Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Alexandrea L. Craft · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · 2024 · $437,475 — PROJECT SUMMARY / ABSTRACT Preterm infants are at a heightened risk for developing neuromotor, cognitive, and psychiatric disorders that persist through adulthood. Infants born very preterm (<32 weeks gestational age) are three times more likely to develop psychiatric disorders, including anxiety, A…
Stephanie Caroline Eisenbarth · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $798,975 — PROJECT SUMMARY The goal of this proposal is to identify new ways of preventing anaphylaxis in those with food allergy by defining cellular and molecular mechanisms that transport intact food allergens across the gut epithelium. In its most severe form, food allergy can trigger life-threatening anap…
HEIDI A TISSENBAUM · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $209,375 — Project Summary/Abstract Our population is aging. As our population ages, the incidence of Alzheimer’s Disease (AD), an age-associated illness, grows, resulting in elevated health care costs. A second factor contributing to the current rise in age-associated aliments is the American diet with its ev…
Haesuk Park · UNIVERSITY OF FLORIDA · 2024 · $651,976 — PROJECT SUMMARY/ABSTRACT Hepatitis C virus (HCV) infection has markedly increased in the United States, primarily resulting from injection drug use (IDU) associated with the ongoing opioid epidemic. Furthermore, >50% of 3.2 million individuals with chronic HCV remain undiagnosed, leading to signific…
Tian Ge · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $732,244 — Impaired higher-order cognition is well-documented in different forms of neuropsychiatric illness, present in unaffected relatives, often presumed to underlie behavioral symptoms, and associated with functional outcome. Cognition is thus exceedingly relevant to studies of the etiology and trajectory…
Samuel Brill · COLORADO STATE UNIVERSITY · 2024 · $48,974 — Project Summary This proposal aims to train a dual-degree, DVM-PhD student for a career as a lab animal veterinarian and independent scientist. The research outlined in this proposal will develop a pre-clinical platform to evaluate CAR-T therapy in a canine model. Chimeric antigen receptor (CAR)-T c…
Dritan Agalliu · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $540,496 — PROJECT SUMMARY Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide due to its heterogeneity and complex mechanisms of pathogenesis. Clinical outcomes following TBI are determined by the nature and severity of the primary injury as well as activation of the pe…
SEUNGHEE CHA · UNIVERSITY OF FLORIDA · 2024 · $598,932 — ABSTRACT Through our multidisciplinary clinical and research collaboration, we have established a rare cohort of children and adolescents who fulfilled the 2016 adult Sjögren’s disease (SjD) criteria (namely, cSjD for childhood Sjögren’s disease). Since autoimmune SjD typically affects elderly femal…
Stephanie Manasse · DREXEL UNIVERSITY · 2024 · $664,491 — ABSTRACT Overweight/obesity (OW/OB) affects 14 million adolescents in the United States, disproportionately affecting girls and racial/ethnic minorities, increasing their risk of cardiovascular disease and type 2 diabetes. Behavioral weight loss interventions are the foundation of obesity treatment …
Brendan Adkinson · YALE UNIVERSITY · 2024 · $33,892 — PROJECT SUMMARY Nearly one-fifth of the Unites States population resides in a rural region, and approximately one-fifth of those residents suffers from a mental illness. While these rates of mental illness are similar to urban areas, individuals living in rural regions face a disproportionate burde…
Yolanda Sanchez · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2024 · $2,300,943 — ABSTRACT: The overarching goal of the University of New Mexico Comprehensive Cancer Center (UNMCCC) Cancer Research Training and Education Coordination Core (CRTECC) is to prepare a diverse group of trainees to conduct cancer research in the context of laboratory, clinical, and community settings …
CHAD A. MIRKIN · NORTHWESTERN UNIVERSITY · 2024 · $490,839 — PROJECT SUMMARY/ABSTRACT This research will utilize spherical nucleic acid (SNA) nanostructures to develop effective, structure-informed vaccines for advanced melanoma. Traditional treatments (i.e. chemotherapy or radiation) are less successful for melanoma because of difficulties in discerning mela…
Neelendu Dey · FRED HUTCHINSON CANCER CENTER · 2024 · $1,577,081 — SUMMARY Colorectal cancer (CRC) affects ~145,000 people/year in the US and is the 3rd most common cause of cancer related deaths. CRC arises from early lesions that are pre-cancerous; these early lesions are colon adenomas and serrated sessile lesions (SSL). Colon adenomas account for 80-85% of the …
Alan Teo · PORTLAND VA MEDICAL CENTER · 2024 — Background: Suicide is an urgent public health crisis, and transitioning Veterans (those who have recently separated from the military) are a high-risk group for suicide. A key component to advancing suicide prevention efforts among at-risk Veterans is to address low levels of help-seeking and engag…
Christie Befort · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $2,294,953 — PROJECT SUMMARY/ABSTRACT: OVERALL COBRE on Implementation Science & Equity Shrinking the time lag for translating research evidence into clinical practice would improve health outcomes across multiple domains and reduce costs to society. Until recently, however, clinical research has devoted little …
LORRAINE J GUDAS · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $434,366 — Abstract Despite intensive treatments that often combine surgery, chemotherapy, and radiation, patients with head and neck squamous cell carcinomas (HNSCCs), including oral cavity and esophageal squamous cell carcinomas (OCSCCs & ESCCs), have a long-term survival rate of only 15-40%. Among the reaso…
Susan Mazanec · CASE WESTERN RESERVE UNIVERSITY · 2024 · $440,890 — Project Summary/Abstract: Patients with head and neck, lung, esophageal, rectal, and anal cancers typically undergo rigorous, intense, combined-modality treatment (radiation, surgery, and/or chemotherapy) and experience high symptom burden, functional impairment, and complex psychosocial issues. Pos…
BRUCE A. BERKOWITZ · WAYNE STATE UNIVERSITY · 2024 · $1,086,200 — Therapeutically delaying the progressive decline in cognition in patients with Alzheimer’s disease (AD) would transform AD into a manageable morbidity, a goal that has not been achieved using drugs targeted to β-amyloid (Aβ) plaque deposition. Accumulating results indicate that cognitive loss (linke…
Erik D. Storholm · SAN DIEGO STATE UNIVERSITY · 2024 · $630,223 — SUMMARY/ABSTRACT Transgender and non-binary (TGNB) persons experience intimate partner violence (IPV) at alarming rates twice that of their cisgender peers. Prior work has linked IPV to sexual risk behavior and increased risk for HIV seroconversion among TGNB, but less is known about the impact of I…
John Ross Rizzo · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $264,010 — PROJECT SUMMARY/ABSTRACT Visual impairment causes significant losses to mobility, independence, and quality of life, contributing to elevated rates of anxiety, depression, and physical injuries, inclusive of mechanical trips and falls. These challenges are compounded in complex urban environments, …