Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
vineet n kewalramani · DIVISION OF BASIC SCIENCES - NCI · 2022 · $395,790 — Using lentiviral vectors pseudotyped with SARS-CoV-2 Spike protein, we are examining different SARS-CoV-2 variants for their ability to interact with CLEC4M, and whether this interaction facilitates direct infection of cells or efficient transfer and infection of cells expressing cano…
Nadya Tarasova · DIVISION OF BASIC SCIENCES - NCI · 2022 · $22,698 — The reliability, and consequently success of virtual screening depends heavily on the accuracy of the x-ray structure depiction of the target protein structure in solution. Crystal packing can distort conformation of flexible parts of the protein thus leading to misrepresentation of t…
BALI PULENDRAN · UNIVERSITY OF WASHINGTON · 2022 · $1,377,304 — PROJECT SUMMARY– PROJECT 3: Mechanistic studies and comparisons of vaccines in preclinical models The two primary goals of the Project are to: (i) define the immunological parameters (i.e., CD4+ T cell help; innate immune response) that regulate the breadth of the antibody response in mechanistic st…
JEFFREY S GLENN · STANFORD UNIVERSITY · 2022 · $8,915,196 — ABSTRACT: Our overall objective is to develop a novel class of outpatient therapeutics targeting highly- conserved RNA structures in the genomes of SARS-CoV-2 and other respiratory viruses of pandemic potential. Using influenza A virus (IAV) as a proof-of-concept, we previously showed that: 1) addin…
SABRA L. KLEIN · JOHNS HOPKINS UNIVERSITY · 2022 · $432,172 — Research Project 3 Summary There are insufficient data regarding the long-term humoral immune responses induced after SARS-CoV-2 infection. Our preliminary data indicate that there is variation in the magnitude and duration of antibody responses following SARS-CoV-2 infection. While IgG and IgA anti…
Neil King · UNIVERSITY OF WASHINGTON · 2022 · $792,967 — PROJECT SUMMARY – PROJECT 2: Structure-based antigen and nanoparticle vaccine design Project 2 is focused on the design, production, and characterization of novel stabilized antigens and broadly protective nanoparticle vaccines. In Aim 1, we will establish automated computational pipelines that iden…
Daniel Kulp · WISTAR INSTITUTE · 2022 · $1,244,471 — Project Summary The first project of our pan-CoV proposal is titled ‘Development of broad nanovaccines targeting diverse coronavirus receptor-binding sites’. Our team’s expertise will culminate in structurally guided coronavirus nanoparticle vaccines to broaden CoV vaccine protection. This proposal …
Gabriela Cristina Brailoiu · TEMPLE UNIV OF THE COMMONWEALTH · 2022 · $493,148 — SARS-CoV-2, the virus that causes COVID-10, impacts multiple organ systems including the central nervous system. Neurological symptoms are seen in about one third of COVID-19 patients and the virus has been found in brain tissue. SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) located on cell…
JOHN S. LAZO · KEVIRX INC. · 2022 · $6,500 — The Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) is responsible for the current COVID-19 pandemic. SAR-CoV-2, like other coronaviruses, infects human airways and enters cells via its S (Spike) protein, which binds to the human angiotensin-converting enzyme 2 (ACE2) and is primed by the…
HAFIZ AHMED · GLYCOMANTRA, INC. · 2022 · $300,000 — Project Summary/Abstract The COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), is a global pandemic with catastrophic consequences for healthcare systems and populations. The increased morbidity and mortality in older persons and those with diabetes (12-22%) and h…
Paras Patel · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2022 · $15,534 — PROJECT SUMMARY Understanding how different regions of the central nervous system (CNS) are affected by genetic insults is critical to advancing the study of CNS pathologies which present a major public health burden in the United States. The cerebellum and optic nerve are two such regions that are …
Santimukul Santra · PITTSBURG STATE UNIVERSITY · 2022 · $76,946 — Program Director/Principal Investigator: Santra, Santimukul PROJECT SUMMARY/ABSTRACT This application proposes to develop liposome-coated iron oxide nanosensors (LIONs) mimicking as magnetically-labeled host membranes to detect fusion interactions of enveloped viruses. Spin-spin T2 relaxation techn…
WALTHER H MOTHES · YALE UNIVERSITY · 2022 · $828,211 — Summary The COVID19 pandemic may take 1-3 years and only fully subside once we reach herd immunity. Given the high mortality of COVID19, it is of critical importance to reach herd immunity through a vaccine. The viral spike glycoprotein (S) is central to our efforts for developing an effective vacci…
JEFFREY J DESTEFANO · UNIV OF MARYLAND, COLLEGE PARK · 2022 · $193,125 — The impact of SARS-CoV-2 on public health and the global economy cannot be overstated. As of September 28, 2020, 33,224,222 cases and 999,298 deaths worldwide have been linked to this emergent virus. This staggering number continues to grow, with the United States baring disproportionately high rate…
AILONG KE · CORNELL UNIVERSITY · 2022 · $686,255 — Project Summary The current SARS-CoV-2 pandemic poses an immediate and global public health threat. This is the third major zoonotic-born coronavirus outbreak in humans in the past twenty years, after SARS-CoV-1 and MERS-CoV. Because mainstream antiviral approaches such as vaccines and neutralizing …
Kimberly Frances Raab-Graham · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2022 · $335,999 — PROJECT SUMMARY Overview: The project focuses on understanding the molecular basis of how disrupted calcium homeostasis leads to disrupted hippocampal network activity that results in maladaptive responses in neurons with TSC deficient signaling. Approximately 33% of children who have autism spectru…
MARCUS AARON HORWITZ · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2022 · $549,664 — Project Summary/Abstract Francisella tularensis is a bacterium that causes tularemia, a disease which, when in its pneumonic form, can be fatal even with appropriate treatment. Due to its low infectious dose, ease of spread by aerosol, and high virulence, F. tularensis is classified as a Tier 1 Sele…
CECILIA GIULIVI · UNIVERSITY OF CALIFORNIA AT DAVIS · 2022 · $439,250 — SUMMARY Carriers of the FMR1 premutation have expanded CGG repeats at the 5’ UTR of this gene. Carriers have a higher risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS), a progressive neurodegenerative disease accompanied by tremor and ataxia as well as deficits in cognition, lea…
HARRIS A GELBARD · UNIVERSITY OF ROCHESTER · 2022 · $423,500 — PROJECT SUMMARY/ABSTRACT Public/health/relevance: Chronic, or recurring, neurological deficits in 60% of recovered COVID-19 patients are now an unmet medical need to treat the aftermath of SARS-CoV-2 infection of the central nervous system (CNS). A recent study from Germany suggests that these sym…
Mahmoud Moradi · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · 2022 · $221,612 — PROJECT SUMMARY With recent advances in structural biology and supercomputing technology, all-atom molecular dynamics (MD) simulation technique has gained momentum as a prominent tool for the study of protein structural dynamics. Brute-force MD, however, is not capable of adequately sampling most fu…