Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Dustin T Duncan · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $774,324 — PROJECT SUMMARY To address the aims of the proposed research and RFA-HL-21-018, we will use a syndemics and multi-level approach to investigate relationships between sleep and HIV treatment outcomes and behaviors (e.g., viral suppression and retention in care) cross-sectionally and longitudinally am…
Erin Flaherty · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $131,733 — PROJECT SUMMARY During development, individual neurons extend highly branched neurites that innervate the surrounding territory with minimal overlap. In mammals, the clustered protocadherins (Pcdh) provide each neuron with a unique cell specific identity required for self-identification and self-av…
Jacklyn Donna Foley · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $195,772 — PROJECT SUMMARY In this K23 proposal, I outline a comprehensive five-year training program that will prepare me for the transition to an independent, R01 level investigator capable of developing novel, feasible, and scalable integrative behavioral interventions to reduce psychological and cardiovasc…
Mohammed Adnan Mohammed Hanif Qureshi · NEMALIFE INC. · 2024 · $322,070 — Project Abstract Alcohol use disorders (AUDs) are globally prevalent neurobehavioral disorders where individuals consume excessive alcohol despite its adverse effects on their lives. The global incidence of deaths related to AUDs was estimated at 3 million in 2016, while in the US, 140,000 deaths an…
YOW-PIN LIM · PROTHERA BIOLOGICS, LLC · 2024 · $987,396 — The primary goal of this proposed research is to develop a rapid point-of-care (POC) test, based on Inter-alpha inhibitor Proteins (IAIP) levels in blood, that assesses the risk of neonatal sepsis (NS) and/or necrotizing enterocolitis (NEC) in infants. NS and NEC are associated with high mortality, …
German Gustavo Gornalusse · UNIVERSITY OF WASHINGTON · 2024 · $829,396 — ABSTRACT Despite the effectiveness of antiretroviral treatment (ART) at treating HIV, it fails to completely eradicate the viral reservoir. HIV reactivation occurs naturally, as evidenced by occasional low-level viremia (“blips”) observed in patients on ART. Studying the anatomical sites of HIV reac…
Steven Edward Johnson · DURAMETRIX LLC · 2024 · $1,011,661 — PROJECT SUMMARY There is a substantial and growing need for in vivo toxicity testing, as in drug R&D it is critical to be able to understand toxicity and to identify and eliminate overly toxic candidates. We developed an imaging-based approach that detects toxicity-induced tissue injury in a minimal…
Howard Levin · CORIDEA, LLC · 2024 · $274,839 — PROJECT SUMMARY: Sepsis is one of the leading sources of morbidity and mortality in the US, impacting nearly 1.7 million adults each year and upwards of 250,000 deaths annually. Septic shock is sepsis characterized by hemodynamic failure, with exceptionally high mortality ranging from 15-70%. Septic…
Erol Fikrig · L2 DIAGNOSTICS, LLC · 2024 · $298,362 — ABSTRACT This Phase I proposal seeks to improve a novel vaccine for human use against pathogens transmitted by the blacklegged tick, Ixodes scapularis. In previous studies, we proposed that vaccine targeting of tick salivary proteins (Salps) critical for tick feeding would impair tick feeding and co…
Aditya Raguram · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · 2024 · $487,500 — 7. PROJECT SUMMARY/ABSTRACT Many emerging therapeutic strategies employ macromolecules, like proteins or RNAs, to manipulate intracellular contents and processes, thus mitigating disease. The success of these therapeutic strategies requires the ability to safely and efficiently deliver macromolecul…
Samuel Hickenlooper · LUMINARY THERAPEUTICS, INC. · 2024 · $399,256 — Abstract CAR T cell therapies have produced robust remissions in several hematological malignancies. However, they have not achieved the same success against solid tumors. These treatments fail for multiple reasons, including antigen escape and poor T cell persistence in the immunosuppressive tumor …
Timothy S McConnell · ATLASXOMICS INC. · 2024 · $399,929 — In this Phase I SBIR study, AtlasXomics will develop a next-generation spatial deposition process to expand tissue type compatibility, minimize end-user processing, and allow adaptation into larger automation workflows. Epigenetics is critical in regulating gene expression in healthy and diseased ti…
Jon Andrew Corkey · AMISSA, INC. · 2024 · $1,419,714 — Project Summary Last year, the care and treatment of roughly 6 million people diagnosed with Alzheimer's disease and related dementias cost the U.S. approximately $593 billion dollars. The tremendous costs associated with Alzheimer's disease include direct medical costs, such as doctor visits, hospi…
ALICE S AMMERMAN · EQUITI FOODS, LLC · 2024 · $295,923 — Diet-related disparities are attributed to factors experienced by historically disadvantaged communities, such as inadequate access to healthy food and socio-economic stressors. Poor quality diets have contributed to high rates of chronic disease, with nearly 50% of adults suffering from diet-relate…
Dennis Bong · OHIO STATE UNIVERSITY · 2024 · $333,832 — PROJECT SUMMARY/ABSTRACT We propose herein a methodology to identify synthetic peptide-based binders to non-canonical structural motifs in RNA. Reagents that selectively target these biologically important motifs would be transformative theranostic tools for study and modulation of RNA-governed biol…
AIMEE S JAMES · WASHINGTON UNIVERSITY · 2024 · $461,980 — PROJECT SUMMARY/ABSTRACT Many rural communities are medically underserved and experience persistently elevated rates of colorectal cancer (CRC) incidence and mortality relative to declining national rates. Routine screening reduces population CRC mortality, yet its impact is reduced because many adu…
Lauren Kupis · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $40,967 — Abstract Autism spectrum disorder (ASD) affects one in 44 children. 1 Early diagnosis is critical for optimizing outcomes, yet children are not typically diagnosed until 4 years of age.2 In concert with early behavioral signs, early neural markers could identify toddlers at risk of developing ASD to…
Rachel Miller Radin · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $172,098 — Project Summary/Abstract A critical problem facing behavioral weight-loss interventions for adults with obesity is the tendency towards weight regain following weight loss. This is due in part to a failure to address the behavioral lynchpins that underlie obesity for a significant subset: overeating…
STEPHEN Lev HOFFMAN · SANARIA, INC. · 2024 · $277,702 — In 2022 WHO called for highly efficacious vaccines against malaria that prevent Plasmodium falciparum (Pf) infection in > 90% of recipients. Alone among malaria vaccines, Sanaria® PfSPZ (Pf sporozoite (SPZ)) vaccines have shown > 90% vaccine efficacy (VE) against controlled human malaria infection a…
ROBERT S. SANDLER · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $585,867 — PROJECT SUMMARY Microscopic colitis is the most common cause of chronic watery diarrhea in older adults. The symptoms of this disease are debilitating. Patients describe isolation and withdrawal from social life and activities. Treatment is limited to expensive therapies that are sometimes ineffecti…