Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Cynthia Ann Derdeyn · EMORY UNIVERSITY · 2021 · $223,125 — Project Summary/Abstract HIV research efforts are strongly focused on developing vaccines that can elicit highly protective antibody responses. There is evidence from human and nonhuman vaccine studies that both neutralizing and non- neutralizing antibody activities contribute to protection against …
Lanying Du · NEW YORK BLOOD CENTER · 2021 · $102,509 — Project Summary Viral subunit vaccines are safe and convenient, but generally suffer low efficacy. Our overall hypothesis is that an intrinsic limitation is associated with subunit vaccine designs in which artificially exposed surfaces of subunit vaccines contain epitopes unfavorable for vaccine eff…
Jian Xu · UT SOUTHWESTERN MEDICAL CENTER · 2021 · $441,479 — PROJECT SUMMARY There is a pressing urgency to understand the regulatory mechanisms that control the expression of ACE2, the cellular receptor for the new coronavirus SARS-CoV-2, in human cells under physiological and pathological conditions. The binding between ACE2 and the SARS-CoV-2 spike protein…
YUICHIRO Justin SUZUKI · GEORGETOWN UNIVERSITY · 2021 · $80,496 — Summary/Abstract Currently the world is suffering from the pandemics of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that uses angiotensin-converting enzyme 2 (ACE2) as a receptor to enter host cells. So far, over five million people ha…
Shana O Kelley · UNIVERSITY OF TORONTO · 2021 · $295,888 — Project Summary: The COVID-19 pandemic has highlighted the shortcomings of existing testing approaches for viral infection. Diagnosing active infections using PCR or other amplification strategies is constrained to centralized testing facilities that have limited capacity. New point-of-care molecula…
Nour Al-muhtasib · YALE UNIVERSITY · 2021 · $39,995 — The overall goal of this proposal is to investigate the role of endocannabinoid (ECB) signaling in regulating distinct cortical inhibitory synapses. Physiological brain development and function are dependent on a fine-tuned balance of synaptic excitation and inhibition. As such, dysregulation of inh…
RICK B MEEKER · UNIV OF NORTH CAROLINA CHAPEL HILL · 2021 · $388,750 — HIV infection of the nervous system results in chronic infection, inflammation and cognitive decline in many patients with no effective treatments. Inflammation appears early in the disease process and causes progressive neural damage due, in part, to factors released by activated microglia and macr…
Pamela J Bjorkman · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2021 · $2,619,302 — UNAIDS has documented millions of new HIV-1 infections every year, thus a vaccine for HIV-1 is highly desirable. To date, despite numerous efforts, no immunization regimen reproducibly elicits broadly neutralizing antibodies (bNAbs) against HIV-1. Recently available native-like HIV-1 envelope spike …
Kui Kiu Chan · ORTHOGONAL BIOLOGICS, INC. · 2021 · $95,981 — ABSTRACT The spike protein (S) of SARS coronavirus 2, the pathogen responsible for COVID-19, binds angiotensin- converting enzyme 2 (ACE2) as an entry receptor, triggering conformational changes in S that drive fusion of the viral envelope and host cell membrane. Infection is inhibited by neutraliz…
Yicheng Tu · UNIVERSITY OF SOUTH FLORIDA · 2021 · $287,698 — Project Summary We will design and develop a molecular simulation data management system, we call P2DMS, to analyze large dis- tributed molecular dynamics (MD) simulation data. The salient features of the system include: (1) a push-based local query engine design that handles data in a batch process…
Rachael Ann Clark · BRIGHAM AND WOMEN'S HOSPITAL · 2021 · $443,750 — SUMMARY COVID 19, the lower respiratory disease caused by the 2019 nCov virus, is the latest betacoronavirus to cause epidemic disease in humans. Previously, SARS and MERS, both cause by related viruses, emerged and fell dormant as epidemics. Betacoronaviruses use homologous “Spike” proteins to bind…
HUAFENG WEI · UNIVERSITY OF PENNSYLVANIA · 2021 · $332,767 — Abstract Coronavirus disease 2019 (COVID-19), a pandemic affecting millions of patients around the world, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with no effective drug treatments. Both infection and transfection of virus in host cells require abnormally elevated C…
Amit Praful Khandhar · HDT BIO CORPORATION · 2021 · $927,069 — Project Summary/Abstract A key requirement for HIV-1 vaccine development is the induction of broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope (Env) spike. The BG505 SOSIP.664 gp140 soluble timer is engineered to display conformational epitopes recognized by several bNAbs but not …
STEVEN A BENNER · FIREBIRD BIOMOLECULAR SCIENCES, LLC · 2021 · $258,854 — Reagents to Chemically Tag Specific Coronavirus Spike Proteins Firebird Biomolecular Sciences, LLC. Steven A. Benner Bharat Gawande Abstract While vaccines and antivirals may be long term solutions to the current coronavirus pandemic, it is now widely appreciated that the pandemic can be managed …
Surojit Sarkar · SEATTLE CHILDREN'S HOSPITAL · 2021 · $513,297 — ABSTRACT (COVID-19 SUPPLEMENTAL RESEARCH) During fast-spreading disease outbreaks (such as the present COVID-19 pandemic), quick induction of herd immunity through vaccination is critical. Currently there are many SARS-CoV2 candidate vaccines in various stages of clinical development, aimed at indu…
Robert N Kirchdoerfer · UNIVERSITY OF WISCONSIN-MADISON · 2021 · $92,225 — SUMMARY Coronaviruses are sporadically emerging viruses responsible for SARS and MERS disease outbreaks. There are currently no direct treatments for these viruses, nor is there a vaccine which induces broad protection from infection. However, several stages in the virus life cycle are promising ta…
MARCUS AARON HORWITZ · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2021 · $549,664 — Project Summary/Abstract Francisella tularensis is a bacterium that causes tularemia, a disease which, when in its pneumonic form, can be fatal even with appropriate treatment. Due to its low infectious dose, ease of spread by aerosol, and high virulence, F. tularensis is classified as a Tier 1 Sele…
WALTHER H MOTHES · YALE UNIVERSITY · 2021 · $848,007 — Summary The COVID19 pandemic may take 1-3 years and only fully subside once we reach herd immunity. Given the high mortality of COVID19, it is of critical importance to reach herd immunity through a vaccine. The viral spike glycoprotein (S) is central to our efforts for developing an effective vacci…
DWAYNE W GODWIN · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2021 · $429,824 — PROJECT SUMMARY Alcohol withdrawal (WD) produces a range of dangerous clinical symptoms, including intense seizures. Hyperexcitability underlying seizures is produced by an array of intrinsic membrane properties that are disrupted by ethanol (EtOH). Prior work has demonstrated that chronic EtOH expo…
Kenneth L Shepard · QUICKSILVER BIOSCIENCES, INC. · 2021 · $817,335 — Direct bioelectronic detection of SARS-CoV-2 from saliva using single-molecule field-effect transistor array Nucleic acid tests have become the gold-standard for diagnostic testing for COVID-19, usually performed in specialized laboratories. Most are based on reverse-transcription quantitative pol…