Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
DAVID Branch MOODY · BRIGHAM AND WOMEN'S HOSPITAL · 2019 · $295,736 — The Metabolomics Core (B) is comprised of a Biosafety Level 3 suite for handling infectious samples, massively parallel detection of mycobacterial metabolites using Time of Flight mass spectrometry (Agilent Accurate Mass ToF 6230), specialized resources for identifying known mycobacterial compound…
Thomas William Geisbert · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2019 · $780,615 — Abstract Among viruses that cause disease in humans the henipaviruses, Hendra virus (HeV) and Nipah virus (NiV), stand out for their impressive lethality. These viruses are among the most deadly human pathogens known to man with case fatality rates averaging about 75% for NiV. Significantly, there i…
David Aaron Jacobson · VANDERBILT UNIVERSITY · 2024 · $72,900 — Project Summary Islet glucose-stimulated somatostatin (Sst) secretion is lost in patients with type-2 diabetes (T2D) and in animal models of the disease, which contributes to disrupted glucagon and insulin secretion. It is generally accepted that Sst secretion from -cells occurs in response to elev…
David Aaron Jacobson · VANDERBILT UNIVERSITY · 2024 · $431,638 — Project Summary Islet glucose-stimulated somatostatin (Sst) secretion is lost in patients with type-2 diabetes (T2D) and in animal models of the disease, which contributes to disrupted glucagon and insulin secretion. It is generally accepted that Sst secretion from -cells occurs in response to elev…
Jenna Susan Reed · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $39,995 — Abstract Malaria afflicted 247 million people in 2021, of which over 600,000 died. In the most severe cases, patients can develop organ-specific pathologies related to vascular leak, including cerebral malaria and malaria-associated acute respiratory distress syndrome (MA-ARDS). The mechanisms of pu…
Scott Benjamin Biering · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $162,000 — PROJECT SUMMARY/ABSTRACT Research Project: Dengue virus (DENV) is a medically important pathogen posing a major public health threat. DENV infection can result in potentially fatal cases of severe dengue associated with vascular leak as a result of endothelial dysfunction, but the triggers of these …
Joshua Anthony Keefe · BAYLOR COLLEGE OF MEDICINE · 2024 · $49,244 — PROJECT SUMMARY/ABSTRACT There is a fundamental gap in the understanding of the molecular drivers of postoperative atrial fibrillation (poAF), which is self-limited atrial fibrillation (AF) 2-4 days after surgery. The recurrence rate of AF is eight-fold greater and mortality risk two-fold greater in…
KENNETH R COOKE · JOHNS HOPKINS UNIVERSITY · 2023 · $400,716 — Allogeneic blood and marrow transplantation (allo-BMT) is the only curative therapy for many pediatric patients with malignant and non-malignant disorders. Unfortunately, treatment-related complications remain a major barrier to successful outcomes. A multiple organ dysfunction syndrome (MODS) works…
David Aaron Jacobson · VANDERBILT UNIVERSITY · 2023 · $449,622 — Project Summary Islet glucose-stimulated somatostatin (Sst) secretion is lost in patients with type-2 diabetes (T2D) and in animal models of the disease, which contributes to disrupted glucagon and insulin secretion. It is generally accepted that Sst secretion from -cells occurs in response to elev…
David Aaron Jacobson · VANDERBILT UNIVERSITY · 2023 · $30,368 — Project Summary Islet glucose-stimulated somatostatin (Sst) secretion is lost in patients with type-2 diabetes (T2D) and in animal models of the disease, which contributes to disrupted glucagon and insulin secretion. It is generally accepted that Sst secretion from -cells occurs in response to elev…
Philip Anfinrud · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2023 · $574,654 — As the NIH began loosening requirements for returning to the lab, the pace of our collaborative pressure-jump NMR studies picked up. Three home-built pressure-jump systems are currently operable. During the pandemic, the consoles used to operate the high-field Bruker NMR magnets were upgraded, which…
ROBERT KREITMAN · DIVISION OF BASIC SCIENCES - NCI · 2023 · $1,665,659 — Overview. We focus on targeted therapy for hematologic malignancies, particularly hairy cell leukemia (HCL), and other new therapies for HCL. Moxetumomab pasudotox (Moxe) contains truncated Pseudomonas exotoxin (PE) fused to an anti-CD22 Fv fragment. Previously called HA22 or CAT-8015, it is an affi…
Ashley Loeven · FLORIDA STATE UNIVERSITY · 2023 · $42,193 — ABSTRACT Previous experiments in our lab have shown that a fatty diet reduces olfactory sensory neuronal abundance. Isocaloric feeding in which a fat-fed mouse consumed the same number of calories as a control-fed mouse, but of fatty chow, prevented obesity but did not prevent the neuronal loss. It …
Donald M Bers · UNIVERSITY OF CALIFORNIA AT DAVIS · 2022 · $760,168 — Project Summary Our overall goal is to understand the structural mechanisms for the functional dysregulation of the cardiac ryanodine receptor (RyR2) Ca2+-release channels in the sarcoplasmic reticulum (SR). RyR2 contributes to and is a therapeutic target for treating heart failure (HF) and arrhythm…
Sheng Luan · UNIVERSITY OF CALIFORNIA BERKELEY · 2022 · $66,680 — This equipment supplement application seeks funding for replacement of a broken growth chamber for culturing plant materials used in the parent project. The model plant Arabidopsis must be grown and maintained in a controlled environments. In particular, our plants are routinely transgenic containin…
JANE B TREPEL · DIVISION OF CLINICAL SCIENCES - NCI · 2022 · $1,205,526 — Our major activities in FY2022 were to work with clinical investigators to develop new pharmacodynamic (PD) assays tailored to their clinical trials and to implement these PD assays in the clinical trials we have open in FY2022. Our specific objectives are (1) to determine if a therap…
David Aaron Jacobson · VANDERBILT UNIVERSITY · 2022 · $449,622 — Project Summary Islet glucose-stimulated somatostatin (Sst) secretion is lost in patients with type-2 diabetes (T2D) and in animal models of the disease, which contributes to disrupted glucagon and insulin secretion. It is generally accepted that Sst secretion from -cells occurs in response to elev…
KENNETH R COOKE · JOHNS HOPKINS UNIVERSITY · 2022 · $400,716 — Allogeneic blood and marrow transplantation (allo-BMT) is the only curative therapy for many pediatric patients with malignant and non-malignant disorders. Unfortunately, treatment-related complications remain a major barrier to successful outcomes. A multiple organ dysfunction syndrome (MODS) works…
Ashley Loeven · FLORIDA STATE UNIVERSITY · 2022 · $41,151 — ABSTRACT Previous experiments in our lab have shown that a fatty diet reduces olfactory sensory neuronal abundance. Isocaloric feeding in which a fat-fed mouse consumed the same number of calories as a control-fed mouse, but of fatty chow, prevented obesity but did not prevent the neuronal loss. It …
ROBERT KREITMAN · DIVISION OF BASIC SCIENCES - NCI · 2022 · $1,340,622 — Overview. We focus on targeted therapy for hematologic malignancies, particularly hairy cell leukemia (HCL), and other new therapies for HCL. Moxetumomab pasudotox (Moxe) contains truncated Pseudomonas exotoxin (PE) fused to an anti-CD22 Fv fragment. Previously called HA22 or CAT-8015…