01 Loehr mening 508

CDC ACIP — Vaccine Advisory Committee

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Introduction to Meningococcal Vaccines 
Session
Jamie Loehr, MD
Advisory Committee on Immunization Practices
April 16, 2025National Center for Immunization & Respiratory Diseases
1
3 Terms of Reference
GSK Pentavalent (MenABCWY) Vaccine
MenQuadfi Use in Infants
Adolescent Schedule Change
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3 Terms of Reference
GSK Pentavalent (MenABCWY) Vaccine
–Licensure:  February 14, 2025
–ACIP Vote:  April 16, 2025 (today)
MenQuadfi Use in Infants
–Licensure:  May 2025 (anticipated)
–ACIP Vote:  June 2025 (anticipated)
Adolescent Schedule Change
–WG deliberations ongoing
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Today
GSK Pentavalent (MenABCWY) Vaccine:  Update of EtR and 
Work Group Considerations
Updates to Meningococcal Vaccines VFC Resolution
Introduction to MenQuadfi Label Change for Infants
MenQuadfi in Infants:  Safety and Immunogenicity
Work Group Considerations Regarding MenQuadfi in Infants
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Today
GSK Pentavalent (MenABCWY) Vaccine:  Update of EtR and 
Work Group Considerations
Updates to Meningococcal Vaccines VFC Resolution
–VOTE (including VFC Vote)
Introduction to MenQuadfi Label Change for Infants
MenQuadfi in Infants:  Safety and Immunogenicity
Work Group Considerations Regarding MenQuadfi in Infants
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GSK Pentavalent Vaccine
After immunogenicity data presented to ACIP , Bexsero 
(comparator) label changed from 0, ≥1 month to 0, 6 months 
Longer intervals between vaccine doses associated with higher immunogenicity
–As a result, pentavalent now has comparatively lower 
immunogenicity than MenB
Some data points in label have also been updated
WG members voiced need for ACIP to review updated data in 
consideration of vote, although WG recommendation has not changed
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ACIP Meningococcal Vaccines Work Group 
ACIP Members on the WG
 Jamie Loehr (Chair)
 Charlotte Moser
Ex Officio WG Members
 Margaret Bash (FDA)
 Xin-Xing Gu (NIH)
7 of 8WG Liaisons and Consultants
 Amra Resic (AAFP)
 Mary Healy (AAP) 
 Barb Fluty (ACHA)
 Karyn Lyons (AIM)
 Stephanie Schauer (AIM)
 Paul Cieslak (CSTE)
 Kathy Hsu (IDSA)
 Joseline Zafack (NACI)
 Jeff Goad (NFID)
 Jessica Cataldi (PIDS)
 Amy Middleman (SAHM)
 Kathy Poehling (Wake Forest)
 Lynn Bahta (Minnesota Department of Health)
 David Stephens (Emory)
Acknowledgements 
CDC Contributors
 Sarah Schillie (DBD/NCIRD) – Meningococcal Lead
 Jennifer Collins (DBD/NCIRD) – Hib Lead
 Lucy McNamara (DBD/NCIRD)
 Avnika Amin (DBD/NCIRD)
 LeAnne Fox (DBD/NCIRD)
 Susan Hariri (DBD/NCIRD)
 Amy Rubis (DBD/NCIRD)
 Jenny Thomas (DBD/NCIRD)
 Noele Nelson (DBD/NCIRD)
 Alison Albert (DBD/NCIRD)
 Shelby Miller (DBD/NCIRD)
 Michael Williams (DBD/NCIRD)
 Michelle Hughes (DBD/NCIRD)
 Madhura Vachon (DBD/NCIRD)
 Gabrielle Cooper (DBD/NCIRD)
 Xiaoyu Dong (ISD/NCIRD)
 Andrew Leidner (ISD/NCIRD)
 Katherine Lean (DBD/NCIRD)
 Ismael Ortega- Sanchez (CORVD/NCIRD)
 Jonathan Duffy (DHQP/NCEZID)
 Pedro Moro (DHQP/NCEZID)
 Tanya Myers (DHQP/NCEZID) 
 Madeleine Valier (ISD/NCIRD)
 Sam Graitcer (ISD/NCIRD)
 Leslie Lee (OD/NCIRD)
 Manisha (Mo) Patel (OD/NCIRD)
 Jessica MacNeil (ACIP Secretariat)
 Hannah Rosenblum (ACIP Secretariat)
 Melinda Wharton (ACIP Secretariat)
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