Document text
Principal Investigator: Jonathan B Overdevest
Organization: COLUMBIA UNIVERSITY HEALTH SCIENCES
Fiscal Year: 2023
Award: $178,610
Funding agency: National Institute on Deafness and Other Communication Disorders
PROJECT SUMMARY
Smell loss is a common neurosensory disability accompanying infection with SARS-CoV-2 novel coronavirus.
The frequency and persistence of alteration in the ability to smell, or olfactory dysfunction (OD), observed
during the COVID-19 pandemic highlight a knowledge gap, where risk factors predicting post-viral OD and
subsequent neurological dysfunction remain poorly understood. This K23 proposal will characterize
epidemiological risk factors associated with OD following COVID-19 infections, which in turn may signify risk
for neurocognitive and neuropsychological impairment in daily functioning and quality of life. As a career
development award, this proposal will provide Dr. Jonathan Overdevest, MD, PhD, an Assistant Professor in
the Department of Otolaryngology-Head and Neck Surgery at Columbia University Irving Medical Center
(CUIMC) with structured training to establish an independent career in the study of olfactory dysfunction and
neurocognition. Under the guidance of his primary mentor, D.P. Devanand, and an experienced team of
experts, Dr. Overdevest will develop domain expertise in the design and analysis of chemosensory-focused
neuroepidemiologic studies using patient-oriented research (POR) methodology. Building upon preliminary
data evaluating prevalence and persistence of OD in a vulnerable minority population served by CUIMC, Dr.
Overdevest will develop the framework for a longitudinal cohort study within this multi-ethnic population. The
research in Aim 1 will investigate epidemiologic risk factors for primary and persistent OD following COVID-19
infection by evaluating OD with subjective functional domain and test-based objective tools. In Aim 2, he will
study the relationship between persistent OD and neurological, neurocognitive, and neuropsychiatric
functioning using validated measures from the multilingual NIH Toolbox assessment battery. He will then
extend this preliminary work into the realm of neuroimaging by leveraging existing local research infrastructure
and the expertise of his mentorship team to develop pilot data correlating features of OD and neurologic
outcomes with anatomic and inflammatory changes in the brain. These studies will inform strategies for
counseling the public about demographic risk factors for experiencing COVID-19 related OD, associate risks
for additional neurological disabilities, and provide the foundation for future investigation into imaging
modalities to evaluate the central processing of olfaction and monitor outcomes of clinical trials for OD
interventions.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><65+ years old><AD dementia><Address><Affect><Aged 65 and Over><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Anatomic Sites><Anatomic structures><Anatomy><Anosmia><Apoplexy><Autoimmune Diseases><Awareness><Biological Markers><Brain><Brain Inflammation><Brain Nervous System><Brain Vascular Accident><COVID><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 affected><COVID-19 consequence><COVID-19 crisis><COVID-19 effect><COVID-19 epidemic><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 impact><COVID-19 impacted><COVID-19 infection><COVID-19 pandemic><COVID-19 predisposition><COVID-19 public health crisis><COVID-19 related risk><COVID-19 risk><COVID-19 risk factor><COVID-19 susceptibility><COVID-19 virus><COVID-19 virus infection><COVID-19 vulnerability><COVID19><COVID19 crisis><COVID19 epidemic><COVID19 global health crisis><COVID19 global pandemic><COVID19 health crisis><COVID19 infection><COVID19 pandemic><COVID19 public health crisis><COVID19 virus><CV-19><CV19><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Cephalalgia><Cephalgia><Cephalodynia><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Chemicals><Clinical><Clinical Trials><CoV disease><CoV emergence><CoV-2><CoV2><Cognitive Discrimination><Cohort Studies><Competence><Concurrent Studies><Coronavirus disease 2019 predisposition><Coronavirus disease 2019 susceptibility><Coronavirus disease 2019 vulnerability><Counseling><Cranial Pain><Cross Sectional Analysis><Cross-Sectional Analyses><Cross-Sectional Studies><Cross-Sectional Survey><Data><Data Analyses><Data Analysis><Data Base Management><Data Base Management Systems><Data Correlations><Database Management Systems><Degenerative Neurologic Diseases><Degenerative Neurologic Disorders><Demographic Factors><Development><Diabetes Mellitus><Disabled Persons><Disabled Population><Discrimination><Disease Frequency Surveys><Dizziness><Doctor of Philosophy><Dysfunction><Encephalitis><Encephalon><Entorhinal Area><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology><Epidemiology Research><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Evaluation><Fatigue><Foundations><Frequencies><Functional disorder><Future><Goals><Groups at risk><Gustation><Handicapped><Head Pain><Head and Neck Surgery><Headache><High Prevalence><Hospitals><Immune response><Immunological response><Impairment><Individual><Infection><Inflammatory><Intervention><Intervention Strategies><Investigation><K-Awards><K-Series Research Career Programs><Knowledge><Lack of Energy><Learning><Long-term cohort study><Longitudinal Studies><Longitudinal cohort study><Longterm cohort study><MDS-UPDRS><MDS-Unified Parkinson's Disease Rating Scale><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medical center><Memory><Mentors><Mentorship><Minority Groups><Minority People><Minority Population><Minority individual><Mission><Modality><Monitor><Movement Disorder Society Unified Parkinson's Disease Rating Scale><Multilingualism><NIDCD><NIH><NMR Imaging><NMR Tomography><Nasopharynx><National Institute on Deafness and Other Communication Disorders><National Institutes of Health><Nervous System Degenerative Diseases><Nervous System Physiology><Neural Degenerative Diseases><Neural degenerative Disorders><Neuro-epidemiology><Neurocognition><Neurocognitive><Neurodegenerative Diseases><Neurodegenerative Disorders><Neuroepidemiology><Neurologic><Neurologic Degenerative Conditions><Neurologic Dysfunctions><Neurologic function><Neurologic outcome><Neurological><Neurological function><Neurological outcome><Neuropsychologies><Neuropsychology><New York><Nuclear Magnetic Resonance Imaging><Obesity><Olfaction><Olfactory Pathways><Olfactory dysfunction><Olfactory system><Otolaryngology><Outcome><PET><PET Scan><PET imaging><PETSCAN><PETT><Pathology><Patients><People at risk><People with Disabilities><Perception><Persons at risk><Persons with Disabilities><Ph.D.><PhD><Physicians><Physiopathology><Pilot Projects><Population><Populations at Risk><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Predictive Factor><Predisposed to COVID-19><Predisposed to SARS-CoV-2><Predisposed to Severe acute respiratory syndrome coronavirus 2><Presbyterian Church><Presbyterians><Prevalence><Preventative intervention><Primary Senile Degenerative Dementia><QOL><Quality of life><Rad.-PET><Recovery><Research><Research Career Program><Research Design><Research Infrastructure><Research Methodology><Research Methods><Rhinopharynx><Risk><Risk Factors><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 infection><SARS-CoV-2 pandemic><SARS-CoV-2 predisposition><SARS-CoV-2 susceptibility><SARS-CoV-2 vulnerability><SARS-CoV2><SARS-CoV2 epidemic><SARS-CoV2 infection><SARS-CoV2 pandemic><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Seizures><Sensory><Sensory Disorders><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 pandemic><Severe acute respiratory syndrome coronavirus 2 predisposition><Severe acute respiratory syndrome coronavirus 2 susceptibility><Severe acute respiratory syndrome coronavirus 2 vulnerability><Severe acute respiratory syndrome related corona virus 2><Severities><Smell><Smell Perception><Strategic Planning><Stroke><Structure><Study Type><Symptoms><Taste><Taste Perception><Testing><Thick><Thickness><Training><UPDRS><Unified Parkinson's Disease Rating Scale><United States><United States National Institutes of Health><Universities><Viral><Viral Diseases><Virus><Virus Diseases><Vulnerable Populations><Work><Wuhan coronavirus><Zeugmatography><adiposity><after COVID-19 infection><after SARS-CoV-2 infection><after SARS-CoV2 infection><after infection by SARS-CoV-2><after severe acute respiratory distress syndrome CoV-2 infection><age 65 and greater><age 65 and older><aged 65 and greater><aged ≥65><anosphrasia><autoimmune condition><autoimmune disorder><autoimmunity disease><bio-markers><biologic marker><biomarker><brain attack><brain circuitry><career><cerebral vascular accident><cerebrovascular accident><co-morbid><co-morbidity><cohort><comorbidity><computer based prediction><corona virus disease><corona virus disease 2019><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><corona virus emergence><coronavirus disease><coronavirus disease 2019><coronavirus disease 2019 consequence><coronavirus disease 2019 crisis><coronavirus disease 2019 effect><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 impact><coronavirus disease 2019 infection><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease 2019 risk><coronavirus disease 2019 risk factor><coronavirus disease 2019 virus><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 impact><coronavirus disease-19 pandemic><coronavirus disease-19 virus><coronavirus emergence><coronavirus infectious disease-19><corpulence><daily functioning><data interpretation><database management><database systems><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><developmental><diabetes><disability><disabled><disabled individual><disabled people><emergent CoV><emergent corona virus><emergent coronavirus><emerging CoV><emerging corona virus><emerging coronavirus><entorhinal cortex><epidemiologic><epidemiologic investigation><epidemiological><epidemiology study><ethnic subgroup><ethnicity group><experience><following COVID-19 infection><following SARS-CoV-2 infection><following SARS-CoV2 infection><following infection by SARS-CoV-2><following severe acute respiratory distress syndrome CoV-2 infection><functional outcomes><gustatory perception><gustatory processing><gustatory response><hCoV19><head ache><host response><human old age (65+)><image-based method><imaging method><imaging modality><immune system response><immunoresponse><improved><individuals with disabilities><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><infection rate><intervention for prevention><interventional strategy><long-term study><longitudinal outcome studies><longterm study><loss of smell><multi-ethnic><multiethnic><multilingual><nCoV><nCoV2><nasopharnygeal><nervous system function><neural circuit><neural circuitry><neural imaging><neuro-imaging><neuro-sensory><neurocircuitry><neurodegenerative illness><neuroimaging><neurological dysfunction><neurological imaging><neuropsychiatric><neuropsychiatry><neuropsychologic><neurosensory><new CoV><new corona virus><new coronavirus><novel CoV><novel corona virus><novel coronavirus><odor perception><old age><olfactory bulb><olfactory circuitry><olfactory circuits><olfactory impairment><olfactory loss><olfactory perception><otorhinolaryngology><pathophysiology><patient oriented research><patient oriented study><pilot study><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><post SARS-CoV-2 infection><prediction model><predictive modeling><predisposed to Coronavirus disease 2019><prevention intervention><preventional intervention strategy><preventive intervention><previous COVID-19 infection><previous SARS-CoV-2 infection><previous SARS-CoV2 infection><previous severe acute respiratory distress syndrome CoV-2 infection><primary degenerative dementia><prior COVID-19 infection><prior SARS-CoV-2 infection><prior SARS-CoV2 infection><prior severe acute respiratory distress syndrome CoV-2 infection><professor><programs><public health relevance><rate of infection><recruit><relational database management systems><research and methods><risk associated with COVID-19><risk factor associated with COVID-19><risk factor related to COVID-19><risk related to COVID-19><senile dementia of the Alzheimer type><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><stroked><strokes><study design><susceptible to COVID-19><susceptible to Coronavirus disease 2019><susceptible to SARS-CoV-2><susceptible to Severe acute respiratory syndrome coronavirus 2><synaptic circuit><synaptic circuitry><taste processing><taste response><tool><viral infection><virus infection><virus-induced disease><vulnerable group><vulnerable individual><vulnerable people>