Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Ralph S Baric · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $658,139 — Abstract Zoonotic coronaviruses (CoV) are responsible for three major epidemics/pandemics in the 21st century, including Severe Acute Respiratory Coronavirus (SARS-CoV) in 2003 and the Middle East Respiratory coronavirus (MERS-CoV) in 2012. In Dec 2019, a third novel CoV designated SARS-CoV-2 emerge…
Diane Bimczok · MONTANA STATE UNIVERSITY - BOZEMAN · 2020 · $493,788 — Summary The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious human respiratory tract pathogen that has the capacity to infect many different organ systems, including the gastrointestinal (GI) tract. The overall goal of this project is to elucidate the rol…
Susan R Weiss · UNIVERSITY OF PENNSYLVANIA · 2020 · $283,269 — Middle East respiratory syndrome virus (MERS), a zoonotic lineage C Betacoronavirus discovered in 2012, has caused over 2,000 infections and more than 700 deaths. The emergence of MERS in addition to SARS highlights the public health significance of virulent, emerging coronaviruses (CoVs). MERS is d…
Susan R Weiss · UNIVERSITY OF PENNSYLVANIA · 2020 · $447,595 — Middle East respiratory syndrome virus (MERS), a zoonotic lineage C Betacoronavirus discovered in 2012, has caused over 2,000 infections and more than 700 deaths. The emergence of MERS in addition to SARS highlights the public health significance of virulent, emerging coronaviruses (CoVs). MERS is d…
Susan R Weiss · UNIVERSITY OF PENNSYLVANIA · 2019 · $447,387 — Middle East respiratory syndrome virus (MERS), a zoonotic lineage C Betacoronavirus discovered in 2012, has caused over 2,000 infections and more than 700 deaths. The emergence of MERS in addition to SARS highlights the public health significance of virulent, emerging coronaviruses (CoVs). MERS is d…
Susan C. Baker · LOYOLA UNIVERSITY CHICAGO · 2019 · $705,182 — DESCRIPTION (provided by applicant): The goal of our research is to determine how viral proteases function in the replication and pathogenesis of coronaviruses (CoVs). CoVs are a family of positive strand RNA viruses and include Severe Acute Respiratory Syndrome (SARS) CoV and Middle East Respi…
Jean-Michel HERAUD · PASTEUR INSTITUTE FROM MADAGASCAR · 2019 · $134,653 — Zoonotic pathogens derived from an animal reservoir account for some 60-75% of emerging infectious diseases in humans, a disproportionate number of which take place in resource poor countries where the economic and social burden of corresponding health crises is greatest. Bats have received much att…
Nicolae Valentin David · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $656,337 — PROJECT SUMMARY Intact fibroblast growth factor 23 (iFGF23) is a phosphate regulating hormone secreted by bone. In chronic kidney disease (CKD), increased Fgf23 transcription is associated with cardiovascular mortality, disturbed iron metabolism and anemia. Fgf23 transcription is physiologically cou…
Kyle Stearns · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $48,974 — Project Summary Human parainfluenza viruses (HPIV) cause significant lower respiratory diseases, including croup, bronchiolitis, and pneumonia, that lead to illness or death in millions of infants and young children worldwide. Viral infection is initiated when the viral fusion complex, comprised of …
Stephen Leppla · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $933,913 — There is increasing recognition in the research and development community that the anthrax toxin proteins constitute a uniquely effective tool for delivering materials to the cytosol and nucleus of eukaryotic cells. Our own work with a non-toxic fusion of the N-terminal portion of lethal factor (LF…
Richard Thomas Wyatt · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $739,446 — Abstract Structure-based vaccine design holds great promise for combatting viral pathogens that create substantial burdens on global health. For HIV, the soluble ectodomain of the envelope glycoprotein (Env), which is the primary target for neutralizing antibody responses, is the focal point for …
Richard Thomas Wyatt · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $928,096 — Abstract Structure-based vaccine design holds great promise for combatting viral pathogens that create substantial burdens on global health. For HIV, the soluble ectodomain of the envelope glycoprotein (Env), which is the primary target for neutralizing antibody responses, is the focal point for …
Soon Seog Jeong · HUMAN CELL CO · 2024 · $365,000 — Project Summary Dry eye disease (DED) is an increasingly frequency cause of visual dysfunction. It is characterized by loss of homoeostasis of the ocular surface, resulting in tear film instability, hyperosmolarity, and inflammation of the conjunctiva and cornea. Up to 30% of the population over ag…
Nathalie Pamir · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $510,062 — Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a low-abundance plasma protein that reduces the expression of the LDL receptor (LDLR) and therefore plays a critical role in cholesterol trafficking. Its discovery revolutionized our understanding of cholesterol metabolism, shifting the homeos…
Wing Pui Kong · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $912,113 — Human paramyxoviruses and pneumoviruses are widespread pathogens, cause considerable disease burden. Parainfluenza virus types 1-4 (PIV1-4) are highly infectious human pathogens, of which PIV3 is most commonly responsible for severe respiratory illness in newborns, elderly, and immunocompromised ind…
Maria Blasi · DUKE UNIVERSITY · 2023 · $402,500 — PROJECT ABSTRACT Acute kidney injury (AKI) is a common complication of Coronavirus disease 19 (COVID-19), affecting more than a third of patients hospitalized with COVID-19 and up to 90% of those requiring mechanical ventilation. Possible contributors to AKI in patients with COVID-19 include systemi…
Richard Thomas Wyatt · SCRIPPS RESEARCH INSTITUTE, THE · 2023 · $1,130,492 — Abstract Structure-based vaccine design holds great promise for combatting viral pathogens that create substantial burdens on global health. For HIV, the soluble ectodomain of the envelope glycoprotein (Env), which is the primary target for neutralizing antibody responses, is the focal point for v…
Nicolae Valentin David · NORTHWESTERN UNIVERSITY AT CHICAGO · 2023 · $636,094 — PROJECT SUMMARY Intact fibroblast growth factor 23 (iFGF23) is a phosphate regulating hormone secreted by bone. In chronic kidney disease (CKD), increased Fgf23 transcription is associated with cardiovascular mortality, disturbed iron metabolism and anemia. Fgf23 transcription is physiologically cou…
Samuel K Campos · UNIVERSITY OF ARIZONA · 2023 · $330,893 — Human papillomaviruses (HPVs) are the most common sexually transmitted infection. These viruses infect and replicate in mucosal and cutaneous epithelium, inducing cell proliferation as part of their replicative life cycle. High risk oncogenic HPVs caused over 500,000 cases of cervical cancer worldwi…
Nathalie Pamir · OREGON HEALTH & SCIENCE UNIVERSITY · 2023 · $520,472 — Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a low-abundance plasma protein that reduces the expression of the LDL receptor (LDLR) and therefore plays a critical role in cholesterol trafficking. Its discovery revolutionized our understanding of cholesterol metabolism, shifting the homeos…