Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
DANIEL R BROOKS · RESEARCH TRIANGLE INSTITUTE · 2024 · $1,143,873 — PROJECT SUMMARY/ABSTRACT A growing number of geographically diverse regions around the world report increasing rates of chronic kidney disease of uncertain or unknown etiology (CKDu), a life-threatening condition not attributable to traditional chronic kidney disease risk factors. Yet, the etiology …
Stuart Berger · LURIE CHILDREN'S HOSPITAL OF CHICAGO · 2024 · $408,351 — This application for the "Allogeneic Human Mesenchymal Stem Cell (MSC) Injection in Patients with Hypoplastic Left Heart Syndrome: A Phase IIb Clinical Trial (ELPIS)" Clinical Coordinating Center (CCC) is collaborative with the ELPIS Data Coordinating Center (DCC) application. The CCC will have ulti…
Wen Jiang · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $539,426 — PROJECT SUMMARY Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic cancers. However, for solid tumors, CAR T cells face challenges including intratumor heterogeneity, dynamic expression of target receptors, and often the inability for T cells to traffic t…
Won Hee Lee · UNIVERSITY OF ARIZONA · 2024 · $529,969 — PROJECT SUMMARY There has been a significant decline in cancer related mortality, partly due to the emergence of molecular targeted therapies. Unfortunately, the success of these drugs including tyrosine kinase inhibitors (TKIs) has been tempered by a concomitant rise in the prevalence of cancer the…
Kayleigh Marie Voos · UNIVERSITY OF PENNSYLVANIA · 2024 · $35,788 — PROJECT SUMMARY Human variants in the submembrane cytoskeleton-associated protein ankyrin-B (AnkB) have been identified as risk factors for diabetes, obesity and cardiometabolic diseases. Mice harboring these human variants have AnkB deficiency in multiple metabolic tissues, including skeletal muscl…
John A DeSisto · UNIVERSITY OF COLORADO DENVER · 2024 · $93,872 — Project Summary The project’s overall goal is to determine important biological characteristics and investigate therapeutic options for pediatric high-grade gliomas (PHGG), the most aggressive of childhood central nervous system tumors and most common cause of childhood cancer mortality. PHGG surv…
Yongxian Qian · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $751,680 — ABSTRACT Disruption of cerebrospinal fluid (CSF) clearance pathway (glymphatic system) might contribute to development of Alzheimer's disease (AD), which is characterized by excessive deposition of toxic soluble amyloid beta (A- beta) proteins in the brain. Recent studies of mice demonstrated that i…
Robin Harris · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2024 · $312,717 — Project Summary Cell death has a critical role in human development and recovery following injury or disease. This is because dying cells produce signals that can significantly impact the behavior of the surrounding cells. The identity and consequences of these signals are diverse and context depen…
EDNA B FOA · UNIVERSITY OF PENNSYLVANIA · 2024 · $683,481 — Cognitive behavioral therapy involving exposure and ritual prevention (EX/RP) is a first-line treatment for obsessive compulsive disorder (OCD). Despite its efficacy, it remains unclear how EX/RP influences the neural mechanisms of the fear and anxiety brain networks to yield clinical improvement. M…
Stephen Graf Brohawn · UNIVERSITY OF CALIFORNIA BERKELEY · 2024 · $328,607 — PROJECT SUMMARY This project aims to understand the function and regulation of three ion channels that conduct K+ across cell membranes and belong to the two-pore domain K+ channel family. We will apply cryo-electron microscopy to determine structures of the channels in different functional states w…
LAURA C HANSON · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $524,104 — ABSTRACT Alzheimer’s disease and related dementias (ADRD) affect 5.6 million Americans at an annual cost of $157 billion. Three million Americans have late-stage ADRD with suffering caused by progressive dependency and distressing symptoms. Family caregivers experience extraordinary physical, emoti…
Matthew J Brady · UNIVERSITY OF CHICAGO · 2024 · $534,283 — PROJECT ABSTRACT The developing mammary gland (MG) is vulnerable to environmental and lifestyle risk factors that increase breast cancer (BC) burden in later adulthood. Therefore, optimizing BC prevention and care requires a lifespan approach to identify specific early life risk factors, to understa…
Austin L Brown · BAYLOR COLLEGE OF MEDICINE · 2024 · $610,229 — PROJECT SUMMARY/ABSTRACT Latino children experience increased incidence of acute lymphoblastic leukemia (ALL), as well as disparities in treatment response, relapse, and survival. However, to date, there have been few studies evaluating the impact of persistent neurocognitive symptoms on educationa…
JOSE E GARCIA-ARRARAS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · 2024 · $347,002 — Summary This proposal, entitled Increasing Diversity in Genomics for the Next generation (IDGeNe), is a proposal from the University of Puerto Rico, Rio Piedras campus in response to the NIH-GREAT call for proposals. The long-term goal of the IDGeNe program is to increase the diversity of the Genom…
Azadeh Yazdan Shahmorad · UNIVERSITY OF WASHINGTON · 2024 · $704,998 — Project summary The brain shows marked plasticity across a variety of learning and memory tasks as well as during recovery after injury. Many have proposed to leverage this innate plasticity using brain stimulation to treat neural disorders. Implementing such treatments requires advanced engineering…
Derek D Satre · KAISER FOUNDATION RESEARCH INSTITUTE · 2024 · $770,930 — PROJECT SUMMARY/ABSTRACT Combination antiretroviral therapy (ART) has led to dramatic declines in morbidity and mortality for people with HIV (PWH). However, as PWH age, the risk of cardiovascular disease (CVD) has increased, with a projected lifetime burden among PWH of 65% for men and 44% for wome…
David Tyus · UNIVERSITY OF VIRGINIA · 2024 · $14,135 — Project Summary Clostridioides difficile is a Gram-positive bacterium responsible for more hospital-acquired infections than any other pathogen. C. difficile infection (CDI) manifests in a range of severity from diarrheal illness to death, especially in advanced aged patients. Current therapy for CD…
Kristy M Ainslie · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $332,114 — ABSTRACT Glioblastoma’s (GBM) invasive nature is part of the reason this primary brain tumor results in near 100% mortality. Even with surgical resection, radiation, and chemotherapy, the median survival remains of only 12-15 months. Tumor invasion make complete surgical resection difficult leading …
Li Ye · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $679,018 — Project Summary Obesity is a major public health problem. Modulating energy expenditure through behavioral or pharmacological intervention is a key strategy to alter energy balance and battle obesity and metabolic diseases. Targeting molecular pathways underlying the cold-induced non-shivering therm…
LORENZ P. STUDER · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $635,667 — Project Summary Human embryonic (hESC) and human induced pluripotent stem cells (hiPSC) offer great promise for basic research and for applications in disease modeling. The initial challenge for exploiting this potential was to direct stem cell differentiation towards specific nerve cell or glial fa…