Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Parizad Torabi-Parizi · CLINICAL CENTER · 2021 — Coronavirus disease 19 (COVID-19) is a rapidly growing health threat in the United States with a fatality rate ten times greater than with seasonal influenza. The virus is highly transmissible and has rapidly infected large numbers of people in China, in several European countries, and now in the US…
JILL E HUTCHCROFT · PURDUE UNIVERSITY · 2021 · $82,914 — Flow Cytometry Shared Resource (FC-SR) Project Summary The Purdue Flow Cytometry Shared Resource (FC-SR) provides advanced cell and particle analysis, cell sorting and single cell genomic capabilities to members of the Purdue University Center for Cancer Research (PCCR). The FC-SR has made major i…
Alexander Bukreyev · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $80,593 — ADMINISTRATIVE CORE (Core A): PROJECT SUMMARY/ABSTRACT The Administrative Core is responsible for the strategic planning, overall management, and coordination of the Program Project (P01) “Molecular Mechanisms of the Dysregulated Immune Response to Ebola Virus”. It provides governance, financial ove…
Ricardo Rajsbaum · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $395,000 — The most recent outbreak of Ebola virus (EBOV) in West Africa reached alarming numbers of infections and deaths, prompting extensive efforts to develop antiviral strategies; however, none have thus far been approved for use in humans. The development of antiviral drugs is mostly based on designing c…
Lijun Rong · CHICAGO BIOSOLUTIONS, INC. · 2021 · $982,388 — Ebola (EBOV) and Marburg (MARV) viruses belong to the Filoviridae family and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction after an incubation period of 4-14 days. Due to safety concerns, these viruses are designated as biosafety level 4 agents. Currently, there i…
DAVID Branch MOODY · BRIGHAM AND WOMEN'S HOSPITAL · 2021 · $223,260 — The Metabolomics Core (B) is comprised of a Biosafety Level 3 suite for handling infectious samples, massively parallel detection of mycobacterial metabolites using Time of Flight mass spectrometry (Agilent Accurate Mass ToF 6230), specialized resources for identifying known mycobacterial compound…
Alexander Bukreyev · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $215,591 — BSL-4 CORE (Core B): PROJECT SUMMARY/ABSTRACT The pathogenesis of Ebola virus (EBOV) disease is characterized by a dysregulated immune response that includes the suppression of the innate immune system leading to “immune paralysis” and paradoxically activation of inflammatory pathways characteristic…
Juergen A Richt · KANSAS STATE UNIVERSITY · 2021 · $2,266,526 — Overall Project Summary: This COBRE application will form a unique research center on Emerging and Zoonotic Infectious Diseases (EZID). Four primary research projects bridge areas of excellence in the Infectious Diseases programs at Kansas State University (KSU) within the Colleges of Arts and Scien…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $1,415,990 — PROJECT SUMMARY/ABSTRACT Nipah virus (NiV) causes febrile encephalitis and severe respiratory disease in humans with fatality rates as high as 100% in some outbreaks (average ~ 75% for outbreaks over the last decade). There are currently no licensed vaccines or therapies for combating NiV disease. N…
Patricia Veronica Aguilar · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $300,959 — Abstract Non-malarial acute undifferentiated febrile illnesses (AUFIs) are significant causes of morbidity and mortality in Latin America, and the incidence of dengue-like illness has increased dramatically in recent years. As in most low-and middle-income countries, only a handful of “dengue” cases…
JOANN M TUFARIELLO · GEORGIA STATE UNIVERSITY · 2021 · $31,000 — Summary This developmental project seeks to develop methods to dramatically boost immunogenicity of virus-like particle (VLP) vaccines. Ebola virus (EBOV) and Marburg virus (MARV) are members of the filovirus family of enveloped, negative-sense RNA viruses that causes outbreaks of severe human disea…
Jae U Jung · CLEVELAND CLINIC LERNER COM-CWRU · 2021 · $604,163 — Project Summary/Abstract Severe fever with thrombocytopenia syndrome virus (SFTSV) listed in the World Health Organization 9 most dangerous pathogens is an emerging Phlebovirus in the Phenuiviridae family. Due to the lack of therapy and vaccine against SFTSV infection, there is a pressing need to u…
ROBERT A DAVEY · PURDUE UNIVERSITY · 2021 · $621,031 — A research team from Purdue University and Texas Biomedical Research Institute is in pursuit of important new approaches to validate the host V-ATPase. The project goal to define antiviral drug leads for diseases caused by Ebola and Marburg filoviruses. Many viral pathogens bind to specific factors …
Christopher F Basler · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $770,311 — Project Summary Filoviruses, which include the ebolaviruses and marburgviruses, are non-segmented, negative-sense RNA viruses (NNSVs) that cause severe human disease. These viruses are of concern as emerging pathogens and as potential bioterrorism threats. Their importance and public health impact a…
Thomas William Geisbert · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2021 · $1,144,444 — Abstract Among viruses that cause disease in humans the henipaviruses, Hendra virus (HeV) and Nipah virus (NiV), stand out for their impressive lethality. These viruses are among the most deadly human pathogens known to man with case fatality rates averaging about 75% for NiV. Significantly, there i…
Ferenc Livak · DIVISION OF BASIC SCIENCES - NCI · 2021 · $1,591,689 — The mission of the CCR LGI Flow Cytometry Core in Building 37 (FC37) is to offer up-to-date instrumentation and technical expertise to CCR investigators to assist cancer research. The core provides full-scale, state-of-the-art flow cytometry services including analytical sample acquisition, data ana…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $2,542,134 — PROJECT SUMMARY/ABSTRACT – BSL-4 Evaluation Core (Core B) Among viruses that cause disease in humans the filoviruses, Ebolavirus and Marburgvirus, stand out for their impressive lethality. These viruses are the most deadly human pathogens known to man with reported case fatality rates of up to 90%. …
Kevin Michael Tuohey · BOSTON UNIVERSITY MEDICAL CAMPUS · 2021 · $1,916,666 — Core 3: Environmental Health and Biosafety Regulations and Requirements Abstract The Environmental Health and Biosafety Regulations and Requirements (EHBRR) Core includes three components: Environmental Health and Safety, Emergency Management, and Occupational Medicine. The Core is integrated with c…
Yi Zeng · UNIVERSITY OF ARIZONA · 2021 · $154,591 — Project Summary / Abstract: Flow Cytometry Shared Resource (FCSR) The goal of the Flow Cytometry Shared Resource (FCSR), which has served investigators of the University of Arizona Cancer Center (UACC) for more than 25 years, is to offer UACC Members efficient and reliable flow cytometric service…
CHRISTOPHER C BRODER · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2021 · $4,765,823 — Project Summary (OVERALL) The pathogenic henipaviruses (Nipah and Hendra) are distinguished among the paramyxoviruses by virtue of their uniquely broad tropism and impressive lethality. These viruses can infect animals across 6 orders of mammals, causing an often fatal disease in 11 species includin…