Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Reza Dastvan · SAINT LOUIS UNIVERSITY · 2024 · $395,216 — Project Summary/Abstract The bioactive lipid sphingosine-1-phosphate (S1P) plays a key role in regulating the growth, survival and migration of mammalian cells. S1P is produced intracellularly and then released extracellularly to engage in its (patho)physiological roles. The Spinster (Spns) lipid t…
Kuei-Yuan Tseng · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $359,775 — Abstract Converging human association studies link cannabis abuse during adolescence with an increased likelihood of developing cognitive and emotional regulation deficits later in life, many of which are refined and dependent on prefrontal cortex (PFC) maturation during adolescence. However, the ne…
Daniel Ellis Hyer · UNIVERSITY OF IOWA · 2024 · $395,858 — Abstract/Summary Proton arc therapy has lagged behind photon arc therapy, which is now commonplace in the clinic, due mostly to slow proton energy switching times which make treatment durations impractical. Fast energy modulation systems are now clinically available, and, by applying delivery optimi…
Moonjung Jung · JOHNS HOPKINS UNIVERSITY · 2024 · $194,453 — Project Summary Alcohol is a common potential source of DNA damage in humans. Indeed, its metabolic byproducts, acetaldehyde and reactive oxygen species (ROS), mutate hematopoietic stem cells (HSCs). Importantly, DNA damage is central to the aging process by contributing to stem cell exhaustion, cel…
SARAH A. WILLIAMS-BLANGERO · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · 2024 · $2,011,449 — PROJECT SUMMARY The University of Texas Rio Grande Valley seeks to establish a Diversity Center for Genome Research that will build UTRGV’s genomics research capacity by 1) expanding genomic research capabilities and discoveries in two innovative research projects; and 2) enhancing the size and qual…
Victor G. Davila-Roman · WASHINGTON UNIVERSITY · 2024 · $955,765 — Project Summary/Abstract The foundation for cardiovascular health (CVH) is laid in early life by intergenerational interactions, passed from parent to child, that have long-lasting biological and behavioral consequences. Lifestyle interventions can promote CVH among mothers and their children over t…
Jayhun Lee · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $36,218 — PROJECT SUMMARY/ABSTRACT Despite the hostile environment of the bloodstream where the host immune system is highly active, schistosomes, parasitic flatworms that cause schistosomiasis that affects over 200 million individuals globally, have a remarkable ability to thrive inside the vasculature for o…
KELLIE L. K. TAMASHIRO · JOHNS HOPKINS UNIVERSITY · 2024 · $96,351 — Obesity continues to rise worldwide. Maternal obesity and consumption of high calorie diets continue to be public health concerns. The intrauterine and early postnatal environment provides support that is critical to the proper development and health of offspring. Maternal high fat (HF) diet consump…
Andres J Garcia · GEORGIA INSTITUTE OF TECHNOLOGY · 2024 · $82,702 — PROJECT SUMMARY Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing β-cells of the pancreas are destroyed. T1D affects 3 million children and adults in the US with healthcare costs exceeding $15 billion. Standard therapy with exogenous insulin is burdensome, associated wit…
John Michael Stafford · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $83,238 — Obesity impairs glucose and lipid metabolism and increases the risk of coronary heart disease (CHD). Women with obesity have ~1/2 the risk of CHD as obese men. The risk of CHD goes up with menopause, but by mechanisms distinct from obese men. The protection conferred by estrogen signaling in females…
Samuel Klein · WASHINGTON UNIVERSITY · 2024 · $59,881 — Obesity is associated with an increased risk of serious metabolic abnormalities, such as type 2 diabetes, insulin resistance, and nonalcoholic fatty liver disease (NAFLD). Data obtained from studies conducted in humans and rodents have suggested that “metabolic inflexibility” is critically involved …
Masayuki Nigo · METHODIST HOSPITAL RESEARCH INSTITUTE · 2024 · $470,454 — Abstract: (30 lines) Vancomycin is one of the most commonly used antimicrobial drugs in inpatient settings. National guidelines recommend Bayesian models to monitor the therapeutic drug concentration of vancomycin, especially for methicillin-resistant Staphylococcus aureus (MRSA), to minimize drug t…
Rajan P. Kulkarni · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $705,441 — Immune related adverse events (irAEs) secondary to checkpoint blockade inhibition (CBI) or other immune modulatory therapy for cancer, including head and neck cancers, are a significant problem given the increasing use of CBI and other immunomodulatory agents. It is therefore of critical importance …
Daniel C Link · WASHINGTON UNIVERSITY · 2024 · $2,109,864 — ABSTRACT The Washington University SPORE in Leukemia is a highly dynamic translational cancer research program that focuses specifically on leukemias and myelodysplastic syndromes (MDS). We have assembled an outstanding group of investigators with complementary expertise in basic and clinical leukem…
Abigail Benkert · DUKE UNIVERSITY · 2024 · $83,392 — Project Summary/Abstract Disruption of mitochondrial oxidative phosphorylation (OXPHOS) is associated with the development of biochemical alterations that typically affect tissues with a high energy demand, particularly skeletal and cardiac muscle. An inherited autosomal recessive skeletal myopathy …
Jagpreet Chhatwal · BAYLOR COLLEGE OF MEDICINE · 2024 · $433,960 — The Translational Research Center (TRC) includes a diverse team of clinical and translational researchers with a strong track record of working together to reduce hepatocellular cancer (HCC). The TRC uses data from a unique group of patients with cirrhosis who are being recruited from eight differen…
Chanita A. Hughes-Halbert · UNIVERSITY OF FLORIDA · 2024 · $1,002,053 — SUMMARY – OVERALL COMPONENT The Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity is proposed by the University of Florida (UF), Florida A&M University (FAMU) and the University of Southern California-Norris Comprehensive Cancer Center (USC-NCCC) to eliminate cancer he…
Effie W Petersdorf · FRED HUTCHINSON CANCER CENTER · 2024 · $421,457 — Project Summary The HLA system encoded on chr6p defines the hematopoietic-cell transplantation barrier. Complete and precise HLA allele matching of the transplant donor and patient is performed to mitigate the risks of graft rejection and graft-versus-host disease. These efforts have lowered transpl…
Gina Lynn Razidlo · MAYO CLINIC ROCHESTER · 2024 · $350,743 — Metastasis is the primary cause of cancer death, yet therapeutic strategies to inhibit metastatic invasion do not exist. The long-term goal of our research program is to define the molecular mechanisms driving metastatic invasion, with the goal of identifying novel therapeutic targets and strategies…
Joshua Alfaro · PHARMAIN CORPORATION · 2024 · $995,099 — Osteosarcoma (OSA) is the most common primary malignancy of bone in children and adolescents, accounting for approximately 5% of all childhood tumors (www.cancer.gov). Osteosarcoma occurs primarily in the long bones of the limbs, including most commonly the femur, tibia, and humerus1. The current st…