NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Jonathan L Zelner · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $679,307 — Project Summary/Abstract The distribution of disease and death from the COVID-19 pandemic has been grossly unequal in every dimension. The vaccination campaign, throughout Winter and Spring 2021, has seen these inequities repeated. Lower-risk, wealthier, and Whiter individuals have received earlier …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Ruili Huang · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2022 · $502,225 — The Tox21 Programs federal partners include the Environmental Protection Agency (EPA), the Food and Drug Administration (FDA) and NIH, with leadership from NCATS and the National Toxicology Program (NTP) at the National Institute of Environmental Health Sciences (NIEHS). These agencies work together…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Janet Hall · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2022 · $685,603 — The Environmental Polymorphisms Registry (EPR), now called Personalized Environment and Genes Study (PEGS) of over 17,000 participants provides a unique resource for a variety of studies dedicated to clarifying the interaction of genetic and environmental determinants of human health. The PEGS's sub…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
ALEXANDER PLETNEV · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $675,862 — The pathogenesis of flaviviral neuroinfection is complex and depends on a series of events involving (1) virus replication in the periphery to produce and sustain the level of viremia sufficient for neuroinvasion, (2) virus entry into the CNS (neuroinvasiveness), (3) virus replication, spread, and i…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Marc Ferrer · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2022 · $90,219 — We have established protocols for culturing primary human small airway epithelial cells and alveolar cells in a transwell air-liquid-interface (ALI) model. Tissue biofabrication has been optimized in a 96-well plate format, including the formation of a microvessel network. We are positioning these…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Richard Davey · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $3,483,874 — Novel means first to better characterize and then to treat infection with major respiratory pathogens using existing or newly developed strategies are a primary focus of this important project within the Clinical Research Section. In this regard, our Section has undertaken clinical research efforts …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
William Elkins · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $28,533 — COVID 19 related projects: Humanized animals: Using CRISPR/cas9 mediated gene KI via specific gRNAs and ODNTs, several lines have been created with the human ACE2 mutations individually in exons #2, exon #3 and exon #9. In the second stage, the sperm from these lines was used to create embryos tha…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Iyadh Douagi · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $495,304 — The project particularly aims to use state of the art instrumentation to support the immediate research needs for COVID19 research in flow cytometry. We are interested in developing new capacities for high-dimensional cell sorting requiring the precise identification of rare cell subsets based on m…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Keir Neuman · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2022 · $1,567,748 — Research in Progress The first project is focused on elucidating mechanistic details of the interaction between type II topoisomerases and DNA. One aspect of this interaction concerns the ability of type II topos to relax the topology of DNA to below equilibrium values. In vivo, these topoisomerases…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Xiaoling Li · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2022 · $3,474,264 — In the past year, our efforts focus on the role of SIRT1 and/or protein acylation in regulation of embryonic stem cell metabolism, differentiation, and animal development, and the impact of intestinal epithelial glucocorticoid signaling on intestinal inflammation, anti-tumor immunity, and tumorigene…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Scott Auerbach · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2022 · $4,764,641 — Core Key Area 1. Our work provides researchers with computational resources needed for analytical work and tool development. 2. Delivered goals included: a. Deployment of RStudio Connect to support deployment of visual-analytics tools. b. Support for data processing pipelines using Knime softw…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
NICO TJANDRA · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2022 · $1,309,932 — As a progression in developing new technology to characterize dynamic molecular events which regulate important biological function, we chose to look at retroviral capsid assembly. This protein is a part of the Gag-poly protein which is processed as part of the maturation of the virus. The assembly …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
MARC NICKLAUS · DIVISION OF BASIC SCIENCES - NCI · 2022 · $180,592 — In collaboration with several Principal Investigators at the CCR/NCI, in silico screening of large small-molecule databases are being conducted for a number of molecular targets relevant for cancer. We are using the CADD Group's resources, including our screening databases to generate…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Hongtao Yu · MORGAN STATE UNIVERSITY · 2022 · $271,599 — PROJECT SUMMARY The goal of this HIV/HCV/COVID-19 supplement project is to expand the original study cohort for studying (1) the feasibility of and barriers to achieving HCV elimination among people living with HIV (PLWH) and people at risk of HIV (PARH) through linkage to HIV care and prevention an…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
David S Perlin · HACKENSACK UNIVERSITY MEDICAL CENTER · 2022 · $7,558,755 — The MAVDA Administrative Core (MAC) will be established as an integrated, priority-setting consortium involving the Program Directors (PDs), a Business Director (BD), an internal MAVDA Leadership Team (MLT), and a Scientific Advisory Board (SAB) with programmatic involvement from NIAID to enhance po…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Lucio Miele · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2022 · $276,877 — Project Summary: Biomedical Informatics Core The overall goal of the Biomedical Informatics (BMI) Core of the Louisiana Clinical and Translational Science Center (LA CaTS) is to build on our accomplishments and continue to develop and deploy “state of the art” informatics services to LA CaTS inve…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Diana Montserrat Sheehan · FLORIDA INTERNATIONAL UNIVERSITY · 2022 · $354,222 — FIU-RCMI Research Project #3 Abstract The twin pandemics of human immunodeficiency virus (HIV) and COVID-19 share uncanny similarities with respect to racial/ethnic and socioeconomic disparities in both incidence and mortality. Structural strategies for HIV and COVID-19 outcomes could augment curren…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Alan Tackett · ARKANSAS CHILDREN'S HOSPITAL RES INST · 2022 · $770,000 — PROJECT SUMMARY The Administrative Core will provide operational oversight for the Center for Translational Pediatric Research (CTPR) at the Arkansas Children’s Research Institute (ACRI) during COBRE Phase II. The Center Director, Dr. Alan Tackett, will lead the Administrative Core both in the scien…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
CALVIN J KUO · STANFORD UNIVERSITY · 2022 · $529,054 — PROJECT SUMMARY (Core B: Organoid Core) Infectious disease research is substantially hampered by lack of experimental models necessary to study interactions between pathogens and target tissues; a glaring deficiency amplified by the recent COVID-19 pandemic. The recent advent of 3D organoid methods …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
JOHN P. KIRWAN · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2022 · $123,969 — Project Summary: Administrative Core The LA CaTS Center Administrative Core has been set up to promote, support, and continually evolve the governance and administrative structure of the Center, to effectively facilitate the necessary leadership, tools and processes required to integrate and align …