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Principal Investigator: James D Crapo
Organization: NATIONAL JEWISH HEALTH
Fiscal Year: 2024
Award: $922,055
Funding agency: National Heart Lung and Blood Institute
Chronic obstructive pulmonary disease (COPD) is a syndrome commonly defined by a single physiological feature–chronic airflow obstruction. To improve diagnosis and treatment of COPD, it is essential to divide this complex syndrome into biologically meaningful subgroups of COPD patients and to predict disease progression accurately within those subtypes. Our primary approaches to assess COPD progression will use physiology (i.e., FEV1 decline) and imaging (i.e., increased emphysema); however, we will also assess clinical characteristics (e.g., increased exacerbations) and epidemiology (e.g., increased mortality). We will apply imaging, physiology, epidemiology, transcriptomics, proteomics, metabolomics, epigenetics, and genetics to a 15-year longitudinal cohort of smokers to provide new insights into COPD progression. Longitudinal analysis of physiological and imaging data will provide valuable information regarding progression (or stability) of airflow obstruction, CT measurements of emphysema and airway disease, and clinical characteristics. Longitudinal analysis of Omics data will identify biomarkers of COPD progression within disease subtypes. Machine learning and network analysis of multiple Omics data will implicate pathobiological mechanisms for COPD progression. Genetic association analysis using existing whole genome sequencing (WGS) data will identify both rare and common genetic determinants of COPD progression. Integrating WGS with RNA-Seq, DNA methylation, metabolomics, and proteomics will also facilitate identification of functional variants within regions of genetic association.
Terms: <Address><Adverse Experience><Adverse event><Airway Disease><Ancillary Study><Annual Reports><Archives><Area><Award><Bio-Informatics><Bioinformatics><Biological Markers><Biological Specimen Banks><Biological Substance Banks><Bronchial-Dilating Agents><Bronchodilator Agents><Bronchodilators><CAT scan><COPD><COVID-19 infection><COVID-19 virus infection><COVID19 infection><CT X Ray><CT Xray><CT imaging><CT scan><Cause of Death><Certification><Cessation of life><Characteristics><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical><Clinical Data><Collaborations><Collection><Communication><Communities><Compensation><Complex><Computed Tomography><Computer Security><Contracting Opportunities><Contractor><Contracts><DNA Methylation><Data><Data Banks><Data Coordinating Center><Data Coordination Center><Data Science><Data Security><Data Set><Data Systems><Data awareness><Databanks><Death><Diagnosis><Diffusion><Disease Progression><Documentation><Educational workshop><Electronics><Emphysema><Enrollment><Ensure><Epidemiological data><Epidemiology><Epidemiology data><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Event><FEV1><FEV1%VC><Forced Expiratory Volume 1 Test><Forced Expiratory Volume in 1 Second><Funding><Future><Genes><Genetic><Genetic Determinism><Genetic analyses><Genomics><Goals><Grant><IRB><IRBs><IT Systems><Image><Information Systems><Information Technology Systems><Institutional Review Boards><International><Internet><Investigators><Journals><Laboratories><Link><Long-term Follow-up><Long-term cohort><Longitudinal cohort><Longterm Follow-up><Longterm cohort><Lung Function Tests><Machine Learning><Magazine><Manuscripts><Measurement><Measures><Medical History><Metadata><Methods><Molecular><Monitor><Multiomic Data><NHLBI><NIH><Names><National Heart, Lung, and Blood Institute><National Institutes of Health><Network Analysis><O element><O2 element><Observation research><Observation study><Observational Study><Observational research><Outcome><Oxygen><PFT/FEV1><Participant><Pathway Analysis><Patients><Peer Review><Personal Medical History><Personal Medical History Epidemiology><Persons><Phone><Physical Performance><Physiologic><Physiological><Physiology><Policies><Procedures><Proteomics><Protocol><Protocols documentation><PubMed><Publications><Pulmonary Emphysema><Pulmonary Function Test/Forced Expiratory Volume 1><Pulmonary function tests><QOL><Quality Control><Quality of life><Questionnaires><RNA Seq><RNA sequencing><RNAseq><Recommendation><Reporting><Research><Research Personnel><Research Resources><Researchers><Resolution><Resources><Risk Factors><SARS-CoV-2 infection><SARS-CoV2 infection><Scanning><Schedule><Scientific Publication><Scientist><Severe acute respiratory syndrome coronavirus 2 infection><Smoker><Specific qualifier value><Specified><Standardization><Subgroup><Support Contracts><Syndrome><System><TOPMed><Teleconferences><Telephone><Testing><Time><Tobacco Consumption><Tobacco use><Tomodensitometry><Training><Trans-Omics for Precision Medicine><Travel><United States National Institutes of Health><Update><Vaccination><Variant><Variation><Visit><WWW><Walking><Work><Workshop><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><adjudication><adjudicative process and procedure><airflow limitation><airflow obstruction><airway limitation><airway obstruction><analyzing longitudinal><bio-markers><biologic marker><biological specimen repository><biomarker><biomarker identification><biosample repository><biospecimen bank><biospecimen repository><catalyst><catscan><chest CT><chest computed tomography><chronic airflow limitation><chronic airflow obstruction><chronic airway obstruction><chronic obstructive pulmonary disorder><clinical center><clinical research site><clinical site><cohort><computed axial tomography><computer tomography><computerized axial tomography><computerized tomography><coronavirus disease 2019 infection><data deposition><data depository><data format><data management and coordinating center><data management center><data quality><data repository><data set repository><data sharing><data submission><database of Genotypes and Phenotypes><dataset repository><dbGaP><demographics><depository><diffused><diffuses><diffusing><diffusions><digital><disease subgroups><disease subtype><disorder subtype><electronic><electronic device><emphysematous><enroll><entire genome><epidemiologic><epidemiologic data><epidemiological><epigenetically><facilities for imaging><frailty><full genome><genetic analysis><genetic association><genetic determinant><genome sequencing><identification of biomarkers><identification of new biomarkers><image processing><imaging><imaging center><imaging facilities><imaging-related facilities><improved><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><information security><insight><long-term followup><longitudinal analysis><longterm followup><lumen dilator><machine based learning><marker identification><meeting><meetings><member><meta data><metabolism measurement><metabolomics><metabonomics><mortality><multiple omic data><name><named><naming><new technology><non-contrast CT><noncontrast CT><noncontrast computed tomography><novel technologies><obstructed airflow><obstructed airway><preservation><programs><quality assurance><recruit><repository><resolutions><respiratory airway obstruction><socio-economic><socio-economically><socioeconomically><socioeconomics><specimen bank><specimen repository><system security><tobacco product use><transcriptome sequencing><transcriptomic sequencing><transcriptomics><web><web site><website><whole genome><world wide web>