Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Aravind Iyer · NATIONAL LIBRARY OF MEDICINE · 2020 · $1,458,093 — The origin of eukaryotes was marked by the emergence of several novel subcellular systems. One such is the calcium (Ca2+)-stores system of the endoplasmic reticulum, which profoundly influences diverse aspects of cellular function including signal transduction, motility, division, and biomineralizat…
Anton Simeonov · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2020 · $153,460 — Phage display is one of most effective molecular diversity techniques, it has been used for the selection of antibodies from diverse libraries. Several facilities (Uchicago, Utoronto, UCSF) in the world have built automated phage display robot for generation of conventional antibodies to the proteom…
Jason Matthew Elinoff · CLINICAL CENTER · 2020 — Severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), a novel coronavirus identified in December 2019, is now responsible for an expanding pandemic resulting so far in more than 300,000 deaths worldwide. While hypoxic respiratory failure due to SARS-CoV2 pneumonia is the most common presentat…
Audray Harris · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $37,194 — Coronaviruses remain both a seasonal health burden and pandemic threat due to the antigenic variation of viral glycoproteins and the ability of animal coronaviruses to cause zoonotic infections in humans. Although conserved epitopes have been identified, there is a fundamental gap in understanding a…
Tongqing Zhou · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $317,422 — An understanding of the serum responses of virus-infected individuals and vaccinees is critical for the development of effective vaccines against HIV-1, SARS-CoV-2 and other viral pathogens. Perhaps the most important biological aspect of a serum response is its neutralizing activity, with a close s…
IRWIN M CHAIKEN · DREXEL UNIVERSITY · 2020 · $74,282 — SUMMARY HIV-1 is the causative agent of AIDS, which remains a global pandemic. The need continues for more effective and broadly active preventive strategies and anti-retroviral therapies to target infectious virus and already- infected cells. In both virus-cell and cell-to-cell infection, the metas…
IRWIN M CHAIKEN · DREXEL UNIVERSITY · 2020 · $345,500 — SUMMARY HIV-1 is the causative agent of AIDS, which remains a global pandemic. The need continues for more effective and broadly active preventive strategies and anti-retroviral therapies to target infectious virus and already- infected cells. In both virus-cell and cell-to-cell infection, the metas…
ALLAN I LEVEY · EMORY UNIVERSITY · 2020 · $1,017,042 — The Open Drug Discovery Center for AD (Open-AD) Structural Biology core aims to provide Target Enabling Packages (TEPs): a combination of experimental tools and knowledge that will allow researchers to investigate the biology of potential drug targets and to test therapeutic hypotheses. The TEPs wil…
ELLIS L REINHERZ · DANA-FARBER CANCER INST · 2020 · $1,289,808 — ABSTRACT There are only a handful of sites on the HIV-1 envelope protein that represent regions of vulnerability for elicitation of broadly neutralizing antibody (BNAbs). Four are associated with the gp120 subunit while one of the sites resides in the membrane proximal external region (MPER) of …
Jason Scott McLellan · UNIVERSITY OF TEXAS AT AUSTIN · 2019 · $613,032 — Coronaviruses have the largest genomes among known RNA viruses and are phylogenetically divided into four genera. Some betacoronaviruses, such as HKU1, circulate annually in humans and cause mild yet prevalent respiratory disease whereas others, such as SARS-CoV and the recently emerged MERS-CoV, ha…
Erik S Welf · UT SOUTHWESTERN MEDICAL CENTER · 2019 · $116,100 — DESCRIPTION (provided by applicant): A greater understanding of the mechanisms mediating melanoma metastasis is necessary for treatment of advanced disease. Because all melanoma cells must move through and survive in non-native tissue microenvironments during metastatic dissemination, the abili…
Rebecca Michelle DuBois · UNIVERSITY OF CALIFORNIA SANTA CRUZ · 2019 · $363,921 — PROJECT SUMMARY Human astroviruses (HAstV) are a leading cause of viral diarrhea in children. Divergent HAstV strains are associated with fatal human encephalitis. Currently, no vaccines or antiviral therapies exist for HAstV infections. Our goal is to identify sites of vulnerability (Achilles' heel…
MARGARET A TITUS · UNIVERSITY OF MINNESOTA · 2019 · $357,741 — Cells migrating in tissues, including cancer cells, use filopodia to guide them through the 3D environment and increased formation of filopodia correlates strongly with the metastatic potential and invasiveness of cancer cells. Filopodia are slender actin-filled projections composed of a core of cro…
Nour Al-muhtasib · YALE UNIVERSITY · 2019 · $61,226 — The overall goal of this proposal is to investigate the role of endocannabinoid (ECB) signaling in regulating distinct cortical inhibitory synapses. Physiological brain development and function are dependent on a fine-tuned balance of synaptic excitation and inhibition. As such, dysregulation of inh…
JOSHUA M KAPLAN · MASSACHUSETTS GENERAL HOSPITAL · 2019 · $588,908 — DESCRIPTION (provided by applicant): The goal of this project is to identify cellular defects that are caused by mutations in genes linked to Autism spectrum disorders (ASD), using the C. elegans neuromuscular junction as a model. In particular, we will test two prominent models for pathophysio…
Margaret M Stratton · UNIVERSITY OF MASSACHUSETTS AMHERST · 2019 · $313,765 — PROJECT SUMMARY How does a memory outlast the lifetime of the molecule that encodes it? More than two decades ago, Francis Crick had the foresight to speculate that perhaps a multimeric protein could serve as a molecular memory by sharing its activation state with newly synthesized proteins through …
Dawn Caster · UNIVERSITY OF LOUISVILLE · 2019 · $165,780 — DESCRIPTION (provided by applicant): Up to 60% of SLE patients develop clinical evidence of kidney injury, termed lupus nephritis (LN). LN is thought to be caused by glomerular immune complex deposition activating an inflammatory cascade that injures glomerular cells, leading to proteinuria and…
Gary R Whittaker · CORNELL UNIVERSITY · 2019 · $235,500 — Project Summary/Abstract We propose to develop a subunit vaccine for MERS-CoV, using a structure-based approach targeting conserved and functionally essential domains in the stalk region of the viral spike protein. MERS-CoV itself is a currently emerging virus in humans with strong links to camels, …
Veronica A Alvarez · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · 2019 · $2,446,560 — Project A: Preclinical mouse model reveals a mechanism linking two known vulnerability factors for alcohol abuse: heightened alcohol stimulation and low striatal dopamine D2 receptors (Study accepted for publication and currently under press in Cell Reports). Alcohol produces both stimulant and sed…
PETER LEON COLLINS · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2019 · $464,780 — We previously constructed a first-generation construct called HPIV3-EbovZ GP, in which the complete genome of the JS strain of HPIV3 was modified by the addition of the EBOV GP gene in the third gene position, between the HPIV3 P and M genes. The JS strain is thought to be an attenuated HPIV3, based…