Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
AMIT KHANDHAR · PAI LIFE SCIENCES, INC. · 2019 · $299,184 — Effective Targeted Delivery of RNA-based Vaccines and Therapeutics: RNA-based vaccines and therapeutics have emerged as great promise for HIV prevention and treatment, respectively. However, many obstacles still need to be overcome, in particular RNA instability, manufacturing problems, and clinica…
Beatrice H Hahn · UNIVERSITY OF PENNSYLVANIA · 2019 · $880,342 — PROJECT SUMMARY A central goal in HIV/AIDS vaccine research is the elicitation of broadly neutralizing antibodies (bNAbs). Here, we propose to leverage three recent discoveries from our groups to generate novel envelope (Env) immunogens that target the V1V2 region of the trimer…
Harvey Michael Friedman · UNIVERSITY OF PENNSYLVANIA · 2019 · $818,356 — Abstract A vaccine for prevention of genital herpes is a high public health priority. Herpes vaccines that performed well in rodents have not protected humans; therefore, novel approaches are needed. We propose the following: 1) Set a much higher bar for vaccine efficacy in animal models than used p…
CHRISTOPHER A BENEDICT · LA JOLLA INSTITUTE FOR IMMUNOLOGY · 2019 · $720,659 — Summary Cytomegalovirus (CMV, a b-herpesvirus) establishes a persistent infection that is endemic in humans and mice. CMV causes acute clinical disease only if immunity is naïve or compromised, exemplifying how coevolution with its host over millennia has resulted in a largely non-pathogenic détente…
Elias Sayour · UNIVERSITY OF FLORIDA · 2019 · $158,188 — Abstract: I am now in my first faculty position as an Assistant Professor of Neurosurgery and Pediatrics at the University of Florida. I completed a T32 NIH fellowship at Duke University in Cancer Biology and Developmental Therapeutics before accepting a junior faculty position at the University of …
Norbert Pardi · UNIVERSITY OF PENNSYLVANIA · 2019 · $640,818 — ABSTRACT Influenza virus is one of the most important human infectious diseases. The influenza mortality is estimated to be approximately 650,000 per year worldwide, in addition, occasional global pandemics can infect up to 20- 40% of the world's population. Licensed influenza virus vaccines require…
BRUNO DE BEZERRIL ANDRADE · VANDERBILT UNIVERSITY MEDICAL CENTER · 2019 · $726,648 — PROJECT SUMMARY Recent studies from our group have reported a peripheral blood correlate of risk (COR) transcriptional signature that identified individuals with incipient (asymptomatic) TB who progressed to active (symptomatic) TB disease within 12 months. We have also identified human genetic poly…
JOHN N GALGIANI · UNIVERSITY OF ARIZONA · 2019 · $579,122 — Project Summary Coccidioidomycosis (Valley Fever) is a serious public health problem for the Southwestern United States and all who visit there. A small proportion of infections result in progressive, debilitating, even life-threatening illness (disseminated coccidioidomycosis or DCM). All evidence …
Edward N Janoff · VA EASTERN COLORADO HEALTH CARE SYSTEM · 2019 — 7. Project Summary/Abstract Both advancing age and HIV-1 infection are associated with an increased frequency of infection, such as those due to Streptococcus pneumoniae, and a higher rate of complications and death with these infections. Vaccines are available to prevent a number of infections comm…
Alexander Bukreyev · UNIVERSITY OF TEXAS MED BR GALVESTON · 2019 · $825,853 — PROJECT SUMMARY/ABSTRACT The Marburg virus (MARV) and Ravn virus (RAVV), which both belong to the genus Marburgvirus of the family Filoviridae, cause the severe disease in humans, with case fatality rates up to 90%. There are no licensed vaccines against marburgviruses. Clinical trials of vaccine ca…
Kimberly D. Klonowski · UNIVERSITY OF GEORGIA · 2019 · $225,625 — Abstract Identifying the mechanisms that regulate CD8 T cell responses is critical for improving anti-viral and anti-tumor vaccine efficacy and is currently an area of intense investigation due to the profound implications for improving human health. The goal of this application is to determine the …
Kristyn Rene Aalto · ORLANCE, INC. · 2019 · $298,613 — Gene gun delivery of DNA vaccines, also known as particle mediated epidermal delivery or PMED, delivers DNA vaccines coated onto 1 micron sized gold particles directly into cells of the epidermis. It achieves pain-free delivery, is considerably more efficient than electroporation or other DNA vaccin…
Toni Darville · UNIV OF NORTH CAROLINA CHAPEL HILL · 2019 · $808,098 — DESCRIPTION (provided by applicant): Chlamydia trachomatis infection is the leading cause of infertility and ectopic pregnancy in women. Infection is often asymptomatic, leading to lack of detection, increased risk for disease and delay in treatment. Although antibiotic therapy eliminates infec…
TORU TAKIMOTO · UNIVERSITY OF ROCHESTER · 2019 · $385,000 — Virus infection induces a wide range of host defense mechanisms, such as the innate immune response and inflammation. Some viruses express accessory proteins to induce general shutoff of host protein synthesis, which is considered to be one of the major viral strategies to counteract host antiviral …
Brian D. Green · GLYCOBIA, INC. · 2019 · $300,000 — PROJECT SUMMARY/ABSTRACT Almost half of all men and women in the United States will be diagnosed with cancer during their lifetimes, resulting in more than 500,000 deaths and an economic burden exceeding $200 billion annually. Cancer immunotherapies, such as vaccines and antibodies, are emerging str…
Eva Maria Carmona Porquera · MAYO CLINIC ROCHESTER · 2019 · $79,500 — PROJECT SUMMARY/ABSTRACT B-cells are increasingly linked to a number of fibrotic lung diseases (FLD) and it is well recognized that they form aggregates, known as inducible bronchus associated lymphoid tissue (iBALTs) in the lung of many of these patients. Our studies demonstrate that when activated…
Derek B. Sant'Angelo · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · 2019 · $477,000 — Summary There are at least 49 members of the BTB-ZF gene family, which includes PLZF, BCL6, ThPOK, LRF and others. Only a few have been studied in the context of immune system development or function. Expression of the known BTB-ZF genes correlates with specific functions of the cells – in many ways…
Scott G Hansen · OREGON HEALTH & SCIENCE UNIVERSITY · 2019 · $819,581 — Project Summary With 36 million people currently living with HIV worldwide, developing a prophylactic HIV vaccine that protects against sexual transmission remains a top global health priority. A pre-clinical HIV vaccine approach based on strain 68-1 of rhesus cytomegalovirus expressing SIV antigens…
Beatrice H Hahn · UNIVERSITY OF PENNSYLVANIA · 2019 · $800,558 — PROJECT SUMMARY Studying Natural SIV Reservoirs and Human Zoonotic Risk, we discovered in the last funding period that certain strains of SIV infecting Old World monkeys and African apes share unexpected antigenic cross- reactivity with HIV-1 in the functionally important V1V2 region of the envelope…
ROBERT A SEDER · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $350,000 — NHP immunized with 10 and 100g of mRNA-1273 encoding the SARS CoV2 had robust neutralizing antibodiy titers following two immunizations. mRNA-1273 induced Th1-biased CD4 T cell responses and low or undetectable Th2 or CD8 T responses. Following an infectious challenge with SARS CoV2 by the intrana…