Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Lifang Hou · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $258,937 — PROJECT SUMMARY The Northwestern University (NU) and Mali’s University of Sciences, Techniques, and Technologies of Bamako (USTTB)’s Infection-Associated Cancer (NM-IAC) Research Training Program addresses a National Cancer Institute (NCI) high research priority and a significant and growing source …
Vera Borkowski · VANDERBILT UNIVERSITY · 2024 · $31,709 — PROJECT SUMMARY Social determinants of health (SDoH) are associated with poor health outcomes and health disparities. The National Academies of Sciences, Engineering, and Medicine’s Future of Nursing Report encourages clinicians to address SDoH, which are the environmental conditions in which people…
Steven P. Balk · DANA-FARBER CANCER INST · 2024 · $2,393,890 — PROJECT SUMMARY – OVERALL The Dana-Farber/Harvard Cancer Center (DF/HCC) Prostate SPORE seeks to improve the understanding and treatment of prostate cancer using a highly translational approach. The application consists of three Projects, three Cores, a Developmental Research Program and a Career En…
John A Rathmacher · MTI BIOTECH, INC. · 2024 · $957,913 — PROJECT SUMMARY Although the ubiquity of metabolic problems in pulmonary hypertension (PH) has been known for more than a decade, a wealth of new details on the nature of this problem presents the opportunity for intervention. A combination of experimental work in cells and animals and early trials …
Luu Van Pham · JOHNS HOPKINS UNIVERSITY · 2024 · $195,806 — PROJECT SUMMARY Sleep disordered breathing (SDB) is a highly prevalent disease that is associated with increased risk for incident diabetes. Mechanisms of SDB-induced dysglycemia have not been elucidated. Hypoxemia has been implicated as a key pathogenic factor in the development of glucose intolera…
Harsimranjit S Sekhon · UPSTATE MEDICAL UNIVERSITY · 2024 · $53,974 — PROJECT SUMMARY CMV disease is the largest cause of post-transplant patient mortality. After a transplant, patients have to undergo extensive screening and prophylactic therapy in order to prevent reactivation of the virus. In many cases, even if these precautions are taken, the virus will reactiva…
Gerta N/A Hoxhaj · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $328,000 — SUMMARY: To grow and proliferate, cells need to fulfill three key metabolic demands: increased biosynthesis, sufficient energy supply, and maintenance of redox homeostasis. The latter demand is particularly important for sustained growth, because increased rate of cellular metabolic activity during …
Kathleen Lombard Poston · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $603,714 — ABSTRACT Parkinson’s disease (PD) is a devastating, progressive neurodegenerative brain disease, with no known cure. The disease afflicts 10 million people worldwide - ~1.5 million in the U.S. alone, and ~50k-60k new cases are diagnosed annually. Risk factors or interventions are extremely hard to e…
Jodi A. Flaws · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $478,676 — Project Summary The goal of the NIMG R25 IPERT program is to support educational activities that complement and/or enhance the training of a workforce to meet the nation’s biomedical, behavioral and clinical research needs. This funding opportunity encourages activities and outreach programs with a …
Karla Fitzgerald Leavens · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $113,726 — Project Summary In order for the b-cell to precisely secrete insulin in response to glucose, glucose metabolism to ATP is tightly coupled to insulin secretion through the ATP-sensitive K (KATP) channel. Any disruption along this pathway leads to b-cell dysfunction and ensuing diabetes or, more rare…
HAFIZ AHMED · GLYCOMANTRA, INC. · 2024 · $1,864,171 — Project Summary/Abstract Obesity-mediated insulin resistance is a hallmark of type 2 diabetes (T2D), which accounts for ~90% of all diabetes. Despite many drugs that are available to treat T2D, there is no FDA-approved drug that directly works on the insulin receptor (IR) to overcome insulin resista…
Wei Tong · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $604,938 — Summary The temporal and spatial distribution of signaling proteins is dynamically regulated by post-translational modifications (PTMs). PTMs such as phosphorylation, ubiquitination, or lipid modification dictate protein activities and access to substrates, thereby cellular outcomes. The precise con…
Bethany Hedt-Gauthier · HARVARD MEDICAL SCHOOL · 2024 · $267,459 — Project Summary/Abstract Increased access to cesarean sections (c-sections) has contributed to the decline of maternal mortality in sub- Saharan Africa (SSA); however, as the rate of c-sections has increased, so has the rate of c-section related complications. While women who deliver vaginally in ru…
Liangcai Gu · UNIVERSITY OF WASHINGTON · 2024 · $851,525 — ABSTRACT Comprehensive identification and characterization of senescent cells in morphologically intact human tissues is important for understanding senescence in vivo and the targeted removal of these cells to improve healthspan and lifespan. This task has been challenging due to the lack of univer…
Nikej Shah · NIRSUM LABORATORIES, INC. · 2024 · $3,051,459 — PROJECT SUMMARY The ongoing epidemic of opioid use disorder (OUD), overdose, and death is unprecedented. Available pharmacologic therapies for OUD have failed to stem the tide, plagued by poor adherence and retention, the principal factors associated with relapse and treatment failure. Over 80% of i…
Jason Cobb · EMORY UNIVERSITY · 2024 · $120,183 — PROJECT SUMMARY The Summer Undergraduate Program in Emory Renal Research (SUPERR) will promote an appreciation for the study of kidney, urology, and hematologic (KUH) diseases among undergraduate students who are interested in furthering their scientific research and could be encouraged to pursue a …
Khadijah Breathett · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $683,713 — ABSTRACT Standardized protocols can reduce the impact of implicit bias but are underused. Since the Institute of Medicine’s report, “Unequal Treatment”, multiple studies have confirmed that standardization of decision- making processes reduces bias, but bias in the allocation of advanced therapies h…
Sarah Louise Brown · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $22,726 — Project Summary/Abstract The goal of this F32 fellowship project and training plan is to prepare the candidate to independently conduct innovative research aimed at improving our understanding of suicide risk and preventing suicidal behaviors (SB) in high-risk populations. Despite decades of suicide…
Martin Tran · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2024 · $48,974 — Project Summary/Abstract The overarching goal of this proposal is to understand how the stereotypical structure of retina forms during embryonic development. Towards this goal, this proposal seeks to develop novel molecular recording technologies that allow the reconstruction of lineage history bas…
Nicole Hamagami-Samson · WASHINGTON UNIVERSITY · 2024 · $48,785 — Project Summary: Human genetic studies have linked autism and related neurodevelopmental disorders (NDD) to disruption of genes encoding epigenetic factors. While mutations in these genes can affect more than one pathway that leads to ASD, identification of a common molecular pathway across genetic …