Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Daniel F. Hoft · SAINT LOUIS UNIVERSITY · 2021 · $502,177 — Saint Louis University (SLU) seeks to expand its service to the Vaccine and Treatment Evaluation Unit (VTEU) network providing resources and expertise to help the network achieve its objectives of evaluating vaccines, preventive biologics, therapeutics and diagnostics for infectious diseases. Dr. Da…
ASHOK K CHOPRA · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $159,634 — This is a third competitive renewal of our very successful Biodefense Training Program (BTP) for predoctoral students; first funded in 2004, prior to the building of the Galveston National Laboratory (GNL) in 2008. Since then, there has been an explosive growth of research at UTMB on biodefense-rela…
Daniel F. Hoft · SAINT LOUIS UNIVERSITY · 2021 · $305,489 — Saint Louis University (SLU) seeks to expand its service to the Vaccine and Treatment Evaluation Unit (VTEU) network providing resources and expertise to help the network achieve its objectives of evaluating vaccines, preventive biologics, therapeutics and diagnostics for infectious diseases. Dr. Da…
John Beutler · DIVISION OF BASIC SCIENCES - NCI · 2021 · $589,144 — We established MTAs with three of the four NIGMS-funded Chemical Methodologies & Library Developments (CMLD) (Boston University, University of Kansas, and University of Pittsburgh). These three centers alone have provided over 15,000 samples of known structure. Each CMLD has a distinct approach to l…
Daniel F. Hoft · SAINT LOUIS UNIVERSITY · 2020 · $1,627,722 — Saint Louis University (SLU) seeks to expand its service to the Vaccine and Treatment Evaluation Unit (VTEU) network providing resources and expertise to help the network achieve its objectives of evaluating vaccines, preventive biologics, therapeutics and diagnostics for infectious diseases. Dr. Da…
Mark A Jutila · MONTANA STATE UNIVERSITY - BOZEMAN · 2020 · $180,000 — Brucellosis is a zoonotic infection caused by Brucella species. Two species, B. abortus and B. melitensis, are select agents and considered potential bioweapons, and there are no approved vaccines for use in humans. Approved vaccines do exist for livestock; however, they are only 60-70% effective, a…
ASHOK K CHOPRA · UNIVERSITY OF TEXAS MED BR GALVESTON · 2020 · $157,902 — This is a third competitive renewal of our very successful Biodefense Training Program (BTP) for predoctoral students; first funded in 2004, prior to the building of the Galveston National Laboratory (GNL) in 2008. Since then, there has been an explosive growth of research at UTMB on biodefense-rela…
John Beutler · DIVISION OF BASIC SCIENCES - NCI · 2020 · $687,723 — We established MTAs with three of the four NIGMS-funded Chemical Methodologies & Library Developments (CMLD) (Boston University, University of Kansas, and University of Pittsburgh). These three centers alone have provided over 15,000 samples of known structure. Each CMLD has a distinct approach to l…
Daniel F. Hoft · SAINT LOUIS UNIVERSITY · 2020 · $606,000 — Saint Louis University (SLU) seeks to expand its service to the Vaccine and Treatment Evaluation Unit (VTEU) network providing resources and expertise to help the network achieve its objectives of evaluating vaccines, preventive biologics, therapeutics and diagnostics for infectious diseases. Dr. Da…
Daniel F. Hoft · SAINT LOUIS UNIVERSITY · 2020 · $11,154,495 — Saint Louis University (SLU) seeks to expand its service to the Vaccine and Treatment Evaluation Unit (VTEU) network providing resources and expertise to help the network achieve its objectives of evaluating vaccines, preventive biologics, therapeutics and diagnostics for infectious diseases. Dr. Da…
Mark A Jutila · MONTANA STATE UNIVERSITY - BOZEMAN · 2019 · $180,000 — Brucellosis is a zoonotic infection caused by Brucella species. Two species, B. abortus and B. melitensis, are select agents and considered potential bioweapons, and there are no approved vaccines for use in humans. Approved vaccines do exist for livestock; however, they are only 60-70% effective, a…
ASHOK K CHOPRA · UNIVERSITY OF TEXAS MED BR GALVESTON · 2019 · $161,477 — This is a third competitive renewal of our very successful Biodefense Training Program (BTP) for predoctoral students; first funded in 2004, prior to the building of the Galveston National Laboratory (GNL) in 2008. Since then, there has been an explosive growth of research at UTMB on biodefense-rela…
Karl E Klose · UNIVERSITY OF TEXAS SAN ANTONIO · 2019 · $223,250 — Francisella tularensis (Ft), Yersinia pestis (Yp), and Bacillus anthracis (Ba) are considered Category A bioweapons due to ease of transmission, low infectious dose and high mortality associated with pneumonic forms of disease, and the fact that all have been intensively studied and developed in bio…
John Beutler · DIVISION OF BASIC SCIENCES - NCI · 2019 · $630,232 — We established MTAs with three of the four NIGMS-funded Chemical Methodologies & Library Developments (CMLD) (Boston University, University of Kansas, and University of Pittsburgh). These three centers alone have provided over 15,000 samples of known structure. Each CMLD has a distinct approach to l…
Jose Alfonso Rodriguez · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2019 · $234,000 — PROJECT SUMMARY New World Hemorrhagic Fever (NWHF) mammarenaviruses are category A pathogens that pose a grave threat to humans due their high infectivity, mortality between 15-30% when untreated, and our lack of therapeutic options. A subgroup of NWHF mammarenaviruses include the clade B pathogens …
Slobodan Paessler · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $626,423 — PROJECT ABSTRACT/SUMMARY The viruses belonging to the family Arenaviridae contain several causative agents of hemorrhagic fever in humans. For instance, Lassa virus causes Lassa fever, which is a major public health threat in endemic regions of West Africa. Junin virus, Machupo virus, Guanarito viru…
Daniel S Chertow · CLINICAL CENTER · 2024 — Project 1: We previously developed a NHP ICU model in healthy (uninfected) NHPs. We have extended this model to included supportive care of animals infected with E.coli or K. pneumoniae. Among K. pneumoniae infected animals, we have completed a bacterial dose-response study. The manuscript is has b…
Alexander Bukreyev · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $215,675
Thomas William Geisbert · UNIVERSITY OF WASHINGTON · 2024 · $5,867,641 — PROJECT SUMMARY – CORE D: ANIMAL MODELS AND VACCINE EVALUATION Among viruses that cause disease in humans viral zoonoses within the family Paramyxoviridae and order Bunyavirales contain pathogens that cause significant lethality. Importantly, within the Paramyxovirdae the zoonotic henipavirus Hendra…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $4,640,498 — PROJECT SUMMARY/ABSTRACT – Core E (Animal Model Development and Preclinical Evaluation) Among viruses that cause disease in humans, viral zoonoses within the family Paramyxoviridae and order Bunyavirales contain pathogens that cause significant lethality. Importantly, the Arenaviridae and Nairovirid…