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Principal Investigator: Mary Elizabeth Ruth Hartnett
Organization: STANFORD UNIVERSITY
Fiscal Year: 2024
Award: $265,835
Funding agency: National Eye Institute
PROJECT SUMMARY
Age related macular degeneration (AMD) is a leading cause of vision loss in individuals over 55 years of age
and is increasing as the world population becomes older. Treatment options for early AMD are limited and,
therefore, vision will become increasingly threatened in the elderly population. Evidence from observational
studies suggest that whole foods, Mediterranean diets and low glycemic load (LG) diets are associated with
less progression of AMD, suggesting a cost-effective approach to slow AMD progression. The goal of this
project is to assess feasibility aims for dietary intervention in a non-diabetic AMD cohort with early stage
disease and to plan a future large, multicenter study that will compare LG-Mediterranean dietary intervention to
standard diet. Our aims are to: 1) demonstrate feasibility of behavioral intervention to change dietary intake in
subjects with intermediate AMD from consuming a typical Western diet to a LG, Mediterranean diet; 2) assess
the feasibility of obtaining sensitive retinal images and sdOCTs and to explore assays (metabolomic markers,
complement factors, gut barrier dysfunction and dysbiosis, AGEs, and oxycholesterols (e.g. 7-ketocholesterol)
for consideration as non-disease biomarkers for a future UG1; 3) develop a protocol for a future multicenter
study and a Manual of Procedures. Our team is cross-disciplinary including experts in behavioral dietary
intervention, endocrinologists, retinal specialists, clinical trial experts and leaders of large consortia of AMD
intervention studies in the US and Europe. Innovative aspects of the planning study include: to assess the
willingness of an elderly population without diabetes to adopt a dietary intervention; to use continuous glucose
monitoring as a coaching tool for the cohort and to learn about the sensitivity of continuous glucose monitoring
for the future multicenter study; to explore ophthalmologic and non-ophthalmologic biomarkers for the future
study; and to perform feasibility studies on systemic biomarkers relevant to the pathophysiology of AMD and
that may improve sensitivity of outcome measures in the future multicenter clinical trial.
Terms: <3 beta-hydroxycholest-5-en-7-one><3beta-hydroxy-5-cholestene-7-one><5-cholesten-3 beta-ol-7-one><7-ketocholesterol><7-oxocholesterol><Address><Adopted><Advanced Glycation End Products><Advanced Glycosylation End Products><Affect><Age><Age Years><Age related macular degeneration><Age-Related Maculopathy><Animal Model><Animal Models and Related Studies><Assay><Basic Research><Basic Science><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Bioassay><Biological Assay><Biological Markers><Blindness><Blood Glucose><Blood Sugar><Body Tissues><Clinical Trials><Complement><Complement Proteins><Conditioning Therapy><Consumption><Continuous Glucose Monitor><D-Glucose><Deposit><Deposition><Development><Dextrose><Diabetes Mellitus><Diet><Dietary Intervention><Dietary intake><Disease><Disorder><Dysfunction><Elderly><Endocrinologist><Enrollment><Environment><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology Research><Europe><Fasting><Feasibility Studies><Food><Functional disorder><Future><Glucose><Glycated Hemoglobins><Glycohemoglobin A><Glycosylated Hemoglobin><Glycosylated hemoglobin A><Goals><Grant><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Hemoglobin A(1)><Human><Individual><Intervention><Intervention Strategies><Intervention Studies><Learning><Legal Blindness><Lipids><Manuals><Measures><Mediterranean Diet><Modern Man><Multi-Institutional Clinical Trial><Multi-center clinical trial><Multi-center studies><Multi-site clinical trial><Multicenter Studies><Multicenter clinical trial><Multisite clinical trial><NIH><National Institutes of Health><Nutrition Interventions><Nutritional Interventions><Obesity><Observation research><Observation study><Observational Study><Observational research><Organization Charts><Outcome Measure><Patients><Physiopathology><Population><Procedures><Protocol><Protocols documentation><Quality Control><Research><Research Support><Retina><Retrospective Studies><Risk><Risk Factors><Risk Reduction><Sample Size><Sight><Site><Specialist><Techniques><Testing><Time><Tissues><Unhealthy Diet><United States National Institutes of Health><Vision><adiposity><advanced age><advanced glycation endproduct><advanced glycosylation endproduct><age dependent macular degeneration><age induced macular degeneration><age related macular disease><age related macular dystrophy><ages><behavior intervention><behavioral intervention><bio-markers><biologic marker><biomarker><cardiovascular disease risk><cardiovascular disorder risk><cohort><complementation><continuous blood glucose monitor><continuous blood sugar monitor><continuous glucose measurement><continuous sugar monitor><corpulence><cost effective><data management><data tools><design><designing><developmental><diabetes><diet intervention><dietary><diets><dysbacteriosis><dysbiosis><dysbiotic><enroll><epidemiologic investigation><epidemiology study><experiment><experimental research><experimental study><experiments><fasted><fasts><fundus imaging><geriatric><hemoglobin A1c><improved><innovate><innovation><innovative><insulin sensitivity><intervention research><interventional research><interventional strategy><interventional study><interventions research><legally blind><measurable outcome><metabolic profile><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><microbial imbalance><microbiome><model of animal><non-diabetic><nondiabetic><organizational structure><outcome measurement><oxidation><pathophysiology><poor diet><prospective><recruit><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><retina imaging><retinal imaging><risk-reducing><senile macular disease><senior citizen><tool><vision loss><visual function><visual loss><western diet><western-style diet><western-type diet><willingness>