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Principal Investigator: Hao Gong
Organization: MAYO CLINIC ROCHESTER
Fiscal Year: 2024
Award: $212,507
Funding agency: National Institute of Arthritis and Musculoskeletal and Skin Diseases
PROJECT SUMMARY/ABSTRACT
Around 80 million US adults will have arthritis by 2040, which causes a significant societal problem resulting
in an annual healthcare cost of > $136.8 billion. These progressive degenerative diseases result in long-term
functional disabilities and morbidities leading to activity limitations and productivity loss. Joint instability
typically precedes before the symptom onset, but it is typically not detectable in standard imaging exams.
Patients can therefore suffer for years, as symptoms worsen before an accurate diagnosis is made. There is a
critical need for an accurate imaging technique for early diagnosis, which is crucial to providing the most
effective medications, therapies, and surgical interventions and restoring joint function before the onset of
disabling symptoms.
Various limitations have hindered the accurate detection of joint instability in standard imaging exams:
radiography and fluoroscopy cannot visualize 3-dimensional (3D) joint anatomy; ultrasound lacks
visualization of bone structure; static MRI/CT cannot assess the effect of dynamic structural and
biomechanical pathologies. Accurate diagnosis is therefore oftentimes acquired using invasive arthroscopy,
which exposes patients to risks of the associated complications. Although there have been some recent
advancements in 4D (3D + time) CT to provide dynamic imaging capability, its clinical use is limited due to
(1) joint motion artifacts that affect accurate anatomical and functional analyses, and (2) poor soft-tissue
visualization that prohibits robust assessment of connective tissue involvement.
The specific goal of this application is to develop and validate a new diagnostic imaging technique – 6DCT (3D
+ time + spectral information + kinematics) in combination with custom deep-learning methods. The 6DCT will
provide an accurate, informative, one-stop-shop diagnostic tool to assess early dynamic joint pathologies
before the onset of arthritis, which will obviate the need for invasive tests and procedures, with improved
patient care and associated cost savings. We will accomplish this goal through three specific aims:
1. Develop a robust motion correction technique for dynamic joint imaging.
2. Develop a spectral post-processing technique for characterizing connective tissue involvement.
3. Demonstrate the feasibility of 6DCT in imaging dynamic joint pathology.
This work is the first to develop innovative 6DCT as a robust dynamic imaging tool for both bone and connective
tissues, and to provide new anatomical and functional information to facilitate assessing dynamic joint pathologies.
These capabilities have clinical significance as they will enable early diagnosis of joint instability, which will
subsequently enable early interventions that will improve patient health. This proposal will develop the
essential techniques and preliminary data for future large cohort prospective patient studies.
Terms: <21+ years old><3-D><3-D visualization><3-Dimensional><3-dimensional visualization><3D><3D visualization><4-dimensional computed tomography><4DCT><Address><Adult><Adult Human><Affect><Anatomic Sites><Anatomic structures><Anatomy><Anxiety><Arthritis><Arthroscopy><Artifacts><Attention><Biomechanics><Bone Tissue><Bone structure><CAT scan><CT X Ray><CT Xray><CT imaging><CT scan><Cadaver><Carpometacarpal Joint><Carpometacarpal joint structure><Cartilage><Cartilaginous Tissue><Clinical><Code><Coding System><Collagen><Color><Computed Tomography><Connectionist Models><Connective Tissue><Cost Savings><Custom><Data><Degenerative Disorder><Detection><Development><Diagnosis><Diagnostic Imaging><Disease><Disorder><Distal><Drugs><Early Diagnosis><Early Intervention><Fluoroscopy><Functional impairment><Future><Goals><Hand><Health><Health Care Costs><Health Costs><Healthcare Costs><Image><Imaging Device><Imaging Instrument><Imaging Procedures><Imaging Technics><Imaging Techniques><Imaging Tool><Intervention><Intervention Strategies><Joint Diseases><Joint Instability><Joints><Lead><Learning><Ligaments><Logistic Regressions><Long term disability><MR Imaging><MR Tomography><MRI><MRI Scans><MRIs><Magnetic Resonance Imaging><Magnetic Resonance Imaging Scan><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Membrum superius><Mental Depression><Methods><Morbidity><Morbidity - disease rate><Morphologic artifacts><Motion><NMR Imaging><NMR Tomography><Neural Network Models><Neural Network Simulation><Nuclear Magnetic Resonance Imaging><Operative Procedures><Operative Surgical Procedures><Pain><Painful><Pathology><Patient Care><Patient Care Delivery><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Perceptrons><Pharmaceutical Preparations><Phase><Physics><Procedures><Prospective Studies><Prospective cohort><Radiography><Reader><Reporting><Research Specimen><Risk><Roentgenography><Scanning><Source><Specimen><Surgical><Surgical Interventions><Surgical Procedure><Symptoms><Techniques><Tendon structure><Tendons><Testing><Thick><Thickness><Thumb><Thumb structure><Time><Tomodensitometry><Training><Upper Extremity><Upper Limb><Visualization><Work><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><Zeugmatography><accurate diagnosis><adulthood><arthritic><arthropathic><arthropathies><arthropathy><base><bases><biomechanical><bone><bone imaging><bone scanning><bone visualization><cadaveric><cadavers><cardiac motion><care for patients><care of patients><caring for patients><cartilage degeneration><cartilage degradation><catscan><clinical significance><clinically significant><computed axial tomography><computer tomography><computerized axial tomography><computerized tomography><customs><data library><deep learning><deep learning method><deep learning strategy><degenerative condition><degenerative disease><density><depression><developmental><diagnostic tool><disabling symptom><drug/agent><early detection><experience><four-dimensional computed tomography><functional disability><hands><heart motion><heavy metal Pb><heavy metal lead><image-based method><imaging><imaging capabilities><imaging method><imaging modality><improved><innovate><innovation><innovative><interventional strategy><joint damage><joint disorder><joint function><joint injury><joint trauma><kinematic model><kinematics><new diagnostics><next generation diagnostics><non-contrast CT><noncontrast CT><noncontrast computed tomography><novel><novel diagnostics><patient oriented outcomes><productivity loss><radiologic imaging><radiological imaging><skeletal imaging><skeletal structure><skeletal visualization><societal costs><soft tissue><surgery><synergism><temporal measurement><temporal resolution><three dimensional><three-dimensional visualization><time measurement><ultrasound><vector><virtual>