Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Donald M Bers · UNIVERSITY OF CALIFORNIA AT DAVIS · 2021 · $760,168 — Project Summary Our overall goal is to understand the structural mechanisms for the functional dysregulation of the cardiac ryanodine receptor (RyR2) Ca2+-release channels in the sarcoplasmic reticulum (SR). RyR2 contributes to and is a therapeutic target for treating heart failure (HF) and arrhythm…
JANE B TREPEL · DIVISION OF CLINICAL SCIENCES - NCI · 2021 · $1,199,893 — Our major activities in FY2021 were to work with clinical investigators to develop new pharmacodynamic (PD) assays tailored to their clinical trials and to implement these PD assays in the clinical trials we have open in FY2021. Our specific objectives are (1) to determine if a therapy hit its targe…
Daniel Reich · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2021 · $5,061,016 — In Fiscal Year 2021, we have continued to pursue two specific aims: (1) to study the pathophysiology of MS through high-resolution MRI and (2) to study the biology of inflammatory demyelination in a translationally relevant primate model of MS. We have seen significant progress toward accomplishing …
KENNETH R COOKE · JOHNS HOPKINS UNIVERSITY · 2021 · $400,716 — Allogeneic blood and marrow transplantation (allo-BMT) is the only curative therapy for many pediatric patients with malignant and non-malignant disorders. Unfortunately, treatment-related complications remain a major barrier to successful outcomes. A multiple organ dysfunction syndrome (MODS) works…
CRAIG S LEVIN · STANFORD UNIVERSITY · 2021 · $157,700 — Project Summary / Abstract (from parent application) We propose to create and explore a radio-frequency (RF)-penetrable positron emission tomography (PET) system technology that can be inserted into a magnetic resonance imaging (MRI) system for acquiring simultaneous PET/MRI data. Integrated PET/MRI…
JANE B TREPEL · DIVISION OF CLINICAL SCIENCES - NCI · 2020 · $1,097,545 — Our major activities in FY2020 were to work with clinical investigators to develop new pharmacodynamic (PD) assays tailored to their clinical trials and to implement these PD assays in the clinical trials we have open in FY2020. Our specific objectives are (1) to determine if a therapy hit its targe…
KENNETH R COOKE · JOHNS HOPKINS UNIVERSITY · 2020 · $408,895 — Allogeneic blood and marrow transplantation (allo-BMT) is the only curative therapy for many pediatric patients with malignant and non-malignant disorders. Unfortunately, treatment-related complications remain a major barrier to successful outcomes. A multiple organ dysfunction syndrome (MODS) works…
Donald M Bers · UNIVERSITY OF CALIFORNIA AT DAVIS · 2020 · $760,168 — Project Summary Our overall goal is to understand the structural mechanisms for the functional dysregulation of the cardiac ryanodine receptor (RyR2) Ca2+-release channels in the sarcoplasmic reticulum (SR). RyR2 contributes to and is a therapeutic target for treating heart failure (HF) and arrhythm…
ZAYD M KHALIQ · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2019 · $1,793,169 — Our laboratory studies the cellular and subcellular principles of integration and excitability in dopamine-releasing neurons located in the midbrain. A major interest of the lab is identifying functionally unique subpopulations of midbrain dopamine neurons and understanding how these neurons contrib…
Donald M Bers · UNIVERSITY OF CALIFORNIA AT DAVIS · 2019 · $774,418 — Project Summary Our overall goal is to understand the structural mechanisms for the functional dysregulation of the cardiac ryanodine receptor (RyR2) Ca2+-release channels in the sarcoplasmic reticulum (SR). RyR2 contributes to and is a therapeutic target for treating heart failure (HF) and arrhythm…
Bjorn C Knollmann · VANDERBILT UNIVERSITY MEDICAL CENTER · 2019 · $552,322 — DESCRIPTION (provided by applicant): Although atrial fibrillation (AF) is the most prevalent cardiac arrhythmia requiring antiarrhythmic drug therapy, response in an individual patient is highly variable with frequent AF recurrence. The limited success of drug therapy has been attributed in part to …
Ankit Bharat · NORTHWESTERN UNIVERSITY AT CHICAGO · 2019 · $162,086 — DESCRIPTION (provided by applicant): Candidate: Dr. Bharat's academic training, research experience and drive place him in an excellent position for a successful career to become a leading independent investigator. He intends to pursue a career in academic surgery with a strong commitment to b…
Cara Brook · UNIVERSITY OF CHICAGO · 2024 · $91,090 — The wide-reaching impacts of the COVID-19 pandemic highlight the extreme threat posed by the cross-species emergence of zoonotic pathogens. Bats (order: Chiroptera) are the natural reservoir hosts for the majority of the world’s most virulent zoonotic viruses, including Hendra and Nipah henipaviruse…
Olivia Cords · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $41,972 — ABSTRACT Coronavirus Infection Dynamics and Cross-species Transmission in Bats Prevention of future zoonotic disease emergence, including pandemic threats, is only possible with a thorough understanding of infection dynamics in reservoir host populations. The emergence of SARS-CoV, MERS, and SARS-Co…
William A Schountz · COLORADO STATE UNIVERSITY · 2024 · $2,266,918 — Modified Project Summary/Abstract Section Project Summary / Abstract Bats are reservoirs, or suspected reservoirs, of many zoonotic viruses, including SARS, SARS2 and MERS coronaviruses, Nipah and Hendra viruses, and Ebola and Marburg viruses. Little is known about how these viruses circulate in th…
William A Schountz · COLORADO STATE UNIVERSITY · 2024 · $214,725 — Project Summary / Abstract COVID-19 is caused by a bat-borne coronavirus, SARS-CoV-2, that has resulted in more than 1 million deaths in the USA. Experimental and bioinformatic analyses suggest cricetid rodents, but not murid rodents, may be susceptible to the virus. We determined that two such cric…
Yu-Hua Tseng · JOSLIN DIABETES CENTER · 2024 · $589,365 — Project Summary/Abstract Obesity and its metabolic sequelae are rapidly increasing in the United States and worldwide, leading to high morbidity and mortality in type 2 diabetes, cardiovascular disease, and certain cancer. Under the current pandemic, obesity has been recognized as a key risk factor …
Cara Brook · UNIVERSITY OF CHICAGO · 2024 · $14,293 — Project Summary The wide-reaching impacts of the COVID-19 pandemic highlight the extreme threat posed by the cross-species emergence of zoonotic pathogens. Bats (order: Chiroptera) are the natural reservoir hosts for the majority of the world’s most virulent zoonotic viruses, including Hendra and Ni…
Arinjay Banerjee · WASHINGTON STATE UNIVERSITY · 2023 · $191,789 — Assessing the interferome of novel, purpose-driven bat-derived cells SUMMARY/ABSTRACT Over the last decade, bats have emerged as intriguing mammalian reservoirs of emerging high impact viruses that cause severe disease in humans and agricultural animals. However, bats that are naturally or experime…
Tierra Smiley Evans · UNIVERSITY OF CALIFORNIA AT DAVIS · 2023 · $204,874 — PROJECT SUMMARY Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern pose a global challenge to the effectiveness of existing and future vaccines. This project will address questions surrounding the immunological response to different sarbecovirus exposure patter…