Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Juergen A Richt · KANSAS STATE UNIVERSITY · 2024 · $2,256,646 — Overall Project Summary: This COBRE application will form a unique research center on Emerging and Zoonotic Infectious Diseases (EZID). Four primary research projects bridge areas of excellence in the Infectious Diseases programs at Kansas State University (KSU) within the Colleges of Arts and Scien…
Kristian Graugaard Andersen · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $642,549 — Project Summary - Project 2 The objective of Project 2 is to investigate the complex interplay of virus genetics and host immunity in determining epidemiology and outcome of infection with Lassa virus, Ebola virus, and SARS-CoV-2. Our central hypothesis is that both host and virus factors play key r…
Christopher F Basler · WASHINGTON UNIVERSITY · 2024 · $414,434 — RP02 Project Summary/Abstract for Contributions of Ebola and Marburg virus VP30 and VP24 proteins to viral RNA synthesis, assembly and egress Marburg virus (MARV) and Ebola virus (EBOV) are deadly emerging viruses of the filovirus family. Major gaps remain in our understanding as to how filoviral-fi…
Neal Mathew Alto · UT SOUTHWESTERN MEDICAL CENTER · 2023 · $593,045 — PROJECT SUMMARY We are requesting funds to purchase a Zeiss LSM 980 Airyscan 2 confocal microscope for the Microbiology Live Cell Imaging Facility at UTSW Medical Center in Dallas, TX. The system will be dedicated to live cell imaging of Biosafety Level 2 (BSL2) pathogens, experiments that cannot be…
JAMES E CASSAT · VANDERBILT UNIVERSITY MEDICAL CENTER · 2023 · $857,209 — PROJECT SUMMARY / ABSTRACT Funds are requested to purchase a Nikon A1R Multiphoton (MP) Imaging System, to be integrated into the Vanderbilt Cell Imaging Shared Resource (CISR). Vanderbilt has a history of excellence in biomedical imaging, with outstanding facilities for human and live animal imagin…
CHRISTOPHER C BRODER · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2023 · $5,631,841 — Project Summary (OVERALL) The pathogenic henipaviruses (Nipah and Hendra) are distinguished among the paramyxoviruses by virtue of their uniquely broad tropism and impressive lethality. These viruses can infect animals across 6 orders of mammals, causing an often fatal disease in 11 species includin…
Thierry Diagana · UNIVERSITY OF TEXAS MED BR GALVESTON · 2023 · $18,849,015 — OVERALL – ABSTRACT Pandemic prevention and preparedness is a major scientific and societal priority that requires sustained and forward looking investments across governmental, non-governmental, academic and private sectors to develop an arsenal of countermeasures against the existential threat of v…
Lijun Rong · UNIVERSITY OF ILLINOIS AT CHICAGO · 2023 · $780,190 — Summary Ebola virus disease (EVD) is caused by an infection with a group of viruses within the genus Ebolavirus. There are at least five species of Ebolavirus, Ebola virus (Zaire, EBOV), Ebola Sudan (SUDV), Bundibugyo virus (BDBV), Reston virus and Tai Forest virus (TAFV). Infections with these viru…
Juergen A Richt · KANSAS STATE UNIVERSITY · 2023 · $2,260,087 — Overall Project Summary: This COBRE application will form a unique research center on Emerging and Zoonotic Infectious Diseases (EZID). Four primary research projects bridge areas of excellence in the Infectious Diseases programs at Kansas State University (KSU) within the Colleges of Arts and Scien…
Kristian Graugaard Andersen · SCRIPPS RESEARCH INSTITUTE, THE · 2023 · $642,550 — Project Summary - Project 2 The objective of Project 2 is to investigate the complex interplay of virus genetics and host immunity in determining epidemiology and outcome of infection with Lassa virus, Ebola virus, and SARS-CoV-2. Our central hypothesis is that both host and virus factors play key r…
F David Horgen · UNIVERSITY OF HAWAII AT MANOA · 2023 · $243,885 — ALTERATIONS AND RENOVATIONS SUMMARY Building on prior successes, partner institution Hawaii Pacific University (HPU) requests funds for renovations that will support the goals and objectives of the proposed INBRE V renewal. Prior INBRE grants have supported and inspired the development of the biomed…
Christopher F Basler · WASHINGTON UNIVERSITY · 2023 · $436,375 — RP02 Project Summary/Abstract for Contributions of Ebola and Marburg virus VP30 and VP24 proteins to viral RNA synthesis, assembly and egress Marburg virus (MARV) and Ebola virus (EBOV) are deadly emerging viruses of the filovirus family. Major gaps remain in our understanding as to how filoviral-fi…
RONALD B CORLEY · BOSTON UNIVERSITY MEDICAL CAMPUS · 2023 · $738,644 — Administrative Core Summary The NEIDL Administrative Core provides the leadership, organizational structure, and direction of an established management plan that sustains the resources and infrastructure of the NEIDL at the highest level. This enables us to meet our mandate as a member of NIAID’s na…
Kevin Michael Tuohey · BOSTON UNIVERSITY MEDICAL CAMPUS · 2023 · $1,926,969 — Core 3: Environmental Health and Biosafety Regulations and Requirements Abstract The Environmental Health and Biosafety Regulations and Requirements (EHBRR) Core includes three components: Environmental Health and Safety, Emergency Management, and Occupational Medicine. The Core is integrated with c…
Thomas William Geisbert · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2023 · $2,538,747 — Abstract Among viruses that cause disease in humans the henipaviruses, Hendra virus (HeV) and Nipah virus (NiV), stand out for their impressive lethality. These viruses are among the most deadly human pathogens known to man with case fatality rates averaging about 75% for NiV. Significantly, there i…
Jason Douglas Salter · OYAGEN, INC. · 2023 · $299,000 — PROJECT SUMMARY This R43 proposal answers the call of the RFA PA-22-176 for assay development and chemical probe screening by addressing the unmet need for development of antiviral treatments for Ebola patients through an innovative high-content small molecule screen for antagonists of the Ebola VP4…
Cheng Huang · UNIVERSITY OF TEXAS MED BR GALVESTON · 2023 · $200,000 — PROJECT SUMMARY/ABSTRACT Several mammalian arenaviruses cause severe and fatal zoonotic diseases in humans, for which vaccines and treatments are very limited. Lassa virus (LASV) is the causative agent for Lassa fever (LF) that is currently endemic in Western Africa. Despite its importance to public…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2023 · $1,159,045 — PROJECT SUMMARY/ABSTRACT Nipah virus (NiV) causes febrile encephalitis and severe respiratory disease in humans with fatality rates as high as 100% in some outbreaks (average ~ 75% for outbreaks over the last decade). There are currently no licensed vaccines or therapies for combating NiV disease. N…
Gregg A Dean · COLORADO STATE UNIVERSITY · 2023 · $465,165 — Contact PD/PI: Dean, Gregg A. Infectious Disease Research and Response Training Program (IDRRTP) The Infectious Disease Research and Response Network (IDRRN) was established in 2016 and has been recognized as a Program of Research and Scholarly Excellence (PRSE) at Colorado State University. The IDR…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2023 · $7,043,167 — OVERALL - Project Summary/Abstract Among viruses that cause disease in humans the filoviruses, Ebolavirus and Marburgvirus, stand out for their impressive lethality. These viruses are the most deadly human pathogens known to man with reported case fatality rates of up to 90%. The recent unprecedente…