Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Emre H. Brookes · UNIVERSITY OF MONTANA · 2020 · $293,074 — Project Summary/Abstract We propose to continue development and support for the UltraScan-III (US3) software suite and develop new code and methods to address challenging biomedical research questions that can be solved with the latest instruments available for analytical ultracentrifugation and at …
Admire Dube · STELLENBOSCH UNIVERSITY · 2020 · $345,569 — SUMMARY Tuberculosis remains a major global public health threat. Although relatively effective drug regimens are available, treatment failure remains a major roadblock to tuberculosis control. This is in part due to a high incidence of drug-resistant Mycobacterium tuberculosis (Mtb) strains, as wel…
Ta Yuan CHANG · DARTMOUTH COLLEGE · 2020 · $408,373 — ABSTRACT of the administrative supplement proposal for the parent grant “Alleviating lysosomal lipid defects in ADRD by blocking cholesterol storage” The long-term goal of this laboratory is to produce cholesterol metabolism-based therapeutics to treat AD and ADRDs. Vascular dementia (VaD), an ADRD,…
James Dahlman · GEORGIA INSTITUTE OF TECHNOLOGY · 2020 · $748,942 — Summary. Hemoglobinopathies such as β-thalassemia and sickle cell disease are genetic disorders caused by mutations in the HBB gene that codes for the β-globin component of hemoglobin. Currently, the only gene therapy available for these prevalent hereditary diseases is based on transplantation of g…
Weiping Qin · BRONX VETERANS MEDICAL RESEARCH FDN · 2020 · $359,365 — Spinal cord injury (SCI) is a serious medical problem that causes loss of sensory, motor and autonomic function due to the damage of central nerve cells. There are no fully restorative therapies for SCI so far, but there is one FDA approved agent methylprednisolone (MP) that is being used clinically…
Marco Brotto · UNIVERSITY OF SOUTH FLORIDA · 2020 · $409,106 — Project Summary Diabetes is a leading cause of death in the US and worldwide with deleterious consequences to the musculoskeletal system. Regardless of glycemic control, diabetes in skeletal muscle manifests with altered metabolism leading to progressive skeletal muscle loss, functional decline, fas…
Maria Lambros · DORICPHARMA LLC · 2020 · $299,559 — PROJECT SUMMARY/ABSTRACT Pancreatic cancer continues to be a devastating disease with less than 10% 5-year survival. Pancreatic cancer is aggressive and there are no good tools for early detection. By the time of diagnosis, the tumor is often surgically unresectable. At this stage, patients are ofte…
Xiaowei Dong · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · 2020 · $361,504 — Project Summary/Abstract Bioavailability enhancement technologies for insoluble drugs represent incremental progress, but no breakthrough oral drug technologies have been identified in the past three decades. Lipid-based drug delivery systems (LBDDS) are considered as a well-established, very import…
Forrest M Kievit · PROTRANSIT NANOTHERAPY, LLC · 2020 · $259,938 — ABSTRACT Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide and comes with a significant economic burden associated with emergency room visits and hospitalizations. Oxidative stress- mediated secondary injury post-TBI is a considerable risk factor for mortali…
Jay Reddy · UNIVERSITY OF NEBRASKA LINCOLN · 2020 · $183,198 — PROJECT SUMMARY/ABSTRACT An estimated 33% of American adults (85.6 million) have some form of cardiovascular disease, with a projected incidence of 43.9% by 2030. Despite heart disease's status as the leading cause of death in humans, there remains a significant gap in our knowledge of its pathogene…
William Olaf Hancock · PENNSYLVANIA STATE UNIVERSITY, THE · 2020 · $318,780 — PROJECT SUMMARY Intracellular cargo transport along microtubules is driven by kinesin and dynein motors that work antagonistically to precisely target cargo to specific cellular locations. Although the mechanisms underlying bidirectional transport have received considerable attention, a number of v…
Kerry S Campbell · THOMAS JEFFERSON UNIVERSITY · 2020 · $528,500 — Project Summary NK cells are capable of killing virus-infected and cancer cells and, therefore, play an important role in innate host defense. Unlike cytotoxic T lymphocytes (CTL), whose cytolytic activity is induced by productive TCR engagement with cognate pMHC ligands, activation of NK cells is r…
WILLIAM M ATKINS · UNIVERSITY OF WASHINGTON · 2020 · $299,338 — Project Summary P-glycoprotein (P-gp) is an ATP-dependent efflux transporter that plays a critical role in drug and xenobiotic distribution, drug-drug interactions, and drug-nutrient interactions. Efforts to modulate P-gp activity to control cellular drug resistance or to modulate the action of exis…
YUQING Eugene CHEN · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $706,887 — ABSTRACT Reverse cholesterol transport (RCT) is an important protective mechanism against atherosclerosis, in which plasma high-density lipoprotein cholesterol (HDL-c) interacts with macrophages in arterial wall and shuttles excess of cholesterol back to the liver. In macrophages, the cholesterol ef…
WILLIAM E. CARSON · OHIO STATE UNIVERSITY · 2020 · $506,986 — PROJECT SUMMARY RNA nanotechnology has progressed rapidly during the past several years. This nanotechnology includes the integration of multiple functional modules into one nanoparticle, of which the scaffolds, ligands, therapeutics, and regulators can be composed mainly or exclusively of RNA. We …
STACY W BLAIN · CONCARLO HOLDINGS, LLC · 2020 · $320,217 — Project Summary/Abstract The goal of this SBIR is to develop a novel drug, IpY, to improve advanced ER/PR+, Her2- breast cancer outcomes. Almost 250,000 US women will be diagnosed this year, and over 40,000 will die, suggesting that despite advances in treatments, breast cancer remains a significant…
ROBERT J LINHARDT · RENSSELAER POLYTECHNIC INSTITUTE · 2020 · $343,946 — Summary Title: Biacore T200 Surface Plasmon Resonance Spectroscopy Surface plasmon resonance (SPR) spectroscopy is a powerful instrument to measure biomolecular interactions in real-time and a label free environment. SPR has been applied to characterize the binding events with samples ranging from p…
Dana Ashley Hill · CHILDREN'S RESEARCH INSTITUTE · 2020 · $407,577 — DESCRIPTION (provided by applicant): Studies of inherited cancer syndromes have provided unique opportunities to uncover and explain important cellular pathways with broad relevance to both sporadic cancers and human development. This proposal studies the cancer predisposition syndrome original…
Aleksandra Elzbieta Sikora · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2020 · $252,429 — ABSTRACT Neisseria gonorrhoeae (Ng) is a human-specific pathogen and the etiological agent of gonorrhea, a sexually transmitted infection with a significant global health burden of ~78 million new cases annually. While often asymptomatic, untreated gonorrhea can lead to pelvic inflammatory disease, …
Hui-Kuan Lin · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2020 · $34,569 — The major goals of the newly formed Signaling and Biotechnology (SBT) Program are to understand the mechanisms underlying cancer pathogenesis and resistance to therapy and to use this knowledge to develop new technologies leading to more effective strategies for improved detection and treatment of c…