Document text
Principal Investigator: Justin D Russell
Organization: UNIVERSITY OF WISCONSIN-MADISON
Fiscal Year: 2024
Award: $138,735
Funding agency: National Institute of Mental Health
1. PROJECT SUMMARY/ABSTRACT
Candidate: I am presently a scientist in the BRAVE Research Center (BRC), within the Department of Psychiatry
at the University of Wisconsin (UW). Career Goals: I seek to identify neural mechanisms though which childhood
adversity can perturb typical development of biobehavioral affective systems in ways that effect enduring
psychiatric risk, as well as moderative ecological factors that may provide a foundation for evidence-based
clinical efforts with vulnerable youth. Career Development: I request support for mentored training to build
knowledge and skills in four areas pertinent to my career goals: (1) theory and analysis of functional brain
networks; (2) caregivers and caregiving as ecological moderators of the linkage between victimization and
psychopathology; (3) data-driven approaches to neurobehavioral analyses and (4) professional development as
an independent investigator. Research Project: The proposed work utilizes longitudinal, multimodal
assessment data from parent-child dyads participating in the Adolescent Brain Cognitive Development study
(N=11,875), and its Social Development sub-study (N=2,500). The primary aim is the evaluation of cross-
sectional and longitudinal changes in functional connectivity networks as mechanisms linking childhood adversity
(victimization) and caregiving practices to impairments in emotion regulation, a biobehavioral domain with
transdiagnostic relevance. First, I will extract robust functional network (static and dynamic) data from quality-
controlled ABCD resting state fMRI scans and evaluate these metrics (and their change across time) as
mediators in a structural equation model linking victimization and emotion regulation. Second, I will consider
main effects of caregiving practices (e.g., positive parenting) on functional network development, as well as
modulative impact on neurofunctional sequelae of victimization. Third, I will develop and evaluate a deep-
learning model predicting impairment in emotion regulation from neural and behavioral inputs, including regional
connectivity, caregiving practices, and exposure to victimization. These results will inform future applications
proposing independent research projects considering neurofunctional mechanisms linking adversity to
psychiatric risk in the context of granular assessment of caregiving practices, caregiver-child relationships, and
dynamics within the broader family system. Such findings may serve as the basis for developing targeted clinical
approaches translating ecological factors shown to moderate the biological and behavioral sequelae of
victimization. Environment: Activities in this proposal will be conducted at UW (BRC, Department of Psychiatry)
under the mentorship of esteemed scientists working in areas of affective and developmental neuroscience,
neural and behavioral sequelae of adversity, quantitative modeling of developmental processes, and machine
learning, led by Drs. Ryan Herringa, Seth Pollak, and Vikas Singh (respectively), each of whom possesses
extensive experience mentoring early career investigators.
Terms: <0-11 years old><Accounting><Address><Adolescent><Adolescent Youth><Adverse Experience><Adverse event><Affective><Anterior><Area><Behavior><Behavioral><Big Data><BigData><Biological><Biological Markers><Brain><Brain Nervous System><Brain region><Care Givers><Caregivers><Central Lobe><Characteristics><Child><Child Rearing><Child Youth><Childhood><Children (0-21)><Clinical><Connectionist Models><Cross Sectional Analysis><Cross-Sectional Analyses><Cross-Sectional Studies><Cross-Sectional Survey><Data><Development><Developmental Process><Diagnostic><Diagnostic Factor><Dimensions><Disease Frequency Surveys><Dorsal><Emotional><Emotions><Encephalon><Environment><Equation><Evaluation><Exhibits><Exposure to><Family><Foundations><Future><Goals><Impairment><Influentials><Insula><Insula of Reil><Investigation><Investigators><Island of Reil><Knowledge><Limbic System><Link><Machine Learning><Mediating><Mediation><Mediator><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Mentors><Mentorship><Modeling><Nature><Negotiating><Negotiation><Network Analysis><Neural Development><Neural Network Models><Neural Network Simulation><Neurosciences><Outcome><Parenting><Parenting behavior><Parents><Pathway Analysis><Pathway interactions><Pattern><Perceptrons><Phenotype><Prefrontal Cortex><Psychiatric Disease><Psychiatric Disorder><Psychiatric therapeutic procedure><Psychiatry><Psychological Health><Psychopathology><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Rest><Risk><Scientist><Social Development><Source><System><Theoretic Models><Theoretical model><Time><Training><Translating><Universities><Victimization><Vulnerable Populations><Wisconsin><Work><Youth><Youth 10-21><abnormal psychology><adolescent victimization><bio-markers><biobehavior><biobehavioral><biologic><biologic marker><biomarker><care giving><career><career development><caregiving><child and adolescent victimization><child victimization><childhood adversity><childrearing><cognitive development><computer based prediction><deep learning><deep learning based model><deep learning method><deep learning model><deep learning strategy><developmental><early adversity><early childhood adversity><early life adversity><emotion regulation><emotional regulation><evidence base><experience><fMRI scan><functional MRI scan><functional magnetic resonance imaging scan><insight><juvenile><juvenile human><kids><machine based learning><mental illness><multi-modality><multimodality><neural><neural circuit><neural circuitry><neural control><neural correlate><neural mechanism><neural network><neural regulation><neurobehavioral><neurocircuitry><neurodevelopment><neuromechanism><neuromodulation><neuromodulatory><neuroregulation><parent><pathway><pediatric><pediatric adversity><predictive modeling><psychiatric care><psychiatric illness><psychiatric therapy><psychiatric treatment><psychological disorder><skills><synaptic circuit><synaptic circuitry><theories><trend><vulnerable group><vulnerable individual><vulnerable people><youngster><youth victimization>