Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $7,043,167 — OVERALL - Project Summary/Abstract Among viruses that cause disease in humans the filoviruses, Ebolavirus and Marburgvirus, stand out for their impressive lethality. These viruses are the most deadly human pathogens known to man with reported case fatality rates of up to 90%. The recent unprecedente…
JOANN M TUFARIELLO · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $230,538 — Summary This developmental project seeks to develop methods to dramatically boost immunogenicity of virus-like particle (VLP) vaccines. Ebola virus (EBOV) and Marburg virus (MARV) are members of the filovirus family of enveloped, negative-sense RNA viruses that causes outbreaks of severe human disea…
Colleen B Jonsson · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2021 · $3,211,742 — Project Summary The University of Tennessee Health Sciences Center (UTHSC) proposes to upgrade facilities and broaden research services in the existing UTHSC Regional Biocontainment Laboratory (RBL) located in Memphis, TN to support internal and external investigators in basic and translational rese…
KENNETH E PALMER · UNIVERSITY OF LOUISVILLE · 2021 · $3,333,333 — The University of Louisville Regional Biocontainment Laboratory (RBL) is an operational unit of the University’s Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases (CPM). The CPM operates the only Biosafety Level 3 laboratories and animal research facilities available t…
Jay Kenneth Fisher · REDBUD LABS, INC. · 2021 · $291,649 — ABSTRACT We propose to develop a point-of-need system for differential molecular identification of filoviruses from syndromically similar infections. Our goal is to enable rapid, sensitive, and specific identification of quarantinable infections to reduce nosocomial risk and improve outbreak respons…
Gregg A Dean · COLORADO STATE UNIVERSITY · 2021 · $214,464 — Contact PD/PI: Dean, Gregg A. Infectious Disease Research and Response Training Program (IDRRTP) The Infectious Disease Research and Response Network (IDRRN) was established in 2016 and has been recognized as a Program of Research and Scholarly Excellence (PRSE) at Colorado State University. The IDR…
SUZETTE Alise PRIOLA · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $889,806 — Transmissible spongiform encephalopathies (TSEs or prion diseases) are a group of rare neurodegenerative diseases which include sporadic Creutzfeldt-Jakob disease (sCJD) in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) in mule deer and elk. Prion…
BYRON CAUGHEY · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $1,371,020 — 1) Real-time quaking-induced conversion (RT-QuIC) assays detect prion-seeding activity in a variety of human biospecimens, including cerebrospinal fluid and olfactory mucosa swabs. The assay has shown high diagnostic accuracy in patients with prion disorders. Recently, advances in these tests have l…
RONALD B CORLEY · BOSTON UNIVERSITY MEDICAL CAMPUS · 2021 · $1,916,668 — Administrative Core Summary The NEIDL Administrative Core provides the leadership, organizational structure, and direction of an established management plan that sustains the resources and infrastructure of the NEIDL at the highest level. This enables us to meet our mandate as a member of NIAID’s na…
STEPHEN C JAMESON · UNIVERSITY OF MINNESOTA · 2021 · $192,543 — Summary Core B NME Mouse Core Our published studies suggest that mice with more physiological exposure to natural mouse microbes have immune systems that are a better match for the immune system in humans: In contrast to typical “clean” laboratory mice (which are maintained in barrier facilities to …
JORGE C BLANCO · SIGMOVIR BIOSYSTEMS, INC. · 2020 · $476,975 — The SARS-CoV-2 responsible for the Coronavirus disease 2019 (COVID-2019) outbreak represents a major public health threat that urgently requires development of a small animal model that can be used to test medical countermeasures. This supplement proposal is a logical extension of our parent grant, …
Christopher F Basler · GEORGIA STATE UNIVERSITY · 2020 · $779,568 — Project Summary Filoviruses, which include the ebolaviruses and marburgviruses, are non-segmented, negative-sense RNA viruses (NNSVs) that cause severe human disease. These viruses are of concern as emerging pathogens and as potential bioterrorism threats. Their importance and public health impact a…
Gaya K. Amarasinghe · WASHINGTON UNIVERSITY · 2020 · $2,554,916 — Abstract: Project Overview for Structural and Functional Studies of Ebola Virus RNA synthesis Ebolaviruses (EBOVs) are non-segmented negative-strand RNA viruses (NNSVs) and Category A Priority biodefense pathogens that cause frequent lethal hemorrhagic fever, including the devastating and ongoing ou…
Lijun Rong · CHICAGO BIOSOLUTIONS, INC. · 2020 · $961,660 — Ebola (EBOV) and Marburg (MARV) viruses belong to the Filoviridae family and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction after an incubation period of 4-14 days. Due to safety concerns, these viruses are designated as biosafety level 4 agents. Currently, there i…
Parizad Torabi-Parizi · CLINICAL CENTER · 2020 — Coronavirus disease 19 (COVID-19) is a rapidly growing health threat in the United States with a fatality rate ten times greater than with seasonal influenza. The virus is highly transmissible and has rapidly infected large numbers of people in China, in several European countries, and now in the US…
Ferenc Livak · DIVISION OF BASIC SCIENCES - NCI · 2020 · $1,192,401 — The core is equipped with six analytical instruments: a state-of-the-art BD FACSymphony A5 flow cytometer equipped with five lasers and the capacity to identify 27 fluorochromes also equipped with a high throughput sampler (HTS) attachment that accommodates 96-well plates to further increase the cap…
Iyadh Douagi · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $770,735 — In 2020 the project aims to use state of the art instrumentation to support the immediate research needs for COVID19 research in flow cytometry. We are particularly interested in using the CytoFLEX LX Flow Cytometry Analyzer. It is a highly capable flow cytometry analyzer equipped with 6 lasers an…
JILL E HUTCHCROFT · PURDUE UNIVERSITY · 2020 · $82,914 — Flow Cytometry Shared Resource (FC-SR) Project Summary The Purdue Flow Cytometry Shared Resource (FC-SR) provides advanced cell and particle analysis, cell sorting and single cell genomic capabilities to members of the Purdue University Center for Cancer Research (PCCR). The FC-SR has made major i…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2020 · $7,339,433 — OVERALL - Project Summary/Abstract Among viruses that cause disease in humans the filoviruses, Ebolavirus and Marburgvirus, stand out for their impressive lethality. These viruses are the most deadly human pathogens known to man with reported case fatality rates of up to 90%. The recent unprecedente…
CHRISTOPHER C BRODER · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2020 · $4,326,275 — Project Summary (OVERALL) The pathogenic henipaviruses (Nipah and Hendra) are distinguished among the paramyxoviruses by virtue of their uniquely broad tropism and impressive lethality. These viruses can infect animals across 6 orders of mammals, causing an often fatal disease in 11 species includin…