Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
MARILYN S. ALBERT · JOHNS HOPKINS UNIVERSITY · 2024 · $1,309,997 — Project Summary/Abstract: Small-vessel-related vascular contributions to cognitive impairment and dementia (VCID) represent the second leading cause of cognitive dysfunction in older individuals. However, quantitative biomarkers indexing key vascular processes related to VCID that are suitable for …
Jonathan Greenberg · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $157,939 — Project Summary This K23 proposal details a comprehensive 5-year training program that will support the candidate’s transition toward an independent clinical research career focused on the development and rigorous testing of mind-body interventions with an emphasis on prevention of transition from a…
Emmanuel J Mignot · STANFORD UNIVERSITY · 2024 · $623,609 — Abstract Novel neuroimmune disorders defined by the presence of autoantibodies in plasma and/or CSF have recently been discovered, most often first described in the context of paraneoplastic syndromes, only later to be also found unassociated with tumors. These include limbic encephalitis (e.g., ant…
Krzysztof Kiryluk · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $805,207 — PROJECT SUMMARY Chronic kidney disease (CKD) is a common complex condition associated with high morbidity and mortality, with a prevalence estimated at 13% in the U.S. that continues to increase annually. The etiology of CKD is complex, with both genetic – including monogenetic and polygenic – and e…
Jasara Hogan · NEW YORK UNIVERSITY · 2024 · $195,480 — PROJECT SUMMARY/ABSTRACT The proposed K23 Mentored Patient-Oriented Research Career Development Award will provide the applicant with necessary training and hands-on experience to successfully transition to independence in alcohol research. Dr. Hogan will learn the intricacies of alcohol administra…
Akram Bakkour · UNIVERSITY OF CHICAGO · 2024 · $566,465 — Project Summary Anorexia Nervosa (AN) is a serious eating disorder with a mortality rate among the highest of any psychiatric illness. Identifying modifiable targets for the development of novel AN interventions is crucial because leading treatments achieve remission rates of less than 50%, and rela…
Zachary Aaron Graham · BIRMINGHAM VA MEDICAL CENTER · 2024 — Unloading and paralysis of skeletal muscle after spinal cord injury (SCI) results in severe loss of muscle contractile function and deleterious alterations in mitochondrial morphology and performance. One potential mechanism is the de novo appearance of connexin hemichannels (Cx) in paralyzed muscle…
Aaloke Mody · WASHINGTON UNIVERSITY · 2024 · $193,511 — ABSTRACT Sustained retention in HIV care is critical for viral suppression, but people living with HIV (PLWH) frequently transition in and out of care over time, putting them at high risk for ongoing viremia and drug resistance. Even when PLWH return to care after loss to follow-up (LTFU), rates of …
SVETLANA PUNDIK · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · 2024 — Current rehabilitation methods fail to restore normal gait for many stroke survivors leading to dependence on others, recurrent falls, limitations in community ambulation and poor quality of life. The main objective of this study is to test both efficacy and neurophysiological mechanisms of a novel …
ROBERT A. LAFYATIS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $1,563,264 — The overall goal of this Center of Research Translation is to utilize biomarker tools and other translational research observations to discover new therapies for patients with systemic sclerosis (SSc). This goal can be broken down into four intermediate objectives: understanding pathogenic pathways …
Tayyaba Hasan · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $1,002,287 — OVERALL PROGRAM SUMMARY For optimal cancer therapy, combination approaches that are mechanistically complementary and directed at non-overlapping molecular targets are needed. Strategically, combinations should be selected such that the first treatment primes the tumor for the second treatment. Buil…
HEATHER Hammond NELSON · UNIVERSITY OF MINNESOTA · 2024 · $2,660,848 — Abstract The 10,000 Families Study (10KFS) will be a new, family-based cohort study in Minnesota, the ‘Land of 10,000 Lakes’. Due to our high incidence rates of hematologic malignancy (leukemia, lymphoma, and myelodysplastic syndromes), we will focus our proposal on environmental exposures of concer…
Gyorgy Hajnoczky · THOMAS JEFFERSON UNIVERSITY · 2024 · $421,776 — Mitochondrial Ca2+ uptake controls many cell functions, including energy metabolism, signaling and dynamics. Mitochondrial Ca2+ accumulation is supported by the robust driving force of the highly negative, inner mitochondrial membrane potential, but is activated only during Ca2+ signals, when cytopl…
Salman Ehtesham Qasim · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $17,205 — PROJECT SUMMARY How does decision-making influence memory to leave a long-lasting impact on human behavior? Answering this question is critical to understanding how impaired decision making might lead to maladaptive memory outcomes, such as rumination on negative events, susceptibility to false memo…
Sudarshan R Jadcherla · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2024 · $633,944 — PROJECT SUMMARY/ABSTRACT The prevalence of symptom-based diagnosis of gastroesophageal reflux disease (GERD), its empiric treatment, and practice variation in high-risk hospitalized infants remain high. Prior clinical trials data lack physiological- based, objective diagnostic evidence and treatment…
Justin M Riddle · FLORIDA STATE UNIVERSITY · 2024 · $249,000 — Anhedonia - the inability to seek-out and experience pleasure - is a common symptom in depression that predicts treatment resistance and is sometimes exacerbated by first-line antidepressants. Anhedonia falls within the "Positive Valence System" of the Research Domain Criteria framework that compris…
Benjamin Leland Woolbright · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $162,000 — ABSTRACT Bladder cancer (BCa) is predominantly a disease of aging with the risk of developing invasive disease peaking in the 8th decade of life. Elderly patients have higher rates of co-morbidities and are thus often not suitable candidates for standard of care surgery and/or chemotherapy or immuno…
Leslie S Babonis · CORNELL UNIVERSITY · 2024 · $392,500 — The specialization of somatic cell types for unique functions is arguably the most important driver of physiological complexity in animals. Key innovations in subcellular structure, including the development of a specialized secretory vesicle, increased the evolvability of cells and provided new opp…
Andrew Volk · CINCINNATI CHILDRENS HOSP MED CTR · 2024 · $397,500 — PROJECT SUMMARY: Comprehensive regulation of transcription is a major mechanism by which immature cells functionally determine their identity. The epigenetic factors responsible for this transcriptional regulatory activity are some of the most potent, and most commonly mutated, factors implicated i…
RICHARD H. FINNELL · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $695,911 — ABSTRACT: UNDERSTANDING GENETIC COMPLEXITY IN SPINA BIFIDA Among neural tube defects (NTDs), myelomeningocele (spina bifida:SB), is a devastating but survivable, human structural malformation. Up to 70% of SB cases are attributed to genetic predisposition, with intrauterine environment precipitatin…