Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Siyuan Ding · WASHINGTON UNIVERSITY · 2024 · $155,500 — Project Summary Diarrheal diseases account for 1 in 10 child deaths worldwide. Rotavirus (RV) and enterotoxigenic Escherichia coli (ETEC) are major etiological causes of acute gastroenteritis and severe diarrhea worldwide, together resulting in approximately 300,000 deaths each year, mostly in chil…
Elias Sayour · UNIVERSITY OF FLORIDA · 2024 · $597,571 — Project Summary Immunotherapy has shown profound benefit for adult patients but has yet to be fully unlocked for pediatric solid tumors such as osteosarcoma (OSA) where a significant percentage of children/adolescents succumb due to the presence of lung metastasis. OSA, like many poorly tumor immuno…
Michael S Diamond · WASHINGTON UNIVERSITY · 2024 · $46,715,173 — SUMMARY. The Flavivirus and Alphavirus ReVAMPP (FLARE) Center will develop and optimize protein nanoparticle, virion-based, and mRNA vaccine platforms, and monoclonal antibody (mAb)-based treatments to rapidly respond to emerging flaviviruses and alphaviruses with pandemic potential. A key goal is t…
Eleftherios Michailidis · EMORY UNIVERSITY · 2024 · $195,625 — Project Summary There are approximately a quarter of a billion people worldwide chronically infected with hepatitis B virus (HBV) who are at risk of developing liver cirrhosis and hepatocellular carcinoma. The loss of life due to HBV-related complications each year is about 820,000 people. At the sa…
SAAD BHAMLA · GEORGIA INSTITUTE OF TECHNOLOGY · 2024 · $263,399 — Project Summary/Abstract Given modern history’s advancements in molecular biology, from the exponential decrease in the costs of genome sequencing, nucleotide synthesis, and genome editing (CRISPR), synthetic biology is poised to be the next major revolution in technological advancements. The White …
Alkesh Harihar Jani · VA EASTERN COLORADO HEALTH CARE SYSTEM · 2024 — Bacterial infections are the second leading cause of death in ESRD. The incidence of pneumonia amongst dialysis patients is increasing and leads to a mortality rate that is 14-16-fold greater than pneumonia in the general population. Little is known regarding the immune response to pneumococcal vacc…
Rhiju Das · STANFORD UNIVERSITY · 2024 · $684,690 — PROJECT SUMMARY The continuing discoveries of RNAs and their critical roles in cellular and viral machinery are inspiring novel antibacterial, antitumor, antiviral, and genome-editing therapies based on disabling, manipulating, and repurposing the RNAs involved. Unfortunately, our poor biophysical u…
Ken A Halvorsen · STATE UNIVERSITY OF NEW YORK AT ALBANY · 2024 · $430,375 — Project Summary Our vision is to develop, apply, and advance new technologies in the broad thematic program of the manipulation of nucleic acids. The research largely focuses on RNA-based applications, which is both driven and enhanced by our unique environment at The RNA Institute, enabling easy co…
Yang Xu · LUNA LABS USA, LLC · 2024 · $903,639 — Project Summary Significant research has gone into the development of a safe and effective vaccine for HIV-1. Although many strategies have been attempted; none has been successfully established. Even a partially effective vaccine could decrease the number of people who are infected with HIV, furthe…
ERIC T. KOOL · STANFORD UNIVERSITY · 2024 · $12,184 — Summary of parent project (R35 GM145357) Work in the last decade from many labs has underlined the critical importance of RNA-mediated cellular pathways, and clear connections of specific RNAs to human health. RNAs are increasingly viewed both as appealing therapeutic targets, and as therapeutic age…
Nerea Zabaleta · SCHEPENS EYE RESEARCH INSTITUTE · 2024 · $668,569 — SUMMARY/ABSTRACT Broadening the spectrum of vaccine platforms that confer protective, durable and broad immunogenicity is important for pandemic preparedness. Here, we aim to create essential preclinical data to characterize a novel genetic vaccine platform called PARVAX to increase its clinical acc…
Kay Lynn Medina · MAYO CLINIC ROCHESTER · 2024 · $318,000 — PROJECT SUMMARY Steady-state hematopoiesis in bone marrow is critical for maintenance of blood cell genesis and immune competence throughout life. Concomitant with aging, the bone marrow hematopoietic stem cell (HSC) compartment undergoes cell intrinsic and extrinsic changes that biases hematopoieti…
David E Verhoeven · IOWA STATE UNIVERSITY · 2024 · $225,370 — PROJECT SUMMARY / ABSTRACT Highly pathogenic and low pathogenic strains of avian influenza continue to circulate and infect birds in Asia with occa- sional spread into the North American flyway. These necessitate the culling of any poultry farms that test positive for these strains. Furthermore, th…
STEPHEN K BURLEY · RUTGERS, THE STATE UNIV OF N.J. · 2024 · $3,880,000 — The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) works with community stakeholders to preserve and deliver rigorously-validated, expertly-biocurated, three-dimensional (3D) biostructure information archived in the Protein Data Bank (PDB) to many millions of Depos…
Kirk David Christian Jensen · UNIVERSITY OF CALIFORNIA, MERCED · 2024 · $219,554 — PROJECT SUMMARY_____________________________________________________________________ Parasitic diseases remain a problem worldwide largely due to the lack of vaccines to effectively interrupt transmission or infection, as parasites often develop resistance to drugs. A combination of different factor…
Ross M Kedl · UNIVERSITY OF COLORADO DENVER · 2024 · $460,469 — PROJECT SUMMARY Due to the overwhelming success of the new mRNA vaccines during the SARS-CoV2 pandemic, vaccines have entered the public consciousness to a level not seen since the days of smallpox eradication and the polio epidemic. It seems reasonable to assume that the established rules governing…
CAROLINE E CAMERON · UNIVERSITY OF VICTORIA · 2024 · $1,622,474 — PROJECT SUMMARY In several high-income nations, including the United States, infectious syphilis has been resurgent for over two decades now, while syphilis is still endemic in low- and middle-income countries. Syphilis is therefore still a public global health concern, particularly because it can …
JOSHUA D NOSANCHUK · FUNDACAO OSWALDO CRUZ · 2024 · $115,880 — An extracellular vesicle component as a candidate to control cryptococcosis. SUMMARY Fungal diseases are a major threat to immunocompromised patients. Cryptococcosis, caused by members of the Cryptococcus genus, is responsible for nearly 200,000 deaths worldwide annually. Immunocompromised individua…
Michael R. Farzan · BOSTON CHILDREN'S HOSPITAL · 2024 · $265,500 — ABSTRACT Both private entities and academic groups are pioneering B cell editing for therapeutic purposes, either to express therapeutic antibodies from their native Ig loci, or other transgenes from an ectopic locus. BCR editing is currently performed with CRISPR/Cas system and a homology- directed…
Paolo Cravedi · PALO ALTO VETERANS INSTIT FOR RESEARCH · 2023 · $255,459 — PROJECT SUMMARY / ABSTRACT Solid organ transplant recipients have increased morbidity and mortality in response to infection with SARS- CoV-2, the virus responsible for COVID19. While the general population has greatly benefited from the rapid development of several vaccines that are protective agai…