Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Song Li · UNIVERSITY OF ILLINOIS AT CHICAGO · 2020 · $680,572 — The amplification of Estrogen, Progesterone and Human Epidermal Growth Factor receptors (i.e. ER, PR and HER2) serve as prognostic markers in breast cancer. The prognosis of ER+ breast cancer is relatively better due to availability of several drugs that essentially block ER-signaling. However, HER2…
William H. Peranteau · CHILDREN'S HOSP OF PHILADELPHIA · 2020 · $760,313 — PROJECT SUMMARY Metabolic liver diseases are the second most common indication for a pediatric liver transplant. Hereditary tyrosinemia type I (HT1) is a metabolic liver disease that results from FAH gene mutations causing a deficiency in fumarylacetoacetate hydrolase (FAH), the last enzyme in the t…
Michael Dennis Raleigh · WASHINGTON UNIVERSITY · 2020 · $180,011 — PROJECT SUMMARY. The goal of this CEBRA is to integrate cutting-edge concepts from nanotechnology, immunology, and addiction to develop nanovaccines to treat heroin and prescription opioid abuse and prevent fatal overdose. Opioid abuse is a major national emergency in the US with an enormous cost in…
Elena Aikawa · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $661,115 — Project Summary This research project will test the hypothesis that, in the diabetic milieu, S100A9 induces the calcification potential of macrophage-derived extracellular vesicles (EV), precursors of microcalcifications, contributing to the biomechanical instability of the vulnerable atheroscleroti…
Teri Wang Odom · NORTHWESTERN UNIVERSITY · 2020 · $198,306 — PROJECT SUMMARY This proposal aims to develop live-cell, multi-channel imaging tools that can visualize—continuously, and in real time—nanoparticle interactions with cellular components. We will focus on several different time windows, where early time periods will monitor nanoparticle-cell membran…
John B Barnett · EXESALIBERO, INC. · 2020 · $1,103,697 — We are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and joints. Inflammatory arthritis disables thousands of people each year. It occurs in children and adults, after trauma and infections but most cases are idiopathic.…
Gary Liu · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2020 · $64,926 — PROJECT SUMMARY/ABSTRACT Vascular injury and disease during diabetes lead to end-organ dysfunction (kidney failure, blindness, amputation) and cardiovascular disease that profoundly reduces patient quality of life and life expectancy. The proposed work seeks to develop new therapeutics to prevent an…
Ariana Kathryn von Lersner · VANDERBILT UNIVERSITY · 2020 · $30,238 — PROJECT SUMMARY Extracellular vesicles (EVs) are a heterogenous group of lipid bilayer enclosed particles secreted from cells and are found in most, if not all, biological fluids. The term EV encompasses a wide range of vesicle classes, including exosomes (50-150 nm) and microvesicles (150 nm - 100…
Joshua A Kritzer · TUFTS UNIVERSITY MEDFORD · 2020 · $38,000 — Cell Penetration Profiling for Biotherapeutics Biotechnology promises the ability to control biology and disease with laser-like precision. Hundreds of peptides, proteins and nucleic acids are being developed as diagnostics and therapies, but nearly all of these have poor cell penetration and unpred…
Marco E Zamora · DREXEL UNIVERSITY · 2020 · $45,520 — Proposal Summary/Abstract Acute respiratory distress syndrome (ARDS) is an acute inflammation of the lungs. It represents 10% of all intensive care unit (ICU) admissions in the United States. Despite decades of research and numerous large clinical trials, there are few treatments for ARDS. This lack…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2020 · $714,651 — PROJECT SUMMARY - Research Project 3 Members of the filovirus genera Ebolavirus and Marburgvirus are HHS Tier 1 Category A priority pathogens that cause severe and often fatal hemorrhagic fever (HF) in humans and nonhuman primates (NHPs). There are presently no approved therapeutics for ebolavirus o…
DONALD R GERECKE · RBHS-SCHOOL OF PUBLIC HEALTH · 2020 · $846,767 — Research Project 1. Vesicant-induced Skin Injury Key personnel: Donald Gerecke, Ph.D., Associate Professor, Rutgers University School of Pharmacy Jeffrey D. Laskin, Ph.D., Professor, Rutgers University School of Public Health Project Summary/Abstract Sulfur mustard (bis-2-chloroethyl sulfide, SM) an…
Bruce Shapiro · DIVISION OF BASIC SCIENCES - NCI · 2020 · $1,074,314 — Recently we developed a new type of RNA nanostructure that forms a truncated tetrahedron in collaboration with Luc Jaeger, UC Santa Barbara. The structure was built from our hexameric ring where 4 sides of the tetrahedral structure each contain the hexmeric ring, but each ring contains 3 H-shaped cr…
Xiang Zhang · UNIVERSITY OF LOUISVILLE · 2020 · $459,749 — Abstract: The primary function of Omics Core is to provide members of the ULARC with the expertise, resources and facilities needed for metabolomic, proteomic and bioinformatic analyses of biological samples collected to study liver injury, nutrition, gut:liver interactions, and liver:environment…
Fekadu Kassie · UNIVERSITY OF MINNESOTA · 2020 · $352,275 — PROJECT SUMMARY Lung cancer is the leading cause of cancer-related death in the United States. About 90% of lung cancer cases are associated with genetic/epigenetic changes induced by tobacco smoke (TS). Although all types of lung cells could be affected by TS, the effect on stem cells is particular…
CYRUS R SAFINYA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · 2020 · $295,627 — Project Summary/Abstract The current level of research activity involving gene therapy with either synthetic vectors (carriers) or engineered viruses is unprecedented. Liposomes are the most widely studied nonviral carriers worldwide for nucleic acid (NA) and drug delivery applications. Cationic lip…
MICHAEL P CZECH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2020 · $582,900 — Abstract The overarching long term goal of our laboratory is to understand and exploit how adipose tissues exert powerful control over whole body glucose tolerance and insulin sensitivity. Small amounts of mouse brown (BAT) or human “Beige” adipocytes transplanted into recipient mice can improve glu…
GEORGE K. GITTES · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $374,150 — PROJECT SUMMARY AND RELEVANCE An ideal solution to the treatment or cure of diabetes mellitus would be the formation of new functioning β-cells from the patient’s own tissues, thereby avoiding the need for transplant immunosuppression. Abundant recent data has suggested that α-cells are a likely sou…
Steven Michael Romanelli · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $36,743 — PROJECT SUMMARY The prevalence of obesity has reached pandemic levels with nearly 2 billion people worldwide considered overweight and one-third of that obese. Obesity is associated with an increased risk for type II diabetes, heart disease, and certain types of cancer which severely debilitates qua…
THOMAS Elliott VAN DYKE · ADA FORSYTH INSTITUTE, INC. · 2020 · $463,125 — Project Summary Uncontrolled inflammation is a major impediment to tissue engineering, regeneration and reconstruction of both diseased and injured tissues resulting in further tissue injury, tissue scarring and fibrosis. Stem cell activity is disrupted by persistent signals promoting inflammation, …