Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Elana Ben-Akiva · JOHNS HOPKINS UNIVERSITY · 2020 · $45,520 — The overall goal of this project is to engineer novel biodegradable cationic polymers for intracellular delivery of nucleic acid materials to antigen presenting cells (APCs) for cancer immunotherapy applications. Immune cells are conventionally very difficult to transfect, and the most successful pl…
JOSEPH M FOX · UNIVERSITY OF DELAWARE · 2020 · $2,349,582 — Project Summary The goal of this Center of Biomedical Research Excellence is to continue our efforts to develop molecular approaches for probing biology, to discover and apply new chemical biology tools for the study of biological pathways associated with disease, and to develop computational approa…
Michael Daniel Keller · CHILDREN'S RESEARCH INSTITUTE · 2020 · $89,250 — Abstract Chronic norovirus infection can cause chronic diarrhea and wasting in immunocompromised patients, including those undergoing hematopoietic stem cell transplantation and with primary immunodeficiency disorders. There are currently no available therapies to treat norovirus. Our preliminary da…
Derek B. Sant'Angelo · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · 2020 · $477,000 — Summary There are at least 49 members of the BTB-ZF gene family, which includes PLZF, BCL6, ThPOK, LRF and others. Only a few have been studied in the context of immune system development or function. Expression of the known BTB-ZF genes correlates with specific functions of the cells – in many ways…
Hui Hu · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2020 · $491,617 — Project Summary CD4+ T follicular helper (Tfh) cells are essential for germinal center (GC) responses and long- term humoral immunity. However, the complex regulation that determines the differentiation of Tfh cells, their developmental progression in GC, and their number and function in helping GC…
Natalie Lea Silver · UNIVERSITY OF FLORIDA · 2020 · $155,304 — PROJECT SUMMARY/ABSTRACT Oral cavity squamous cell carcinoma (OCSCC) is a very aggressive and deadly disease with poor survival rates following maximal treatments such as surgery and chemoradiotherapy. The immunosuppressive tumor microenvironment (TME) is a major barrier of response to traditional …
YASUHIRO SUZUKI · UNIVERSITY OF KENTUCKY · 2020 · $459,000 — Chronic infection with Toxoplasma gondii can reactivate and cause life-threatening toxoplasmic encephalitis in AIDS patients and other immunocompromised individuals. The basis of persistence of this chronic infection is the tissue cyst. Thus, eliminating T. gondii cysts from chronically infected ind…
Esteban Daniel Erben · RBHS-NEW JERSEY MEDICAL SCHOOL · 2020 · $185,166 — PROJECT SUMMARY Trypanosoma brucei causes African trypanosomiasis in humans and livestock. In the mammalian infectious Bloodstream-Form (BF) stage, T. brucei expresses a single species of Variant Surface Glycoprotein (VSG) genes from over 2,500 VSG repertoire with a potential of switching to a diffe…
Scheherazade Sadegh-Nasseri · JOHNS HOPKINS UNIVERSITY · 2020 · $543,021 — Unconventional sources of peptides for antigen presentation Project Abstract The long term goals of this project are to understand how the antigen processing pathway generates peptide/MHC class I complexes (pMHC I) by cryptic translation. Numerous studies, from different laboratories, have shown th…
Rachel Riley · UNIVERSITY OF PENNSYLVANIA · 2020 · $9,473 — PROJECT SUMMARY Recent advances in genome sequencing has enabled the detection of random somatic mutations, or neoantigens, in cancer cells from individual patient samples. Thus, neoantigens are ideal targets for cancer vaccination because they avoid harmful toxicities to healthy cells, and they are…
Jae U Jung · UNIVERSITY OF SOUTHERN CALIFORNIA · 2020 · $26,293 — Project Summary/Abstract The massive outbreak of newly emerged coronavirus disease 2019 (COVID-19) has been rapidly spread worldwide, leading to a pandemic infection and serious global health emergency. In order to prevent further dissemination of severe acute respiratory syndrome coronavirus 2 (SA…
TORU TAKIMOTO · UNIVERSITY OF ROCHESTER · 2020 · $385,000 — Virus infection induces a wide range of host defense mechanisms, such as the innate immune response and inflammation. Some viruses express accessory proteins to induce general shutoff of host protein synthesis, which is considered to be one of the major viral strategies to counteract host antiviral …
Nan-ping Peter Weng · NATIONAL INSTITUTE ON AGING · 2020 · $275,992 — Maintenance of telomeres is essential for preserving T cell proliferative responses yet the precise role of telomerase in human T cell differentiation, function and aging is not fully understood. Here we analyzed human telomerase reverse transcriptase (hTERT) expression and telomerase activity in si…
Bernard Moss · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $574,999 — Poxviruses encode enzymes and factors needed for transcription and replication of their genomes within the cytoplasm of infected cells. Vaccinia virus, the prototypic member of the poxvirus family, provides a unique system for combining biochemical and genetic approaches for investigating mechanisms…
BRIAN KELSALL · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $1,630,774 — This project focuses on the roles of different populations of dendritic cells (DC) and macrophages (MP) in immune responses in mucosal tissues. While it is clear that the normal outcome of mucosal antigen exposure can be positive, i.e., the development of intestinal IgA and effector T cell responses…
Joseph Shiloach · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2020 · $280,498 — The following are couple of examples the first is the Effect of restricted dissolved oxygen on expression of Clostridium difficile toxin A submit from E. coli. And the second is related to expression of protein from pichia pastoris The repeating unit of the C. difficile Toxin A (rARU, also known as…
RICHARD J. HODES · DIVISION OF BASIC SCIENCES - NCI · 2020 · $361,631 — The src family kinase lck plays a critical role in T lymphocyte development and activation. Expression of lck is regulated by two promoters, termed distal and proximal promoters, in both mice and humans. Although the existence of these promoters was described 20 years ago, their function in developi…
Patrick Duffy · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $3,037,907 — In FY2020, LMIV scientists contributed to 1 publication on conjugate or particle vaccines, and we describe progress reported in those manuscripts here: 1. In published work, we observed that alternate carriers increase antibody titers of Pfs25 & Pfs230 above benchmark EPA carrier; TBV antigens conj…
BARBARA K FELBER · DIVISION OF BASIC SCIENCES - NCI · 2020 · $1,866,900 — Our recognition of the fundamental mechanisms mRNA expression, exemplified by the regulated expression of HIV, provided the basics for our interest in developing preventive HIV DNA based vaccine strategies. Attractive features of the DNA platform lie in its simplicity, versatility, stability, with r…
DONALD Lawrence SIEGEL · UNIVERSITY OF PENNSYLVANIA · 2020 · $179,023 — SUMMARY CORE B: GMP CELL and RNA MANUFACTURING Core B is the Clinical Cell and Vaccine Production Facility (CVPF). The CVPF is a Foundation for the Accreditation of Cellular Therapy (FACT)-accredited, Good Manufacturing Practices (GMP) compliant cell and RNA manufacturing facility. This facility …