Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Ricardo Rajsbaum · UNIVERSITY OF TEXAS MED BR GALVESTON · 2019 · $395,000 — The most recent outbreak of Ebola virus (EBOV) in West Africa reached alarming numbers of infections and deaths, prompting extensive efforts to develop antiviral strategies; however, none have thus far been approved for use in humans. The development of antiviral drugs is mostly based on designing c…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2019 · $7,043,167 — OVERALL - Project Summary/Abstract Among viruses that cause disease in humans the filoviruses, Ebolavirus and Marburgvirus, stand out for their impressive lethality. These viruses are the most deadly human pathogens known to man with reported case fatality rates of up to 90%. The recent unprecedente…
Gaya K. Amarasinghe · WASHINGTON UNIVERSITY · 2019 · $2,563,154 — Abstract: Project Overview for Structural and Functional Studies of Ebola Virus RNA synthesis Ebolaviruses (EBOVs) are non-segmented negative-strand RNA viruses (NNSVs) and Category A Priority biodefense pathogens that cause frequent lethal hemorrhagic fever, including the devastating and ongoing ou…
Ron L Morales · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 · $1,427,462 — Environmental Health and Biosafety Regulations and Requirements (EH&S): Summary The Environmental Health and Biosafety Regulations and Requirements Core (EH&S) includes three components, Environmental Health and Safety, Emergency Management, and Occupational Medicine. The EH&S Core is integrated wit…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2019 · $2,665,747 — PROJECT SUMMARY/ABSTRACT – BSL-4 Evaluation Core (Core B) Among viruses that cause disease in humans the filoviruses, Ebolavirus and Marburgvirus, stand out for their impressive lethality. These viruses are the most deadly human pathogens known to man with reported case fatality rates of up to 90%. …
ROBERT A DAVEY · PURDUE UNIVERSITY · 2019 · $639,566 — A research team from Purdue University and Texas Biomedical Research Institute is in pursuit of important new approaches to validate the host V-ATPase. The project goal to define antiviral drug leads for diseases caused by Ebola and Marburg filoviruses. Many viral pathogens bind to specific factors …
Lijun Rong · CHICAGO BIOSOLUTIONS, INC. · 2019 · $972,475 — Ebola (EBOV) and Marburg (MARV) viruses belong to the Filoviridae family and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction after an incubation period of 4-14 days. Due to safety concerns, these viruses are designated as biosafety level 4 agents. Currently, there i…
STEPHEN C JAMESON · UNIVERSITY OF MINNESOTA · 2019 · $192,388 — Summary Core B NME Mouse Core Our published studies suggest that mice with more physiological exposure to natural mouse microbes have immune systems that are a better match for the immune system in humans: In contrast to typical “clean” laboratory mice (which are maintained in barrier facilities to …
CHRISTOPHER C BRODER · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2019 · $4,260,825 — Project Summary (OVERALL) The pathogenic henipaviruses (Nipah and Hendra) are distinguished among the paramyxoviruses by virtue of their uniquely broad tropism and impressive lethality. These viruses can infect animals across 6 orders of mammals, causing an often fatal disease in 11 species includin…
Christopher F Basler · GEORGIA STATE UNIVERSITY · 2019 · $779,570 — Project Summary Filoviruses, which include the ebolaviruses and marburgviruses, are non-segmented, negative-sense RNA viruses (NNSVs) that cause severe human disease. These viruses are of concern as emerging pathogens and as potential bioterrorism threats. Their importance and public health impact a…
SUZETTE Alise PRIOLA · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2019 · $1,268,450 — Transmissible spongiform encephalopathies (TSEs or prion diseases) are a group of rare neurodegenerative diseases which include sporadic Creutzfeldt-Jakob disease (sCJD) in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) in mule deer and elk. Prion…
Ferenc Livak · DIVISION OF BASIC SCIENCES - NCI · 2019 · $1,034,245 — The mission of the CCR LGI Flow Cytometry Core in Building 37 (FC37) is to offer up-to-date instrumentation and technical expertise to CCR investigators to assist cancer research. The core provides full-scale, state-of-the-art flow cytometry services including analytical sample acquisition, data ana…
Jordi Ochando · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2019 · $170,390 — ABSTRACT – FLOW CYTOMETRY SHARED RESOURCE Shared Resource Leader: Jordi Ochando, PhD The Tisch Cancer Institute (TCI) Flow Cytometry Shared Resource Facility (FCSRF) provides TCI members access to state-of-the-art technology and expertise for the successful development of scientific research pro…
Jae U Jung · UNIVERSITY OF SOUTHERN CALIFORNIA · 2019 · $617,831 — Project Summary/Abstract Severe fever with thrombocytopenia syndrome virus (SFTSV) listed in the World Health Organization 9 most dangerous pathogens is an emerging Phlebovirus in the Phenuiviridae family. Due to the lack of therapy and vaccine against SFTSV infection, there is a pressing need to u…
CHRISTOPHER C BRODER · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2019 · $193,928 — Project Summary/Abstract The emergence of pathogenic viruses represents continuous infectious disease threats to public health. Among these, the paramyxoviruses, which include many important human and animal pathogens, also include two excellent examples of emerged, zoonotic pathogens of importance:…
Daniel S Chertow · CLINICAL CENTER · 2019 — Project 1: In this study, we will expose pregnant rhesus macaques to ZIKV in the first, second, or third trimesters of their 165-day gestational period. Following exposure, we will investigate fetal brain development and evolution of brain injury using serial fetal brain imaging (MRI and ultrasound)…
Yi Zeng · UNIVERSITY OF ARIZONA · 2019 · $84,504 — Project Summary / Abstract: Flow Cytometry Shared Resource (FCSR) The goal of the Flow Cytometry Shared Resource (FCSR), which has served investigators of the University of Arizona Cancer Center (UACC) for more than 25 years, is to offer UACC Members efficient and reliable flow cytometric service…
Corrie Ntiforo · UNIVERSITY OF TEXAS MED BR GALVESTON · 2019 · $409,937 — The overall goal of this project is to maintain the high containment research resources (infrastructure and facilities) required to conduct research that will facilitate the next generation therapeutics, diagnostics and vaccines for infectious diseases. The Galveston National Laboratory (GNL) at the…
Yi Zeng · UNIVERSITY OF ARIZONA · 2019 · $22,222 — Project Summary / Abstract: Flow Cytometry Shared Resource (FCSR) The goal of the Flow Cytometry Shared Resource (FCSR), which has served investigators of the University of Arizona Cancer Center (UACC) for more than 25 years, is to offer UACC Members efficient and reliable flow cytometric service…
Yi Zeng · UNIVERSITY OF ARIZONA · 2019 · $11,939 — Project Summary / Abstract: Flow Cytometry Shared Resource (FCSR) The goal of the Flow Cytometry Shared Resource (FCSR), which has served investigators of the University of Arizona Cancer Center (UACC) for more than 25 years, is to offer UACC Members efficient and reliable flow cytometric service…