Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Kenneth L Shepard · QUICKSILVER BIOSCIENCES, INC. · 2022 · $447,801 — Direct bioelectronic detection of SARS-CoV-2 from saliva using single-molecule field-effect transistor array Nucleic acid tests have become the gold-standard for diagnostic testing for COVID-19, usually performed in specialized laboratories. Most are based on reverse-transcription quantitative pol…
Samuel Matthew Young · UNIVERSITY OF IOWA · 2022 · $385,434 — The diversity of information encoding by neuronal circuits is regulated by the magnitude and location of Ca2+ entry though voltage-gated Ca2+ channels (CaV). In the mammalian central nervous system, the CaV2.1 channel is the critical subtype for CNS function since it is the most efficient CaV2 subty…
Radislav A Potyrailo · GENERAL ELECTRIC GLOBAL RESEARCH CTR · 2022 · $599,859 — PROJECT SUMMARY/ABSTRACT Available tools for detection of SARS-CoV-2 virus require extensive sample preparation and/or expensive lab- based equipment to obtain accurate results. The objective in this proposal is to build a touch-screen sensor array to directly capture, detect, and identify model SAR…
YAN XIANG · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2022 · $232,500 — Summary The novel coronavirus SARS-CoV-2 causes the COVID-19 pandemic. The virus infects through the respiratory tracts. While most COVID-19 patients display no or mild clinical symptoms, a small percentage develop severe immune-mediated pathological complications, which could lead to injury and fai…
Aleksandra Elzbieta Sikora · OREGON STATE UNIVERSITY · 2022 · $703,672 — ABSTRACT Neisseria gonorrhoeae (Ng), the gram-negative bacterium responsible for the sexually transmitted infection gonorrhea, is categorized as a high-priority pathogen for research and development efforts. In the US, over 50% of Ng isolates are resistant to at least one antimicrobial and the CDC h…
Anne Moscona · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2022 · $722,958 — No vaccines or treatments for SARS-CoV-2 are yet available. A simple prophylactic antiviral strategy would protect naïve individuals from infection now. In the future, when vaccines should be available, a prophylactic antiviral will be essential for individuals who do not mount a suitable immune res…
Deyu Fang · NORTHWESTERN UNIVERSITY AT CHICAGO · 2022 · $779,400 — Abstract Biomarker-guided treatment is key to improve outcomes of many diseases. The current COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis due to lagged vaccination and inefficient control of the virus, which has caused over 253 million c…
Elke BergmannLeitner · THOMAS JEFFERSON UNIVERSITY · 2022 · $225,781 — PROJECT SUMMARY As COVID-19 pandemic continues with the evolution of new strains, we acknowledge the groundwork that has been done evaluating maternal immunity following COVID-19 vaccine or disease exposure in pregnancy, and passive transmission of antibodies in cord blood and breastmilk. There rema…
Priyamvada Acharya · DUKE UNIVERSITY · 2022 · $695,359 — Structural characterization of Fab-dimerized glycan-reactive antibodies that neutralize HIV-1 A glycan shield covers the HIV-1 envelope (Env) limiting antibody access to broadly neutralizing antibody (bnAb) epitopes. 2G12 had for long been the only example of a HIV-1 bnAb that interacts solely with…
VINEET D MENACHERY · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $497,886 — Abstract The coronavirus (CoV) spike protein is a key viral determinant responsible for receptor binding and fusion/entry. The spike protein has also been predicted to be the major factor driving cross-species transmission, allowing the emergence of epidemic strains like SARS- and MERS-CoV. In the f…
Alex Joseph Guseman · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 · $100,000 — Project Summary/Abstract In late 2019, the SARS-CoV2 virus emerged as a global pandemic, causing the severe respiratory disease COVID-19 and resulting in millions of deaths worldwide. As a coronavirus, SARS-CoV2 host interactions are dictated through the Spike proteins that encompass the virion. The…
Kartik Balachandran · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · 2022 · $436,642 — PROJECT SUMMARY Recent reports have uncovered the role of angiotensin-converting enzyme 2 (ACE2) as the receptor for mediating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into host cells. The aortic valve is one specific tissue within the cardiovascular system that has robust …
YUPING WANG · LOUISIANA STATE UNIV HSC SHREVEPORT · 2022 · $182,500 — COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as the greatest threat to global health and significantly impact pregnant women worldwide. COVID-19 infection during pregnancy is associated with substantial risk of increases in maternal morbidity and mort…
Lanying Du · GEORGIA STATE UNIVERSITY · 2022 · $759,731 — Summary A novel coronavirus (CoV), SARS-CoV-2, is causing global pandemics with growing numbers of daily cases and deaths. SARS-CoV-2 is closely related to SARS-CoV, which caused the 2002-2003 SARS epidemic, and less closely related to MERS-CoV, which causes a high mortality rate in infected patient…
MICHAEL DAVID ALPERT · EMMUNE, INC · 2022 · $300,000 — ABSTRACT We are developing vaccine antigens for SARS-CoV-2 that focus the antibody response onto neutralizing epitopes in the receptor binding domain (RBD) of the viral Spike (S) protein. Efficient expression of the RBD in technically-demanding formats, e.g., on a self-assembling multimer scaffold,…
VAHRAM HAROUTUNIAN · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2022 · $1,267,500 — PROJECT SUMMARY Alzheimer’s disease (AD) stands out as notable in two respects––in not having a cure and in affecting women more than men. While declining estrogen has been thought to underpin post–menopausal AD, there is a clear clinical correlation of AD with rising levels of follicle–stimulating…
Alvin Yu · UNIVERSITY OF CHICAGO · 2022 · $90,000 — PROJECT SUMMARY Viruses are infectious agents that replicate inside the living cells of an organism, and it remains critical to understand the basic molecular mechanisms that govern viral replication, as they perform numerous complex physical and chemical processes ranging from atomic-scale phenomen…
David Huw Davies · UNIVERSITY OF CALIFORNIA-IRVINE · 2022 · $575,733 — PROJECT SUMMARY/ABSTRACT In this proposal we will define molecular and cellular mechanisms of different combinations of known adjuvant components MPLA (a TL4 agonist), CpG (a TLR9 agonist), agonists of cGAS-STING and NOD1/2 pathways, and a squalene-in-water emulsion (AddaVAX™). Our overall Aim is to…
Bryce C Chackerian · MASSACHUSETTS GENERAL HOSPITAL · 2022 · $546,158 — Project Summary / Abstract This proposal describes the framework of an R01 grant by Dr. Daniel Lingwood, an Assistant Professor at Harvard Medical School and faculty member of the Ragon Institute of MGH, MIT and Harvard, and Dr. Bryce Chackerian, an Associate Professor in the Department of Molecular…
Priyamvada Acharya · DUKE UNIVERSITY · 2022 · $762,466 — Effect of natural and engineered variations on structure and biophysics of SARS-CoV-2 spike COVID-19, caused by SARS-CoV-2, has devasted global health and economics. Vaccines are being deployed worldwide to gain control of the pandemic, although emergence of fast-spreading “variants of concern” (VO…