Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Farhang Alem · GEORGE MASON UNIVERSITY · 2022 · $4,039,853 — Project Summary/Abstract: The ongoing COVID pandemic has demonstrated the need for state-of-the-art facilities and infrastructure to improve our preparedness for subsequent epidemics and/or pandemics. George Mason University (GMU), leveraging the Regional Biocontainment Laboratory, designated as the…
Anilkumar Pillai · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2022 · $445,694 — Chronic stress is a risk factor for the development of multiple psychiatric disorders for which current treatments are inadequate. Evidence from our laboratory and others suggest that chronic stress can also provoke elevated inflammation and exaggerated inflammatory responses in both humans and anim…
Rebecca Bradford · AMERICAN TYPE CULTURE COLLECTION · 2022 · $3,862,721 — Project Summary: The proposed project aims to renovate ATCC's High Containment Facility (HCF) at the American Type Culture Collection (ATCC) in Manassas, Virginia. ATCC's 7,500 ft2 biocontainment facility was built in 2007 with funding from NIAID and has been dedicated to developing infectious disea…
sandra Paige story · NUBAD, LLC · 2022 · $299,900 — PROJECT SUMMARY The world is immersed in a health crisis rivaled only by the Spanish flu pandemic of 1918-1919. The difference between the crisis of today and the crisis a century ago is that we have advanced communication technology greatly so that huge populations of people around the globe are aw…
Margaret Juliana McElrath · FRED HUTCHINSON CANCER CENTER · 2022 · $929,677 — Abstract: With the rapid onset of the COVID-19 pandemic, we recognize there is a significant gap in knowledge in the field on the contribution of immune functions involved in preventing infection, in modifying COVID-19 disease, and in clearing viral infection. We believe the HVTN is well placed to s…
Sally Lynn Hodder · WEST VIRGINIA UNIVERSITY · 2022 · $645,360 — Electronic Health Record (EHR) data collected during routine clinical care offer real world evidence to support decision making and observational research. The National COVID Cohort Collaborative (N3C) is a centralized national EHR data resource for the study of COVID-19 patient outcomes. Centers su…
DEAN R MADDEN · DARTMOUTH COLLEGE · 2022 · $2,460,000 — The Dartmouth Institute for Biomolecular Targeting (bioMT) infuses mechanistic investigations with a sophisticated awareness of disease pathology and therapeutic need, enhancing the quality of even the most fundamental research. At the same time, it helps orient mechanistic investigations towards lo…
Dennis A Bente · THOMAS JEFFERSON UNIVERSITY · 2022 · $779,687 — Crimean-Congo hemorrhagic fever virus (CCHFV) causes severe disease in humans, with fatality rates reaching 40%. CCHFV is endemic to parts of Africa, Asia, the Middle East, and Europe, specifically to regions where the tick vector, species of the Hyalomma genus, is present. Classified as an NIH/NIAI…
Patricia L Hibberd · BOSTON UNIVERSITY MEDICAL CAMPUS · 2022 · $568,497 — Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS- CoV-2) was first reported in Wuhan, Hubei Province of China in December 2019 and by early 2021, there have been more than 100 million cases of COVID-19 globally. The consequences of COVID-19 in preg…
Jonathan B Overdevest · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2022 · $178,610 — PROJECT SUMMARY Smell loss is a common neurosensory disability accompanying infection with SARS-CoV-2 novel coronavirus. The frequency and persistence of alteration in the ability to smell, or olfactory dysfunction (OD), observed during the COVID-19 pandemic highlight a knowledge gap, where risk fac…
Margaret Leighton McNairy · WEILL MEDICAL COLL OF CORNELL UNIV · 2022 · $124,224 — ABSTRACT: The goals of this K24 proposal are to train clinical investigators in the conduct of patient-oriented cardiovascular disease (CVD) research primarily in Haiti, with a new project in Tanzania and to conduct a new study on environmental lead exposure and CVD risk factors in Haiti (Aim 1). Th…
Benjamin F Arnold · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $723,537 — Enteric pathogen infections are a leading cause of the global disease burden, with the largest burden among children in low-resource settings. Stool-based PCR methods have dramatically improved our ability to measure enteric infections, but the challenge of collecting stool and need for near-continu…
JOHN BILLIMEK · UNIVERSITY OF CALIFORNIA-IRVINE · 2022 · $595,273 — Project Abstract Community health workers (CHWs) played an essential role in addressing multi-level, community barriers to accessing COVID-19 information, testing, risk mitigation, and vaccination; however, little is known about how CHWs managed their roles in light of enormous social, community, an…
Michelle Weiss Katzow · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · 2022 · $190,836 — PROJECT SUMMARY/ABSTRACT This Mentored Patient-Oriented Research Career Development Award (K23) proposal will address an urgent need to advance the science of child obesity prevention in low-income, minority communities, a priority of the National Heart, Lung, and Blood Institute. Simultaneously, it…
STEVEN A BENNER · FOUNDATION FOR APPLIED MOLECULAR EVOLUTN · 2022 · $741,716 — Basic Research to Diagnostics and Surveillance in Lower Resource Environments Foundation for Applied Molecular Evolution Steven A. Benner ABSTRACT We will deliver to the NIAID and CDC communities, through basic research, a scientific understanding of pairing, mispairing, and enzymology of natural …
Kelly Doran · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2022 · $802,854 — PROJECT SUMMARY Over 1.4 million people experience homelessness in the U.S. each year. A large body of evidence has demonstrated the bidirectional relationship between homelessness and substance use (SU), and overdose is the leading cause of death among people experiencing homelessness. The COVID-19…
Peter Daszak · ECOHEALTH ALLIANCE, INC. · 2022 · $653,392 — 1 Two major coronaviral diseases of wildlife origin have emerged in Asia in the last two decades. Both likely 2 began as zoonotic spillover events, leading to small case clusters, but were not identified until significant 3 community spread made control difficult, and in the case of COVID-19, led …
Minolfa C Prieto · GORDON RESEARCH CONFERENCES · 2022 · $40,000 — PROJECT SUMMARY The renin angiotensin aldosterone system (RAAS) is a key regulator of cardiovascular (CV) function, fluid electrolyte balance, and homeostasis, and it influences many systems including the renal, neuroendocrine, and immune systems. Perturbations of the RAAS trigger a cascade of event…
Gary Fujii · MOLECULAR EXPRESS, INC. · 2022 · $298,479 — Project Summary The principal goal of this project is to demonstrate that the FDA-approved anthelminthic drug, niclosamide, can be reformulated in a synthetic lung surfactant which can be aerosolized for the treatment of infections caused by respiratory viruses. The studies proposed in this SBIR Ph…
David M Koelle · UNIVERSITY OF WASHINGTON · 2022 · $220,624 — Summary The acquired, antigen-specific immune response to SARS-CoV-2-infection is likely central to determining the outcome of COVID-19 and the efficacy and durability of vaccination. CD4 T cell help is required for lasting, avid antibody responses. The leading vaccine candidates include some format…