Appendix: Lighthouse change stories, solutions and impact Site Change story Top five use cases Impact AstraZeneca Södertälje, SwedenTo boost capacity and accelerate product launches, AstraZeneca Södertälje implemented 50+ 4IR solutions, including machine learning and optimization algorithms. These efforts, coupled with the upskilling of 3,000 employees, resulted in a 56% increase in labour productivity and a 67% reduction in development lead times for new productsMachine Learning (ML) demand forecasting engine 23% Inventory level Mathematical optimization for batch scheduling and production planning 26% Productivity Advanced process control for new product development and launch 98%Continuous manufacturing cycle time Process digital twins for batch manufacturing optimization 17%Batch manufacturing cycle time Forecasting for the clinical phase of NPI 39% Overproduction rate AstraZeneca Wuxi, People’s Republic of ChinaResponding to domestic price cuts and increased demand volatility, AstraZeneca Wuxi deployed 34 4IR use cases, including AI and algorithms, to enhance manufacturing synchronization and efficiency. The site achieved a 55% increase in output, a 44% reduction in manufacturing lead time, an 80% reduction in non-perfect batches and a 54% improvement in labour productivity.Synchronized factory flow enabled by batch priority optimization 48% Process lead time IoT enabled end-to-end touchless material flow and traceability 99%Material dispensing lead-time Deep learning enabled high-speed computer vision for in-process quality control 99.4% Rework hours IoT based smart andon improves manpower and equipment utilization 31% Unplanned down time ML-enabled forecast engine & inventory control tower 42%Raw material Inventory days Beko Ankara, TürkiyeTo meet the rising demand for high- quality dishwashers, Beko Dishwasher Plant underwent a 4IR transformation by integrating 35+ in-house solutions with its IoT platform, FLOW. This led to a 46% reduction in time-to-market, a 29.2% drop in field failure rates, and a 26.1% decrease in conversion costs. Additionally, over 1,000 employees were upskilled in 4IR technologies.ML-powered smart metal sheet forming 12.5% Material cost Advanced cleaning cycle design 50% Time to market AI-enhanced clinching process 66% Defect rate End-to-end autonomous intra-logistic system 5% Conversion cost Supplier collaboration for the advanced plastic injection 98.5% Defect rateFactory Lighthouses Wave 12 Global Lighthouse Network: The Mindset Shifts Driving Impact and Scale in Digital Transformation 35

Global Lighthouse Network 2025