic and has caused more than 1.3 mi…
Megan A O'Connor · UNIVERSITY OF WASHINGTON · 2024 · $785,351 — PROJECT SUMMARY/ABSTRACT COVID-19 vaccination reduces the risk of SARS-CoV-2 infection and severe disease, but almost half of hospitalized breakthrough cases are in immunocompromised individuals. HIV infection is an independent risk factor for severe COVID-19, hospitalization, and mortality. Immunoc…
Han Peng · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $481,939 — PROJECT SUMMARY/ABSTRACT The long-term goal of this project is to understand the functions of selective autophagy in corneal inflammation as well as corneal/limbal epithelial differentiation. Selective autophagy is a specialized form of autophagy and can control signaling pathways in cells by specif…
Daniel Barber · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $397,520 — SARS-CoV-2 infection has a spectrum of clinical disease outcomes, ranging from asymptomatic to fatal. The severity of COVID-19 is largely determined by the degree of virus-induced damage and immune-mediated pathology. However, the factors that prevent or promote pulmonary inflammation during SARS-Co…