Document text
Principal Investigator: David S. Bradley
Organization: UNIVERSITY OF NORTH DAKOTA
Fiscal Year: 2024
Award: $1,998,812
Funding agency: National Institute of General Medical Sciences
Summary
This COBRE Phase 2 application proposes continued support of the UND Center for Excellence in Host-
Pathogen interaction (HPI). The long-term goal of this center is to develop a deeper understanding of host
responses to viral, bacterial and parasitic insults leading to acute and chronic inflammatory diseases. The vision
of this Center is to continue to inspire interest in the study of host-microbe interaction and perform paradigm-
shifting science that supports the notion that disease development is an interplay of the interaction between a
susceptible host, foreign insult and conducive microenvironment. In Phase 1 this center made significant
progress by expanding the number of investigators studying various aspects of infectious and inflammatory
diseases (from the initial group of 9 labs to now 18 labs). Since the funding of Phase 1 in 2016, this core group
of COBRE investigators has made significant contributions to the field by producing 169 publications,
$23,617,386 in extramural funding, and 74 speaking engagements (local, national and international). With the
project leader graduation success rate of 80% (4 out 6 investigators graduated with R01 funding) in Phase 1,
this Center will continue to promote research on host-microbe interaction by: 1) bringing together four young
investigators working cohesively in an integrative, collaborative, and multidisciplinary manner on research
encompassing extremely timely COVID-19 infection, intestinal dysbiosis in food allergy, gastrointestinal parasitic
infection, and viral interaction with respiratory epithelium; 2) enhance the innovative research capabilities of the
Center by supporting 3 existing Phase 1 Core facilities; 3) establishing a new Computational Data Analysis Core
to meet the emerging requirements of COBRE investigators; and 4) attract new investigators to the group by
supporting pilot grant mechanisms. The ultimate goal is to transition the HPI COBRE to a sustainable, well-
organized academic center which will serve as a conduit for increased interaction between investigators from
diverse backgrounds with a thematic interest in pursuing research on various aspects of host-microbe
interactions.
Terms: <Acute><Affect><Allergic to food><Allergy to food><Area><Bacterial Infections><Behavior Disorders><Big Data><BigData><Businesses><COBRE><COVID-19 infection><COVID-19 virus infection><COVID19 infection><Center of Biomedical Research Excellence><Centers of Research Excellence><Communicable Diseases><Communities><Core Facility><Data Analyses><Data Analysis><Degenerative Neurologic Disorders><Development><Disease><Disorder><EXTMR><Ensure><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Extramural><Extramural Activities><Faculty><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Focus Groups><Food Allergy><Food Hypersensitivity><Fostering><Funding><GI microbiota><Gastrointestinal microbiota><Generalized Growth><Genomics><Giardia><Goals><Grant><Growth><Health><Histology><Human><Image><Immune response><Immunological response><Individual><Infection><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Inflammation><Inflammatory><Interdisciplinary Research><Interdisciplinary Study><International><Intestinal><Intestines><Investigation><Investigators><Lamblia><Light><Mentors><Modern Man><Mucosa><Mucosal Tissue><Mucous Membrane><Multidisciplinary Collaboration><Multidisciplinary Research><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Parasites><Parasitic Diseases><Parasitic infection><Phase><Photoradiation><Predisposition><Process><Program Development><Publications><Qualifying><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Infrastructure><Research Personnel><Research Project Grants><Research Projects><Researchers><Respiratory Epithelium><Respiratory syncytial virus><SARS-CoV-2 infection><SARS-CoV2 infection><Science><Scientific Publication><Scientist><Self-Help Groups><Severe acute respiratory syndrome coronavirus 2 infection><Sight><Stream><Structure of respiratory epithelium><Support Groups><Surface><Susceptibility><Talents><Tissue Growth><Viral><Viral Diseases><Virus Diseases><Vision><airway epithelium><anti-cancer research><bacteria infection><bacterial disease><behavioral disorder><bowel><cancer research><career development><career fair><career networking><chronic inflammatory disease><coronavirus disease 2019 infection><data interpretation><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><developmental><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiota><epigenetically><equipment acquirement><equipment acquisition><equipment investment><equipment procurement><equipment purchase><equipment purchasing><experiment><experimental research><experimental study><experiments><flow cytophotometry><gastrointestinal><gastrointestinal microbial flora><gut commensal><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><host microbe association><host microbe relationship><host response><host-microbe interactions><host-microbial interactions><host-microorganism interactions><imaging><immune system response><immunoresponse><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><innovate><innovation><innovative><instrument acquisition><instrument investment><instrument procurement><instrument purchase><interest><intestinal flora><intestinal microbiota><intestinal microflora><intestinal tract microflora><microbial imbalance><microbiome><multidisciplinary><neurodegenerative illness><novel><ontogeny><parasite infection><pathogen><professional networking><programs><respiratory><respiratory tract epithelium><self help organization><speed networking><success><viral infection><virus infection><virus-induced disease><visual function>