Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Jeffery Micheal Tharp · INDIANA UNIVERSITY INDIANAPOLIS · 2023 · $249,000 — PROJECT SUMMARY Bicyclic peptides are conformationally constrained peptides comprised of two macrocyclic rings. Owing to their increased rigidity, bicyclic peptides can bind to protein targets with greater affinity and selectivity than their linear and monocyclic counterparts. As a result, these mol…
Dan H. Barouch · FRED HUTCHINSON CANCER CENTER · 2023 · $2,683,830 — FOA: PA-20-272: Administrative Supplements to Existing NIH Grants and Cooperative Agreements Activity Code/Award: UM1/A1068614-15 (parent award) ------------------------------------------------------------------------------------ Project Abstract This proposal outlines the scientific agenda for the …
SAMUEL JEREMY PLEASURE · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $629,459 — PROJECT SUMMARY COVID-19 is associated with a growing number of peripheral and central nervous system complications. It has become clear that a subset of these syndromes, including acute necrotizing encephalopathy, steroid- responsive encephalitis and Guillain-Barré syndrome, are likely due to dire…
MARCUS AARON HORWITZ · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2023 · $549,664 — Project Summary/Abstract Francisella tularensis is a bacterium that causes tularemia, a disease which, when in its pneumonic form, can be fatal even with appropriate treatment. Due to its low infectious dose, ease of spread by aerosol, and high virulence, F. tularensis is classified as a Tier 1 Sele…
L Lee HAMM · TULANE UNIVERSITY OF LOUISIANA · 2023 · $311,220 — PROJECT SUMMARY This application is a supplement request to our P51 base grant to Tulane National Primate Research Center (TNPRC) to further the investigation of the Post-Acute Sequelae of SARS-CoV-2 infection (PASC). This application investigates the overarching hypothesis that SARS-CoV-2-induced d…
BARSANJIT MAZUMDER · CLEVELAND STATE UNIVERSITY · 2023 · $222,750 — Adopted folding of the RNA elements within the genomes of RNA viruses allows binding of host and viral proteins and plays an essential role in host-virus interactions. However, the mechanistic insights on how these RNA elements could sense the transduced signals from host cells are lacking for SARS-…
Alvin Yu · UNIVERSITY OF CALIFORNIA-IRVINE · 2023 · $249,000 — PROJECT SUMMARY Viruses are infectious agents that replicate inside the living cells of an organism, and it remains critical to understand the basic molecular mechanisms that govern viral replication, as they perform numerous complex physical and chemical processes ranging from atomic-scale phenomen…
YOSHIHIRO KAWAOKA · UNIVERSITY OF WISCONSIN-MADISON · 2023 · $4,618,169 — SUMMARY Most of the vaccines currently approved or in development against the pandemic SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus target immunodominant, strain-specific epitopes in the SARS-CoV-2 spike (S) protein and are therefore not expected to confer protection against o…
JUAN M SAAVEDRA · GEORGETOWN UNIVERSITY · 2023 · $623,584 — SARS-CoV-2, the virus underlying the current COVID-19 pandemic, not only affects peripheral tissues, it also targets the brain causing microvascular lesions, microhemorrhages and neurological manifestations. The internalization of SARS-CoV-2 is initiated by the binding of the virus spike protein to …
Gabriela Cristina Brailoiu · TEMPLE UNIV OF THE COMMONWEALTH · 2023 · $476,255 — SARS-CoV-2, the virus that causes COVID-10, impacts multiple organ systems including the central nervous system. Neurological symptoms are seen in about one third of COVID-19 patients and the virus has been found in brain tissue. SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) located on cell…
Paul D. Bieniasz · ROCKEFELLER UNIVERSITY · 2023 · $4,259,011 — ABSTRACT-OVERALL The recurrent emergence of coronaviruses from animal reservoirs, and the resulting COVID19 pandemic, necessitates the development of interventions that can target diverse pandemic-threat coronaviruses. Vaccines are among the most powerful means for mitigating viral epidemics but re…
Nitesh K Kunda · ST. JOHN'S UNIVERSITY · 2023 · $164,000 — Summary Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) is a highly infectious virus known to cause the 2019 coronavirus disease (COVID-19). The disease has been declared as a global pandemic by the World Health Organization. In the United States, as of January 20, 2021, we have more th…
Yingjie Chen · PURDUE UNIVERSITY · 2023 · $122,453 — Project Summary Cryo-electron microscopy (cryoEM) revolutionized structural biology, providing a powerful method to study biological specimens in their native environment. However, a major bottleneck hindering the wider use of cryoEM is the lack of trained professionals capable of proficiently opera…
Lisa A Cavacini · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2023 · $694,551 — Project Summary The coronavirus disease 2019 (COVID-19) rapidly disseminated through the human population and became a global pandemic. Significant efforts have been put into developing vaccines or antibody therapies based on the spike glycoprotein of SARS-CoV-2. One challenge of such strategies is …
Masashi Tabuchi · CASE WESTERN RESERVE UNIVERSITY · 2023 · $386,030 — Project Summary/Abstract The idea that information processing depends on neuronal firing rate (rate coding) has long been a central dogma in neurobiology. However, other non-canonical coding schemes (temporal and “analog” codes) have been proposed to carry meaningful information and be more computat…
David Michael Markovitz · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2023 · $728,193 — The huge loss of life and major damage to the social fabric that is caused by a viral pandemic has been brought graphically to light with the current SARS-CoV-2 (COVID-19) crisis. Clearly, broad-spectrum antiviral agents that are effective therapeutically and prophylactically against SARS-CoV-2, ant…
Sanja Arandjelovic · UNIVERSITY OF VIRGINIA · 2023 · $493,956 — UNDERSTANDING A MOLECULAR CASCADE THAT DRIVES NEUTROPHIL MEDIATED PATHOLOGY IN ARTHRITIS Rheumatoid arthritis (RA) is a frequent chronic disease of the synovial joints characterized by painful loss of mobility due to unrestrained inflammation and progressive bone erosion. Disease etiology is poorly…
Lanying Du · GEORGIA STATE UNIVERSITY · 2023 · $759,331 — Summary A novel coronavirus (CoV), SARS-CoV-2, is causing global pandemics with growing numbers of daily cases and deaths. SARS-CoV-2 is closely related to SARS-CoV, which caused the 2002-2003 SARS epidemic, and less closely related to MERS-CoV, which causes a high mortality rate in infected patient…
Joana Almaca · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2023 · $383,750 — ABSTRACT The coronavirus disease 2019 (COVID-19) is a global healthcare crisis that in the USA kills about 1 person every minute. It is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). While respiratory failure is still the most common cause of mortality in COVID-19 patien…
L Lee HAMM · TULANE UNIVERSITY OF LOUISIANA · 2023 · $9,304,973 — Project Summary – Overall The Tulane National Primate Research Center (TNPRC) is affiliated with Tulane University of Louisiana and was dedicated in 1964. The Center is part of Tulane University Health Sciences along with the School of Medicine, the School of Public Health and Tropical Medicine, and…