Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Jane R Taylor · YALE UNIVERSITY · 2021 · $330,750 — Drug-associated conditioned stimuli (CS), or cues, contribute to both the progression and persistence of addiction. We hypothesize, as have others, that blocking reconsolidation of cocaine-cue memories could prevent cue-induced relapse. Reconsolidation is a process whereby reactivation of a memory r…
Jae U Jung · CLEVELAND CLINIC LERNER COM-CWRU · 2021 · $519,707 — Project Summary/Abstract The massive outbreak of newly emerged coronavirus disease 2019 (COVID-19) has been rapidly spread worldwide, leading to a pandemic infection and serious global health emergency. In order to prevent further dissemination of severe acute respiratory syndrome coronavirus 2 (SA…
Margaret Juliana McElrath · FRED HUTCHINSON CANCER RESEARCH CENTER · 2021 · $14,980,054 — Project Abstract This proposal outlines the scientific agenda for the COVID-19 Prevention Network (CoVPN) Vaccines Leadership Operations Center (LOC) for implementation of the COVID-19 vaccine efficacy trial entitled “A Phase 3, Randomized, Observer-Blinded, Placebo-Controlled Study to Evaluate the …
Betty Diamond · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · 2021 · $196,504 — Abstract There are mechanisms in the brain that regulate interactions between neurons and microglial cells and promote homeostasis. These are perturbed in several diseases including neuropsychiatric lupus, NPSLE, studied in this PPG, and following sepsis. Many conditions of neuroinflammation are cha…
Rebecca Powell · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $668,126 — Project Summary SARS-CoV-2, commonly termed COVID-19 for the illness it causes, has infected >4.1 million people, including >240,000 deaths. Though COVID-19 pathology in children is believed to be relatively mild compared to adults, approximately 10% of infants experience severe COVID-19 illness re…
Leila Aminova · MIDWEST BIOPROCESSING CENTER, LLC · 2021 · $982,971 — SUMMARY The goal of this project is to develop novel methods to produce sugar building blocks, oligosaccharides, and glycans needed to support and grow R&D related to viral glycobiology at large scale and reasonable prices. This technology will support researchers studying viral pathology, analyses…
Suzie H. Pun · UNIVERSITY OF WASHINGTON · 2021 · $466,500 — PROJECT SUMMARY The SARS-CoV-2 coronavirus, the cause of the COVID-19 global pandemic, is efficiently spread and has reached over 27 million confirmed cases as of September 8, 2020. There is therefore an urgent need for new technologies that can provide early detection of virus, reducing the transmi…
Ly James Lee · OHIO STATE UNIVERSITY · 2021 · $900,019 — Abstract The World Health Organization has recognized a global pandemic of novel coronavirus pneumonia (COVID-19) from exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronaviruses (CoVs) are membrane-enveloped positive-sense, single-stranded RNA viruses decorated with …
Jim Rotolo · SAPIENCE THERAPEUTICS, INC. · 2021 · $299,860 — ABSTRACT The COVID-19 pandemic, caused by the SARS-CoV-2 virus, is a serious threat to global public health, necessitating the rapid development of safe and effective medical countermeasures. SARS-CoV-2 pathogenicity requires a series of protein-protein interactions (PPI) involving the virus’ S prot…
JEFFREY J DESTEFANO · UNIV OF MARYLAND, COLLEGE PARK · 2021 · $231,750 — The impact of SARS-CoV-2 on public health and the global economy cannot be overstated. As of September 28, 2020, 33,224,222 cases and 999,298 deaths worldwide have been linked to this emergent virus. This staggering number continues to grow, with the United States baring disproportionately high rate…
Daniel Kulp · WISTAR INSTITUTE · 2021 · $274,544 — Project Summary This revised application was originally responding to the Emergency Award ‘Rapid Investigation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19)’ submitted through PAR-20-177. However, we are submitting the revised application, up…
Emanuela Marina Bruscia · YALE UNIVERSITY · 2021 · $663,843 — PROJECT SUMMARY Macrophages (MΦs) kill microorganisms, engulf dead cells and debris, and regulate the immune response. They are thus gatekeepers of tissue health, including the lungs. The lung-tissue-resident MΦs (TR-MΦs) are the interstitial and alveolar MΦs, which have complementary but distinct f…
Houjian Cai · UNIVERSITY OF GEORGIA · 2021 · $226,500 — Summary/Abstract SARS-CoV-2 has infected over 51 million and is responsible for the death of over 1.27 million people globally. Interventions to address both prevention and treatment are urgently needed. Infection of SARS-CoV- 2 requires the host serine protease TMPRSS2 to activate the virus spike p…
Judith S. Currier · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2021 · $19,807,516 — Abstract A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Assessing the Efficacy and Safety of Anti-Spike SARS-CoV-2 Monoclonal Antibodies in Preventing SARS-Cov-2 Infection in Household Contacts of Individuals Infected with SARS-CoV-2 (CoVPN 3502) Transmission of SARS-CoV-2 occurs pri…
Peter B. Gilbert · FRED HUTCHINSON CANCER RESEARCH CENTER · 2021 · $18,322,345 — Project Abstract This proposal outlines the scientific agenda for the COVID-19 Prevention Network (CoVPN) Vaccines Leadership Operations Center (LOC) for implementation of the COVID-19 vaccine efficacy trial entitled “A Randomized, Double-blind, Placebo-controlled Phase 3 Study to Assess the Efficac…
DARRICK Albert CARTER · PAI LIFE SCIENCES, INC. · 2021 · $243,000 — PROJECT SUMMARY Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in late 2019 causing Coronavirus Disease 2019 (COVID-19) and within months became a worldwide pandemic - as of the writing of this proposal, at least 82.5M people have been infected and more than 1.8M have died in a…
Paras Patel · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2021 · $39,800 — PROJECT SUMMARY Understanding how different regions of the central nervous system (CNS) are affected by genetic insults is critical to advancing the study of CNS pathologies which present a major public health burden in the United States. The cerebellum and optic nerve are two such regions that are …
Anne Moscona · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2021 · $773,390 — No vaccines or treatments for SARS-CoV-2 are yet available. A simple prophylactic antiviral strategy would protect naïve individuals from infection now. In the future, when vaccines should be available, a prophylactic antiviral will be essential for individuals who do not mount a suitable immune res…
Michel C Nussenzweig · ROCKEFELLER UNIVERSITY · 2021 · $458,301 — The WHO and US authorities have declared a public health emergency over the recent outbreak of a new coronavirus (CoV) originating from Wuhan, China (nCoV-2019, recently renamed SARS-CoV-2 and responsible for causing the coronavirus disease termed COVID-2019). The discovery of human monoclonal antib…
Hongpeng Jia · JOHNS HOPKINS UNIVERSITY · 2021 · $202,068 — Summary of the Funded Parent Grant (1R21AI149321-01, 01/01/2020 - 12/31/2021) Pneumonia and associated inflammatory lung diseases (ILD) are a leading cause of death among children and elderly worldwide and a significant source of morbidity and mortality among hospitalized patients. Interestingly, th…