Document text
Principal Investigator: Jonathan B Overdevest
Organization: COLUMBIA UNIVERSITY HEALTH SCIENCES
Fiscal Year: 2024
Award: $178,610
Funding agency: National Institute on Deafness and Other Communication Disorders
PROJECT SUMMARY
Smell loss is a common neurosensory disability accompanying infection with SARS-CoV-2 novel coronavirus.
The frequency and persistence of alteration in the ability to smell, or olfactory dysfunction (OD), observed
during the COVID-19 pandemic highlight a knowledge gap, where risk factors predicting post-viral OD and
subsequent neurological dysfunction remain poorly understood. This K23 proposal will characterize
epidemiological risk factors associated with OD following COVID-19 infections, which in turn may signify risk
for neurocognitive and neuropsychological impairment in daily functioning and quality of life. As a career
development award, this proposal will provide Dr. Jonathan Overdevest, MD, PhD, an Assistant Professor in
the Department of Otolaryngology-Head and Neck Surgery at Columbia University Irving Medical Center
(CUIMC) with structured training to establish an independent career in the study of olfactory dysfunction and
neurocognition. Under the guidance of his primary mentor, D.P. Devanand, and an experienced team of
experts, Dr. Overdevest will develop domain expertise in the design and analysis of chemosensory-focused
neuroepidemiologic studies using patient-oriented research (POR) methodology. Building upon preliminary
data evaluating prevalence and persistence of OD in a vulnerable minority population served by CUIMC, Dr.
Overdevest will develop the framework for a longitudinal cohort study within this multi-ethnic population. The
research in Aim 1 will investigate epidemiologic risk factors for primary and persistent OD following COVID-19
infection by evaluating OD with subjective functional domain and test-based objective tools. In Aim 2, he will
study the relationship between persistent OD and neurological, neurocognitive, and neuropsychiatric
functioning using validated measures from the multilingual NIH Toolbox assessment battery. He will then
extend this preliminary work into the realm of neuroimaging by leveraging existing local research infrastructure
and the expertise of his mentorship team to develop pilot data correlating features of OD and neurologic
outcomes with anatomic and inflammatory changes in the brain. These studies will inform strategies for
counseling the public about demographic risk factors for experiencing COVID-19 related OD, associate risks
for additional neurological disabilities, and provide the foundation for future investigation into imaging
modalities to evaluate the central processing of olfaction and monitor outcomes of clinical trials for OD
interventions.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD dementia><Address><Affect><Aged 65 and Over><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Anatomic Sites><Anatomic structures><Anatomy><Anosmia><Apoplexy><Autoimmune Diseases><Awareness><Biological Markers><Brain><Brain Inflammation><Brain Nervous System><Brain Vascular Accident><COVID anosmia><COVID associated anosmia><COVID crisis><COVID epidemic><COVID pandemic><COVID related anosmia><COVID smell loss><COVID-19><COVID-19 affected><COVID-19 anosmia><COVID-19 associated anosmia><COVID-19 associated smell loss><COVID-19 consequence><COVID-19 crisis><COVID-19 effect><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 impact><COVID-19 impacted><COVID-19 induced anosmia><COVID-19 infection><COVID-19 olfactory dysfunction><COVID-19 pandemic><COVID-19 period><COVID-19 predisposition><COVID-19 public health crisis><COVID-19 related anosmia><COVID-19 related olfactory dysfunction><COVID-19 related risk><COVID-19 risk><COVID-19 risk factor><COVID-19 smell loss><COVID-19 susceptibility><COVID-19 virus><COVID-19 virus infection><COVID-19 vulnerability><COVID-19 years><COVID-19-mediated anosmia><COVID-related smell loss><COVID19 infection><COVID19 virus><CV-19><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Cephalalgia><Cephalgia><Cephalodynia><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Chemicals><Clinical><Clinical Trials><CoV emergence><CoV-2><CoV2><Cognitive Discrimination><Cohort Studies><Competence><Concurrent Studies><Coronavirus Infectious Disease 2019><Coronavirus disease 2019 predisposition><Coronavirus disease 2019 susceptibility><Coronavirus disease 2019 vulnerability><Counseling><Cranial Pain><Cross Sectional Analysis><Cross-Sectional Analyses><Cross-Sectional Studies><Cross-Sectional Survey><Data><Data Analyses><Data Analysis><Data Base Management><Data Base Management Systems><Data Correlations><Database Management Systems><Degenerative Neurologic Disorders><Demographic Factors><Development><Diabetes Mellitus><Discrimination><Disease Frequency Surveys><Dizziness><Doctor of Philosophy><Dysfunction><Encephalitis><Encephalon><Entorhinal Area><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology><Epidemiology Research><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Evaluation><Fatigue><Foundations><Frequencies><Functional disorder><Future><Goals><Groups at risk><Gustation><Head Pain><Head and Neck Surgery><Headache><High Prevalence><Hospitals><Immune response><Immunological response><Impairment><Individual><Individuals from minority><Individuals of minority><Infection><Inflammatory><Intervention><Intervention Strategies><Investigation><K-Awards><K-Series Research Career Programs><Knowledge><Lack of Energy><Learning><Long-term cohort study><Longitudinal Studies><Longitudinal cohort study><Longterm cohort study><MDS-UPDRS><MDS-Unified Parkinson's Disease Rating Scale><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medical center><Memory><Mentors><Mentorship><Minority Groups><Minority People><Minority Population><Minority individual><Mission><Modality><Monitor><Movement Disorder Society Unified Parkinson's Disease Rating Scale><Multilingualism><NIDCD><NIH><NMR Imaging><NMR Tomography><Nasopharynx><National Institute on Deafness and Other Communication Disorders><National Institutes of Health><Nervous System Degenerative Diseases><Nervous System Physiology><Neural Degenerative Diseases><Neural degenerative Disorders><Neuro-epidemiology><Neurocognition><Neurocognitive><Neurodegenerative Diseases><Neurodegenerative Disorders><Neuroepidemiology><Neurologic><Neurologic Degenerative Conditions><Neurologic Dysfunctions><Neurologic function><Neurologic outcome><Neurological><Neurological disability><Neurological function><Neurological outcome><Neuropsychologies><Neuropsychology><New York><Nuclear Magnetic Resonance Imaging><Obesity><Olfaction><Olfactory Pathways><Olfactory dysfunction><Olfactory system><Otolaryngology><Outcome><PET><PET Scan><PET imaging><PETSCAN><PETT><Pathology><Patients><People at risk><Perception><Persons at risk><Ph.D.><PhD><Physicians><Physiopathology><Pilot Projects><Population><Populations at Risk><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Predictive Factor><Predisposed to COVID-19><Predisposed to 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2><SARSCoV2><Seizures><Sensory><Sensory Disorders><Sensory disabilities><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe Acute Respiratory Syndrome CoV disease><Severe Acute Respiratory Syndrome coronavirus disease><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 pandemic><Severe acute respiratory syndrome coronavirus 2 predisposition><Severe acute respiratory syndrome coronavirus 2 susceptibility><Severe acute respiratory syndrome coronavirus 2 vulnerability><Severe acute respiratory syndrome related corona virus 2><Severities><Smell><Smell Perception><Strategic Planning><Stroke><Structure><Study Type><Symptoms><Taste><Taste Perception><Testing><Thick><Thickness><Training><UPDRS><Unified Parkinson's Disease Rating Scale><United States><United States National Institutes of Health><Universities><Viral><Viral Diseases><Virus><Virus Diseases><Vulnerable Populations><Work><Wuhan coronavirus><Zeugmatography><above age 65><adiposity><after COVID-19 infection><after SARS-CoV-2 infection><after SARS-CoV2 infection><after age 65><after infection by SARS-CoV-2><after severe acute respiratory distress syndrome CoV-2 infection><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><anosmia associated with COVID-19><anosmia in 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syndrome coronavirus 2><≥65 years>