The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury

Document text

Principal Investigator: CRAIG J. MCCLAIN
Organization: UNIVERSITY OF LOUISVILLE
Fiscal Year: 2024
Award: $1,357,495
Funding agency: National Institute on Alcohol Abuse and Alcoholism

The University of Louisville Alcohol Research Center (ULARC) was created to serve as a
regional/national resource to perform interdisciplinary collaborative research on the role of nutrition as
a cofactor in alcohol induced organ injury and as a possible therapeutic intervention to prevent/treat
this organ injury. The nutrition and alcohol-induced organ injury theme of the center is unique among
alcohol centers. The approach is highly translational. Our investigators include faculty from 13 departments
and 6 colleges. The Specific Aims of the ULARC are to:
1) perform/facilitate interdisciplinary research on nutrition and alcohol-induced organ injury;
2) serve as a regional/national resource for the study of nutrition and alcohol-induced organ injury;
3) develop potential therapeutic targets/interventions for alcohol induced organ injury based on the
mechanistic research of the ULARC; and
4) disseminate knowledge/interventions to the scientific and lay communities.
We will explore interactions of nutrition and alcohol abuse in the development of alcohol-induced organ
dysfunction, and we will evaluate diverse potential nutritional preventive/therapeutic interventions. Project 1
(Kirpich/McClain) evaluates the role of dietary fat in ALD pathogenesis; Project 2 (Barve) evaluates alcohol-
induced epigenetic alterations in the gut:liver axis. Project 3 (Chen) will elucidate the mechanisms by which
enhancers mediate ethanol-induced developmental impairment of neural crest cells and teratogenesis and
unique exosome treatment for prevention of FASD. Project 4 (Feng) studies the beneficial effects of the
probiotic, Lactobacillus rhamnosis GG (LGG)on the gut:liver axis in ALD.
 Together, these projects form a cohesive and interactive approach to investigate the effects of nutrition and
nutritional interventions on alcohol-induced organ injury.

Terms: <Absolute ethanol><Alcohol Chemical Class><Alcohol abuse><Alcoholic Liver Diseases><Alcohols><Approaches to prevention><Brain><Brain Nervous System><Broccoli><Broccoli - dietary><Butyrates><Cause of Death><Cell Communication and Signaling><Cell Signaling><Chronic><Collaborations><Communities><Country><Development><Dietary Fats><Dietary Intervention><Dysfunction><ETOH><Education><Educational aspects><Encephalon><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><EtOH abuse><Ethanol><Ethyl Alcohol><FASD><FDA approved><Faculty><Feces><Fetal Alcohol Spectrum Disorder><Fetal Alcohol Syndrome><Fostering><Functional disorder><Funding><Future><Goals><Grain Alcohol><Grant><Health><Health Care Costs><Health Costs><Healthcare Costs><Impairment><Individual><Industry><Injury><Institution><Interdisciplinary Research><Interdisciplinary Study><Intervention><Intervention Strategies><Intestinal><Intestines><Intracellular Communication and Signaling><Investigators><Knowledge><Lactobacillus><Lipids><Mediating><Mediator><Methylcarbinol><Morbidity><Morbidity - disease rate><Multidisciplinary Collaboration><Multidisciplinary Research><NIAAA><NIH><National Institute on Alcohol Abuse and Alcoholism><National Institutes of Health><Neural Crest Cell><Nutrition Interventions><Nutritional><Nutritional Interventions><Organ><Pathogenesis><Physiopathology><Prevention><Prevention approach><Preventive><Probiotics><Productivity><Proteomics><Research><Research Personnel><Research Resources><Researchers><Resources><Role><School Dentistries><School Dentistry><Short-Chain Fatty Acids><Signal Transduction><Signal Transduction Systems><Signaling><Sulfaforaphane><Sulforaphane><Therapeutic Intervention><United States><United States National Institutes of Health><Universities><Volatile Fatty Acids><alcohol abuse therapy><alcohol abuse treatment><alcohol co-abuse><alcohol exposed><alcohol exposure><alcohol induced hepatic injury><alcohol induced liver disorder><alcohol induced liver injury><alcohol intervention><alcohol problem><alcohol related liver disease><alcohol related research><alcohol research><alcohol treatment><alcohol use disorder><alcohol-associated liver disease><alcohol-induced hepatic dysfunction><alcohol-induced liver disease><alcohol-induced liver dysfunction><alcohol-mediated liver dysfunction><alcohol-mediated liver injury><alcohol-related liver disease><alcoholic embryopathy><alcoholic liver injury><bacteria in the gut><base><bases><biological signal transduction><bowel><bowel inflammation><broccoli sprout><cofactor><college><collegiate><developmental><diet intervention><dietary lipid><embryofetal alcohol syndrome><embryopathia alcoholica><epigenetically><ethanol abuse><ethanol exposed><ethanol exposure><ethanol induced hepatic injury><ethanol induced liver disorder><ethanol induced liver injury><ethanol liver disease><ethanol research><ethanol use disorder><ethanol-induced hepatic dysfunction><ethanol-induced liver disease><ethanol-induced liver dysfunction><ethanol-mediated liver dysfunction><ethanol-mediated liver injury><exosome><exposed to alcohol><exposed to ethanol><exposure to alcohol><exposure to ethanol><gut bacteria><gut inflammation><gut-liver axis><hazardous alcohol use><hepatic inflammation><high school><improved><inflamed bowel><inflamed gut><inflamed intestine><inflamed liver><injuries><injury to organs><intervention therapy><interventional strategy><intestinal barrier><intestinal inflammation><intestinal mucosal barrier><liver inflammation><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><methylsulfoxybutylisothiocyanate><mortality><mouse model><multidisciplinary><murine model><nano particle><nano-sized particle><nanoparticle><nanosized particle><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><nutrition><nutritious><organ injury><pathophysiology><prevent><preventing><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><social role><stool><sulforafan><sulforophane><teratogenesis><therapeutic effectiveness><therapeutic target>