Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
STEFAN FESKE · FEDERATION OF AMER SOC FOR EXPER BIOLOGY · 2024 · $21,000 — SUMMARY This proposal requests funds to support the FASEB Science Research Conference (SRC) on "Channels and Transporters in Immunity" (CTI) that will be held from June 14–20, 2024 in St. Paul, MN. FASEB SRCs are one of the leading conference series that bring together scientists from all over the w…
Shahab Asgharzadeh · CHILDREN'S RESEARCH INSTITUTE · 2024 · $752,969 — PROBLEM. Pediatric tumors represent a very heavy social and economic burden with profound emotional involvement not only for the directly affected children but also for their family and friends. Within pediatric tumors, neuroblastoma (NB) is of particular relevance, since it is the most common solid…
Chuchu Li · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $294,484 — Alzheimer’s disease (AD) is known to cause subtle changes in language production years before diagnosis, yet current behavioral tests take limited advantage of linguistic tools to diagnose AD at early stages. Most language tasks focus on single word production (e.g., picture naming), missing many cr…
Mark Eugene Snyder · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $715,793 — Project Summary Lung transplantation remains the only definitive treatment for many patients with end stage lung disease. However, the outcomes after lung transplant are meager when compared to other solid organ transplants, with a median survival of only 6 years. The major limiting factor to long-t…
Jia Fang · ROSWELL PARK CANCER INSTITUTE CORP · 2024 · $381,884 — Project Summary Dissecting the Mechanism of SETDB1 and its K867 Monoubiquitination in Lung Cancer Progression Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related mortality worldwide and associated with high mutation burdens. During the last decade, biomarker-driven tar…
Chin Hur · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $488,626 — The goal of the project is to diminish the morbidity and mortality associated with esophageal cancer as patients with this cancer continue to suffer from extremely poor survival and high case-fatality rates. Esophageal adenocarcinoma (EAC) is the most common histologic type of esophageal malignancy …
REBECCA L LAMASON · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2024 · $558,165 — PROJECT SUMMARY/ABSTRACT A subset of emerging, but poorly characterized tickborne diseases in the U.S. are caused by Spotted Fever Group (SFG) Rickettsia. These obligate intracellular bacterial pathogens cause mild-to-life-threatening vascular diseases in humans and have a limited set of diagnostics…
JoAnne L. Flynn · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $739,545 — Despite major advances in global health care, there were an estimated 1.5 millions deaths and 10 million new cases of tuberculosis (TB) in 2018. Nearly 1 million people living with HIV developed tuberculosis (TB). Co- infection with HIV and TB is associated with high morbidity and mortality and trea…
Greg M. Delgoffe · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $640,384 — PROJECT SUMMARY/ABSTRACT The successes of immunotherapies like blockade of co-inhibitory `checkpoint' molecules have changed the treatment paradigm of cancer. However, the fact that robust responses are restricted to a subset of patients highlights the need to further understand the biology of exhau…
Jordan Jacobelli · UNIVERSITY OF COLORADO DENVER · 2024 · $483,012 — Lymphocytes must correctly localize to mount effective immune responses. To do this, lymphocytes migrate through tissue environments with very different biophysical characteristics, including extravasation from blood vessels and crawling through cell-packed or extracellular matrix-rich tissues. To n…
CHRISTOPHER KLUG · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $284,416 — (PLEASE KEEP IN WORD, DO NOT PDF) Significant progress has been made in identification of key components of the adult bone marrow (BM) mesenchymal stromal cell (MSC) niche that are critical for maintaining the function of rare, long-term self-renewing hematopoietic stem cells (LT-HSC). In particular…
Wei-Jun Qian · BATTELLE PACIFIC NORTHWEST LABORATORIES · 2024 · $949,078 — Project Summary/Abstract: Type 1 diabetes (T1D) is a devastating disease often occurring in children and young adults resulting from the autoimmune-mediated loss of pancreatic β-cells. It has been challenging for monitoring the disease progression and the efficacy of clinical interventions. Therefor…
Chandler Scott Cortina · MEDICAL COLLEGE OF WISCONSIN · 2024 · $210,062 — PROJECT SUMMARY/ABSTRACT In the U.S., an estimated 1.4 million people identify as transgender (TG), defined as a person whose gender is different than their sex assigned at birth, and are a designated minority population by the NIH (NOT-MD-19-001). Many TG persons take gender-affirming hormone thera…
Anita Juliane Huttner · YALE UNIVERSITY · 2024 · $1,589,662 — ABSTRACT Alzheimer’s disease (AD) is the leading cause of dementia (60-80%), affecting tens of millions of people globally and, due to longer lifespans and aging populations, perhaps hundreds of millions more by 2050. AD pathology is first observed in allocortical and limbic areas within the cerebru…
David Victor Smith · TEMPLE UNIV OF THE COMMONWEALTH · 2024 · $650,575 — Project Summary Older adults are often victims of financial exploitation, which results in annual losses of at least $3 billion. Threat of exploitation may be greater in those at risk for Alzheimer's Disease and Related Dementias (ADRD). While most cases of financial exploitation are perpetrated by …
Megan E Huibregtse · EMORY UNIVERSITY · 2024 · $81,784 — PROJECT SUMMARY Women experience worse symptoms and outcomes following traumatic brain injury (TBI), contrary to the consensus in preclinical research that female sex hormones confer neuroprotection. Multiple mechanisms have been proposed to drive this health disparity, including hormonal fluctuatio…
Amelia N Deitchman · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $201,150 — Project Summary/Abstract For the nearly 37 million people living with HIV (PLWH), functional cure, or antiretroviral (ART)-free remission, is rapidly becoming an attainable target. While extensive research on the mechanisms underlying immune dysfunction and viral persistence present promising opport…
Peng Jiang · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2024 · $495,815 — Abstract: An estimated ~1.3 million adults and adolescents are living with human immunodeficiency virus (HIV) infection in the USA of which 15% of them undiagnosed. The initiation of combination antiretroviral therapy (cART) has transformed AIDS from a fatal illness into a chronic and manageable dis…
John A Moss · OAK CREST INSTITUTE OF SCIENCE · 2024 · $886,859 — PROJECT SUMMARY Pre-exposure prophylaxis (PrEP) using orally or topically delivered antiretroviral (ARV) drugs can prevent HIV infection in susceptible, uninfected individuals. Adherence to the daily or monthly dosing regimens, however, has emerged as a critical factor driving the clinical success o…
Sharad A. Ghamande · AUGUSTA UNIVERSITY · 2024 · $1,047,137 — Abstract: Augusta University has been home to Georgia’s NCI Community Oncology Research Program since 2014. In partnership with University Blood and Cancer Center in Athens, Phoebe Putney Medical Hospital in Albany, Augusta Oncology Associates in Augusta, and Dwight D. Eisenhower Army Medical Center…