Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Natalia Nieto · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $495,418 — Non-alcoholic steatohepatitis (NASH) is emerging as a major worldwide cause of liver disease in children and adults. Recent studies demonstrate substantial heterogeneity in the phenotype of macrophages (MFs) infiltrating the liver during NASH. Recruited MFs exist as two subsets, with distinct activa…
Ira J Goldberg · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $844,212 — ABSTRACT Diabetes markedly increases risk of development of atherosclerotic cardiovascular disease (CVD). Human and animal data also show that diabetes prevents the normal repair of damaged arteries that occurs upon circulating LDL cholesterol (LDL-C) reduction. Because of this, patients with diabet…
Jacob O Brunkard · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $320,956 — PROJECT SUMMARY TARGET OF RAPAMYCIN (TOR) is a deeply conserved protein kinase that regulates eukaryotic metabolism. TOR senses and integrates upstream signals, especially nutrient availability, to coordinate metabolism and promote growth only when conditions are favorable. TOR dysregulation causes…
Laura Cheney · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $194,400 — Project Summary/Abstract This proposal presents a 4 year research career development program focused on the study of macroautophagy (autophagy) in the context of HIV associated neurocognitive disorders (HAND) to increase the understanding of HAND pathogenesis with the goal of identifying targets for…
Jennifer Y. Chen · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $548,064 — ABSTRACT Fibrosis is the final common pathway in chronic liver disease that leads to liver failure, and is characterized by an imbalance of extracellular matrix (ECM) deposition and remodeling. There are currently no FDA-approved therapies to target this endpoint of chronic liver disease. Moreover, …
Gregory W Carter · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $6,287,895 — PROJECT SUMMARY OVERALL Alzheimer’s disease (AD) is a devastating neurodegenerative disorder affecting nearly 6 million Americans and is expected to increase over the next several years. Our limited understanding of the mechanisms that trigger the emergence of AD has contributed to the lack of inte…
MALLORY A PERRY-EADDY · UNIVERSITY OF CONNECTICUT STORRS · 2024 · $249,000 — PROJECT SUMMARY/ABSTRACT Sepsis in children is a leading cause of death and morbidity, yet little is known about its impact on physical function after hospital discharge. Building upon the candidate’s prior biobehavioral research, this proposed K99/R00 application will utilize symptom science approa…
Roxana Cristina Chicas · EMORY UNIVERSITY · 2024 · $148,339 — PROJECT SUMMARY Roxana Chicas, PhD, RN is a 1st generation bilingual Latina and her goal is to become an independent NIH- funded nurse scientist developing a sustainable research program in the area of glucose metabolism and kidney disease. Support from the K23 award will provide the dedicated resea…
Wenwen Fang · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $418,750 — PROJECT SUMMARY Specific recognition of double-stranded RNA (dsRNA) structures underlies key biological processes from development to antiviral immune responses, and involves a host of dsRNA- binding proteins. Biochemical and structural studies have delineated how these proteins interact with model …
Ran Liu · STANFORD UNIVERSITY · 2024 · $53,312 — PROJECT SUMMARY AND ABSTRACT Chronic opioid usage after surgery is a major contributor to the opioid epidemic, which poses a major crisis in public health. 51 million patients undergo surgery each year in the United States. Between 9-13% of surgical patients continue chronic use of opioids, leading …
David Antonetti · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $661,256 — PROJECT SUMMARY Stroke is a significant cause of adult disability in the US. Early treatment with thrombolytics or mechanical thrombectomy can significantly improve neurological outcomes in patients with acute ischemic stroke. However, following these acute interventions long term recovery care is p…
Amy Carolyn Conaway · DARTMOUTH COLLEGE · 2024 · $48,974 — ABSTRACT Pseudomonas aeruginosa (Pa) frequently co-infects with other bacterial and fungal species. For example, 50% of adults with cystic fibrosis (CF) are chronically infected with Pa and Candida albicans (Ca) commonly co- infects. Antagonistic interactions between Pa and Ca can enhance the growth…
Jacob Gadwa · UNIVERSITY OF COLORADO DENVER · 2024 · $37,384 — Abstract Head and neck squamous cell carcinoma (HNSCC) and pancreatic adenocarcinoma (PDAC) differ in many of the genetic drivers, low responsiveness to immunotherapy remains a commonality shared between both. Resistance to therapy remains an issue and while the field awaits results from numerous on…
Alec Stepanian · TUFTS UNIVERSITY BOSTON · 2024 · $44,724 — PROJECT SUMMARY/ABSTRACT The development of first generation Abl-tyrosine kinase inhibitor (Abl-TKI) imatinib (Im) to treat chronic myelogenous leukemia (CML) in 2001 has changed this previously lethal cancer into a chronic illness. Despite initial success, Im intolerance and resistance necessitates…
Roberto Hugo Barbier · DUKE UNIVERSITY · 2024 · $41,798 — ABSTRACT Prognosis for patients with small cell lung cancer (SCLC) remains poor due to high rates of metastatic disease, vast intra-tumoral heterogeneity, limited therapeutic options, and rapid development of therapeutic resistance. Our lab has recently shown that Abelson (ABL) family kinase inhibit…
Arianne Caudal · STANFORD UNIVERSITY · 2024 · $74,284 — Project Summary Type 2 diabetes (T2D) is a leading cause of death nationwide, with 65% of mortality due to cardiovascular disease. The term “diabetic cardiomyopathy (T2DCM)” refers to a condition with adverse myocardial remodeling in the absence of hypertension and vascular pathology. Although T2D a…
NAIM M MAALOUF · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $452,882 — PROJECT SUMMARY / ABSTRACT The incidence of calcium phosphate (CaP) stone disease has markedly increased over the last four decades. CaP stone formers experience high rates of stone recurrence and frequently need repeat stone surgery, indicating that current prophylactic medical regimen are suboptim…
Jill Reeves Hamilton-Reeves · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $557,517 — PROJECT SUMMARY/ABSTRACT Patients undergoing surgery to treat their bladder cancer experience persisting complications from their surgery. A lower resistance to infection and muscle wasting are common complications from the surgery. The radical cystectomy operation is not only extremely catabolic, b…
Vasantha Kolavennu Jotwani · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · 2024 · $663,944 — PROJECT SUMMARY The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated that intensive blood pressure (BP) targets significantly reduced risks of cardiovascular disease (CVD) and mortality, leading to new guidelines recommending a lower BP target of <130/80 mm Hg. However, intensive BP …
Melanie A Morrison · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $646,040 — PROJECT SUMMARY/ABSTRACT Implantable deep brain stimulation (DBS) is a second-line surgical neuromodulation for Parkinson's disease (PD) that can provide significant relief of motor symptoms when medications become less effective, however there are currently no reliable predictors of therapeutic eff…