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Principal Investigator: GABRIEL Alejandro DE ERAUSQUIN
Organization: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
Fiscal Year: 2024
Award: $8,610,822
Funding agency: National Institute on Aging
The science proposed in this program takes advantage of the unique scientific opportunity created by the
ongoing coronavirus pandemic, to study the interaction between a definable and time-limited risk-inducing
environmental event (exposure to the virus) and genomic variation on the occurrence of cognitive decline and
Alzheimer’s disease and related dementias (ADRD) in large cohorts of older adults from underrepresented
minorities in the USA and ancestral groups in Africa and South America. The investigators leading the program
have extensive experience in directing international consortia and longitudinal cohorts, including the creation
and follow up of an Amerindian cohort in the Andes region for longer than a decade. We have pilot
ascertainment of cognitive impairment end-points in newly recruited older adults of Amerindian ancestry. This
U19 will investigate the interactions between whole genome sequence genetic variations and COVID-19
infection and disease on the risk of cognitive decline and risk of ADRD in 4,300 individuals as part of newly
recruited cohorts in Texas, New York, Washington State, Ibadan (Nigeria), and Jujuy (Argentina). Participant
assessments will include neurological, cognitive, imaging and blood-based biomarker evaluations using
harmonized protocols and at 3 time points: within a few months of infection and 18 and 36 months afterwards.
We propose to answer this complex research question with 3 highly integrated Projects supported by equally
integrated Administrative, Clinical, Neuroimaging and Data Management/Statistics Cores. All projects involve
integrated multidisciplinary teams of investigators within a consortium of institutions including University of
Texas Health San Antonio, University of Texas Rio Grande Valley, Washington University School of Medicine,
Albert Einstein College of Medicine, University of Washington, University of Ibadan, the Ministry of Health of
the Province of Jujuy (Argentina) and the FULTRA Foundation (Argentina). Resources and study expertise will
be tightly coordinated across multiple sites and Cores, and integrated to the National Institute of Aging
Alzheimer’s Disease Sequencing Project and National Alzheimer’s Coordinating Center which will help ensure
optimal sharing of the acquire data and knowledge.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD dementia><AD related dementia><ADRD><APOE e4><APOE-ε4><APOEε4><Active Follow-up><Acute><Address><Admixture><Adult><Adult Human><Affect><Africa><African><African American><African American group><African American individual><African American people><African American population><African Americans><Afro American><Afroamerican><Age Years><Aged 65 and Over><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's and related dementias><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Amentia><Amerindian><Anosmia><Argentina><Brain><Brain Nervous System><Brain Vascular><CNS Nervous System><COVID anosmia><COVID associated anosmia><COVID disease severity><COVID related anosmia><COVID severity><COVID smell loss><COVID-19><COVID-19 anosmia><COVID-19 associated anosmia><COVID-19 associated smell loss><COVID-19 disease severity><COVID-19 exposure><COVID-19 induced anosmia><COVID-19 infection><COVID-19 olfactory dysfunction><COVID-19 predisposition><COVID-19 related anosmia><COVID-19 related olfactory dysfunction><COVID-19 severity><COVID-19 smell loss><COVID-19 susceptibility><COVID-19 virus><COVID-19 virus infection><COVID-19 vulnerability><COVID-19-mediated anosmia><COVID-related smell loss><COVID19 disease severity><COVID19 infection><COVID19 severity><COVID19 virus><CV-19><Central Nervous System><Cessation of life><Chicanas><Chicanos><Chronic><Clinical><CoV pandemic><CoV-2><CoV2><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complex><Coronavirus Infectious Disease 2019><Coronavirus disease 2019 predisposition><Coronavirus disease 2019 susceptibility><Coronavirus disease 2019 vulnerability><DNA><Data><Data Analyses><Data Analysis><Data Collection><Death><Dementia><Deoxyribonucleic Acid><Diet><Disease><Disorder><Disturbance in cognition><Emotional><Encephalon><Ensure><Epidemiology><Event><Exposure to><Foundations><Gene x Environment Interaction><Genetic><Genetic Diversity><Genetic Variation><Genome><Genotype><Guidelines><GxE interaction><Health><Hispanic><Hispanic Americans><Image><Impaired cognition><In Vitro><Individual><Induced pluripotent stem cell derived human neuron><Infection><Inflammation><Institution><International><Investigators><Knowledge><Latino Population><Latino group><Latino individual><Latino people><Latinos><Long COVID><Long COVID-19><Long coronavirus disease><Long coronavirus disease 2019><Long-term cohort><Longitudinal cohort><Longterm cohort><Lung><Lung Respiratory System><Mediating><Medicine><Mexican Americans><Moods><National Institute of Aging><National Institute on Aging><Native Americans><Nature><Nerve Degeneration><Neuraxis><Neurocognitive><Neurologic><Neurologic Manifestations><Neurologic Signs and Symptoms><Neurologic Symptoms><Neurological><Neurological Manifestations><Neurological Signs and Symptoms><Neuron Degeneration><New York><Nigeria><Obesity><Olfactory Cortex><Participant><Performance><Persons><Phase><Population><Predicting Risk><Predisposed to COVID-19><Predisposed to SARS-CoV-2><Predisposed to Severe acute respiratory syndrome coronavirus 2><Preventative strategy><Prevention strategy><Preventive strategy><Primary Senile Degenerative Dementia><Protocol><Protocols documentation><Province><Recovery><Research><Research Personnel><Research Resources><Researchers><Resources><Risk><Risk Factors><Risk Marker><Rural><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 disease severity><SARS-CoV-2 exposure><SARS-CoV-2 induced anosmia><SARS-CoV-2 infection><SARS-CoV-2 mediated anosmia><SARS-CoV-2 predisposition><SARS-CoV-2 severity><SARS-CoV-2 susceptibility><SARS-CoV-2 vulnerability><SARS-CoV2><SARS-CoV2 exposure><SARS-CoV2 infection><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Sampling><Science><Secondary Prevention><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 exposure><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 predisposition><Severe acute respiratory syndrome coronavirus 2 susceptibility><Severe acute respiratory syndrome coronavirus 2 vulnerability><Severe acute respiratory syndrome related corona virus 2><Severities><Site><Smoking><South America><Symptoms><Testing><Texas><Time><Traditional Medicine><Underrepresented Ethnic Minority><Underrepresented Minority><Universities><Variant><Variation><Viral><Virus><Washington><Wuhan coronavirus><above age 65><active followup><adiposity><adulthood><after COVID-19 infection><after SARS-CoV-2 infection><after SARS-CoV2 infection><after age 65><after infection by SARS-CoV-2><after severe acute respiratory distress syndrome CoV-2 infection><age 65 and greater><age 65 and older><age 65 or older><age > 65><age group><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><alzheimer risk><amnestic mild cognitive impairment><anosmia associated with COVID-19><anosmia in COVID-19><anosmia with COVID-19><anosphrasia><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><biomarker evaluation><blood-based biomarker><blood-based marker><cerebral vascular><cerebro-vascular><cerebrovascular><chronic COVID><chronic COVID-19><chronic novel coronavirus disease 2019><cognitive dysfunction><cognitive loss><cohort><college><collegiate><coronavirus disease 2019><coronavirus disease 2019 disease severity><coronavirus disease 2019 exposure><coronavirus disease 2019 infection><coronavirus disease 2019 severity><coronavirus disease 2019 virus><coronavirus disease severity><coronavirus disease-19><coronavirus disease-19 virus><coronavirus infectious disease-19><coronavirus pandemic><corpulence><data interpretation><data management><data quality><data sharing><design><designing><diets><early onset><entire genome><environment effect on gene><epidemiologic><epidemiological><experience><experiment><experimental research><experimental study><experiments><exposure to COVID-19><exposure to SARS-CoV-2><exposure to SARS-CoV2><exposure to Severe acute respiratory syndrome coronavirus 2><exposure to coronavirus disease 2019><follow up><follow-up><followed up><following COVID-19 infection><following SARS-CoV-2 infection><following SARS-CoV2 infection><following infection by SARS-CoV-2><following severe acute respiratory distress syndrome CoV-2 infection><followup><forecasting risk><full genome><gene environment interaction><genetic predictors><genome sequencing><genomic variation><hCoV19><hiPSC-derived neurons><human iPSC-derived sensory neuron><human old age (65+)><iPSC-derived human neuron><imaging><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><long haul COVID><long haul COVID-19><long haul coronavirus disease><long haul coronavirus disease 2019><long-hauler COVID><long-hauler COVID-19><long-hauler coronavirus disease 2019><long-hauler syndrome><long-term COVID><long-term COVID-19><long-term coronavirus disease><long-term coronavirus disease 2019><longitudinal course><longterm COVID><longterm COVID-19><longterm coronavirus disease><longterm coronavirus disease 2019><loss of smell><marker evaluation><medical college><medical schools><multidisciplinary><nCoV2><neural><neural degeneration><neural imaging><neural manifestation><neuro-imaging><neurodegeneration><neurodegenerative><neuroimaging><neurological degeneration><neurological imaging><neuron toxicity><neuronal degeneration><neuronal toxicity><neuropsychiatric><neuropsychiatric sequelae in COVID-19><neuropsychiatric sequelae of COVID-19><neuropsychiatric sequelae of SARS-CoV-2><neuropsychiatric sequelae of coronavirus disease-19><neuropsychiatry><neurotoxicity><old age><older adult><older adulthood><olfactory dysfunction following COVID-19><olfactory dysfunction following SARS-CoV-2><olfactory dysfunction in COVID-19><olfactory dysfunction in SARS-CoV-2><olfactory loss><over 65 years><persistent COVID-19><post COVID syndrome><post COVID-19 syndrome><post SARS-CoV-2 infection><post acute COVID syndrome><post acute COVID-19><post acute COVID-19 syndrome><post acute SARS-CoV-2><post acute coronavirus disease 2019><post acute coronavirus disease 2019 syndrome><post acute coronavirus disease syndrome><post acute severe acute respiratory syndrome coronavirus 2><post coronavirus disease 2019 syndrome><post coronavirus disease syndrome><post-acute phases of COVID-19><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><predisposed to Coronavirus disease 2019><previous COVID-19 infection><previous SARS-CoV-2 infection><previous SARS-CoV2 infection><previous severe acute respiratory distress syndrome CoV-2 infection><primary degenerative dementia><prior COVID-19 infection><prior SARS-CoV-2 infection><prior SARS-CoV2 infection><prior severe acute respiratory distress syndrome CoV-2 infection><programs><prolonged COVID-19 symptoms><pulmonary><recruit><resilience><resilience factor><resiliency factor><resilient><respiratory><risk prediction><risk predictions><risk predictor><risk predictors><school of medicine><senile dementia of the Alzheimer type><severe acute respiratory syndrome coronavirus 2 disease severity><severe acute respiratory syndrome coronavirus 2 severity><smell loss associated with COVID-19><statistics><susceptible to COVID-19><susceptible to Coronavirus disease 2019><susceptible to SARS-CoV-2><susceptible to Severe acute respiratory syndrome coronavirus 2><treatment strategy><under-representation of minorities><under-represented minority><underrepresentation of minorities><variant of interest><vulnerable to COVID-19><vulnerable to Coronavirus disease 2019><vulnerable to SARS-CoV-2><vulnerable to Severe acute respiratory syndrome coronavirus 2><whole genome><≥65 years>