Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
XIAOWU PANG · TENGEN BIOMEDICAL CO. · 2023 · $298,530 — Developing Vertebrate-Specific Replication-Defective Dengue Virus as a Novel Single-Cycle Dengue Vaccine Candidate Abstract With an estimated minimum of 390 million dengue virus (DENV) infections per year, the DENV epidemic was listed as one of the world's top 10 public health threats by WHO in 201…
Wing Pui Kong · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $2,480,852 — Human paramyxoviruses and pneumoviruses are widespread pathogens, cause considerable disease burden. Parainfluenza virus types 1-4 (PIV1-4) are highly infectious human pathogens, of which PIV3 is most commonly responsible for severe respiratory illness in newborns, elderly, and immunocompromised ind…
Samuel K Campos · UNIVERSITY OF ARIZONA · 2022 · $331,966 — Human papillomaviruses (HPVs) are the most common sexually transmitted infection. These viruses infect and replicate in mucosal and cutaneous epithelium, inducing cell proliferation as part of their replicative life cycle. High risk oncogenic HPVs caused over 500,000 cases of cervical cancer worldwi…
HERBERT M. GELLER · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2022 · $834,034 — We demonstrated the the Lipid Phosphate Phosphatase-Related Proteins (PLPPRs) can modulate neuronal adhesion and the cytoskeleton through interactions with RhoGDI that modulated both RhoA and Rac1 GTPases. Papers describing these results have been published. PLPPRs, like many transmembrane r…
Valder R. Arruda · CHILDREN'S HOSP OF PHILADELPHIA · 2022 · $732,776 — Project 4 - Abstract Novel approaches to enhance the biologic activity of FVIII and FIX are critical endeavors with potential for improving protein- and gene-based therapy for hemophilia. We have identified novel variants and new strategies that have a positive effect on the biological activity of F…
Maria Blasi · DUKE UNIVERSITY · 2022 · $402,500 — PROJECT ABSTRACT Acute kidney injury (AKI) is a common complication of Coronavirus disease 19 (COVID-19), affecting more than a third of patients hospitalized with COVID-19 and up to 90% of those requiring mechanical ventilation. Possible contributors to AKI in patients with COVID-19 include systemi…
Nathalie Pamir · OREGON HEALTH & SCIENCE UNIVERSITY · 2022 · $520,472 — Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a low-abundance plasma protein that reduces the expression of the LDL receptor (LDLR) and therefore plays a critical role in cholesterol trafficking. Its discovery revolutionized our understanding of cholesterol metabolism, shifting the homeos…
XIAOWU PANG · TENGEN BIOMEDICAL CO. · 2022 · $298,530 — Developing Vertebrate-Specific Replication-Defective Dengue Virus as a Novel Single-Cycle Dengue Vaccine Candidate Abstract With an estimated minimum of 390 million dengue virus (DENV) infections per year, the DENV epidemic was listed as one of the world's top 10 public health threats by WHO in 201…
SHUPING TONG · RHODE ISLAND HOSPITAL · 2022 · $205,000 — Project Summary/Abstract Chronic infection by hepatitis B virus (HBV) is a leading cause of liver cancer worldwide, which can be promoted by hepatitis B e antigen (HBeAg) through induction of immune tolerance. Since HBeAg loss is a therapeutic goal, it is critically important to identify the host e…
Andrew Barrett Ward · SCRIPPS RESEARCH INSTITUTE, THE · 2022 · $621,250 — Abstract Structure-based vaccine design holds great promise for combatting viral pathogens that create substantial burdens on global health. For HIV, the soluble ectodomain of the envelope glycoprotein (Env), which is the primary target for neutralizing antibody responses, is the focal point for va…
Samuel K Campos · UNIVERSITY OF ARIZONA · 2021 · $332,959 — Human papillomaviruses (HPVs) are the most common sexually transmitted infection. These viruses infect and replicate in mucosal and cutaneous epithelium, inducing cell proliferation as part of their replicative life cycle. High risk oncogenic HPVs caused over 500,000 cases of cervical cancer worldwi…
Nathalie Pamir · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $517,392 — Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a low-abundance plasma protein that reduces the expression of the LDL receptor (LDLR) and therefore plays a critical role in cholesterol trafficking. Its discovery revolutionized our understanding of cholesterol metabolism, shifting the homeos…
SHUPING TONG · RHODE ISLAND HOSPITAL · 2021 · $245,875 — Project Summary/Abstract Chronic infection by hepatitis B virus (HBV) is a leading cause of liver cancer worldwide, which can be promoted by hepatitis B e antigen (HBeAg) through induction of immune tolerance. Since HBeAg loss is a therapeutic goal, it is critically important to identify the host e…
Stephen Leppla · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $996,718 — Our long-term basic research on anthrax vaccines has included work on next generation candidates that induce antibody to the poly-gamma-D-glutamic acid (PGA) capsule as well as to the protective antigen protein (PA). A candidate conjugate vaccine developed in collaboration with Drs. John Robbins and…
Mihaela Serpe · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2021 · $1,506,675 — The long-term goal of this project is to define molecular mechanisms that control synapse assembly, development and homeostasis. Drosophila NMJ is a glutamatergic synapse, similar in structure and physiology to mammalian central excitatory synapses. In flies each NMJ is unique and identifiable, syna…
Valder R. Arruda · CHILDREN'S HOSP OF PHILADELPHIA · 2021 · $732,776 — Project 4 - Abstract Novel approaches to enhance the biologic activity of FVIII and FIX are critical endeavors with potential for improving protein- and gene-based therapy for hemophilia. We have identified novel variants and new strategies that have a positive effect on the biological activity of F…
Tianxin Yang · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2021 · $528,448 — (Pro)renin receptor (PRR) binds prorenin/renin in vitro to increase their catalytic activity and therefore is postulated to be a regulator of renin. Soluble PRR (sPRR) residing in the extracellular domain of PRR is produced by furin or ADAM19-dependent cleavage process and has been widely studied as…
Gonzalo Izaguirre · UNIVERSITY OF ILLINOIS AT CHICAGO · 2021 · $197,894 — Abstract Many human pathogenic viruses exploit the host-cell proteases of the proprotein convertase (PC) family for their own benefit. The proteolytic processing of viral surface proteins is a mechanism by which viruses regulate their infectivity. The crucial role of the proteolytic regulation of vi…
Maria Blasi · DUKE UNIVERSITY · 2021 · $402,500 — PROJECT ABSTRACT Acute kidney injury (AKI) is a common complication of Coronavirus disease 19 (COVID-19), affecting more than a third of patients hospitalized with COVID-19 and up to 90% of those requiring mechanical ventilation. Possible contributors to AKI in patients with COVID-19 include systemi…
Andrew Barrett Ward · SCRIPPS RESEARCH INSTITUTE, THE · 2021 · $621,250 — Abstract Structure-based vaccine design holds great promise for combatting viral pathogens that create substantial burdens on global health. For HIV, the soluble ectodomain of the envelope glycoprotein (Env), which is the primary target for neutralizing antibody responses, is the focal point for va…