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Principal Investigator: Samira Asgari
Organization: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Fiscal Year: 2024
Award: $190,125
Funding agency: National Institute on Minority Health and Health Disparities
Prior research has shown that both environmental factors (e.g., healthcare access, socioeconomic status, and lifestyle) and human genetic variation influence susceptibility to infectious diseases. However, systematic analysis of how both sociodemographic and genetic factors contribute to differences in infectious disease susceptibility remains limited. Addressing this gap is important for improving clinical care and informing public health strategies.
To this end, we will leverage genetic, electronic health record, and survey data from the All of Us biobank to test the hypothesis that human genetic factors contribute to differences in infectious disease susceptibility across genetic similarity groups independently of sociodemographic variables through the following aims:
Aim 1: To identify demographic, socioeconomic, behavioral, and environmental factors associated with infectious disease susceptibility. In this aim, we will perform a comprehensive assessment of 227 demographic, socioeconomic, behavioral, and environmental variables, collected through All of Us surveys, on the prevalence of 336 infectious disease phenotypes across clusters of individuals who share a significant degree of genetic similarity. At the end of this aim, we will identify infectious diseases and associated contextual variables that are enriched or depleted in specific clusters.
Aim 2: To identify human genetic factors associated with infectious disease susceptibility. In this aim, we will perform in-depth analyses of genetic variants that can be associated with infectious disease susceptibility. This aim will lead to the discovery of novel infectious disease susceptibility loci and risk variants. We will perform in silico functional analysis to gain insight to the function of these variants.
In the short term, this study will result in identifying sociodemographic and genetic risk factors that underlie susceptibility to infectious diseases and clarify their relative contributions. Moreover, this project enhances our understanding of infectious disease biology and the genetic factors that affect interindividual variability in susceptibility to specific pathogens. In the long term, the results of this project can help the development of new public health policies or new diagnostic tests or drugs for infectious diseases.
Terms: <AIDS Virus><AIDS/HIV><Accounting><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Affect><Airway infections><Behavioral><Biology><COVID disparity><COVID related disparity><COVID-19 disparity><COVID-19 induced disparity><COVID-19 related disparity><Categories><Code><Coding System><Communicable Diseases><Communities><Complex><Data><Data Set><Development><Diagnostic tests><Disease><Disorder><Disparities><Disparity><Drugs><Economics><Electronic Health Record><Environmental Factor><Environmental Risk Factor><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology Research><Equity><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Future><GWA study><GWAS><Gene Expression><Gene variant><Genetic><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Risk><Genetic Susceptibility><Genetic analyses><Genetic predisposing factor><Genetic propensity><Genome><Genomic Segment><Genotype><Geography><Goals><HIV><HIV/AIDS><Health Policy><Hepatitis><History><Human><Human Genetics><Human Immunodeficiency Viruses><Inequality><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Inherited Predisposition><Inherited Susceptibility><Investigators><Justice><LAV-HTLV-III><Life Style><Lifestyle><Lymphadenopathy-Associated Virus><M tuberculosis infection><M. tb infection><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Malaria><Medication><Modern Man><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Names><Orphan Disease><Paludism><Participant><Patient Self-Report><Pharmaceutical Preparations><Plasmodium Infections><Population><Population Group><Population Heterogeneity><Position><Positioning Attribute><Predisposition><Predisposition gene><Prevalence><Public Health><Race><Races><Rare Diseases><Rare Disorder><Recording of previous events><Research Personnel><Research Resources><Researchers><Residual><Residual state><Resources><Respiratory Infections><Respiratory Tract Infections><Risk Factors><Risk-associated variant><Role><Self-Report><Sepsis><Sexually Transmitted Diseases><Sexually Transmitted Disorder><Sexually Transmitted Infection><Shapes><Societies><Socio-economic status><Socioeconomic Status><Stratification><Structural Racism><Structure><Survey Instrument><Surveys><Susceptibility><Susceptibility Gene><TB infection><Testing><Tuberculosis><Variant><Variation><Venereal Diseases><Venereal Disorders><Venereal Infections><Virus-HIV><Work><access to health care><access to healthcare><accessibility of health care><accessibility to health care><accessibility to healthcare><admixture mapping><allele variant><allelic variant><biobank><biorepository><blood infection><bloodstream infection><burden of disease><burden of illness><clinical care><cohort><coronavirus disease 2019 disparity><developmental><differences due to race><differences in race><differs by race><differs in race><disease burden><disease phenotype><disparities in COVID><disparities in COVID-19><disparities in race><disparity due to COVID-19><disparity due to race><disparity in ethnic><disparity in health><disseminated TB><disseminated tuberculosis><diverse populations><drug/agent><economic><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><entire genome><environmental risk><epidemiologic investigation><epidemiology study><ethnic based disparity><ethnic difference><ethnic disadvantage><ethnic disparity><ethnic inequality><ethnic inequity><ethnic minority><ethnic subgroup><ethnicity difference><ethnicity disparity><ethnicity group><experience><full genome><genetic analysis><genetic etiology><genetic mechanism of disease><genetic risk factor><genetic variant><genetic vulnerability><genetically predisposed><genome segment><genome sequencing><genome wide association><genome wide association scan><genome wide association studies><genome wide association study><genomewide association scan><genomewide association studies><genomewide association study><genomic region><genomic variant><health care access><health care availability><health care policy><health care service access><health care service availability><health disparity><healthcare access><healthcare accessibility><healthcare availability><healthcare policy><healthcare service access><healthcare service availability><heterogeneous population><histories><human genomics><improved><in silico><inequality due to race><inequity due to race><infection due to Mycobacterium tuberculosis><inherited factor><insight><inter-individual variability><inter-individual variation><interindividual variability><interindividual variation><low SES><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><name><named><naming><new diagnostics><new drug treatments><new drugs><new marker><new pharmacological therapeutic><new therapeutics><new therapy><next generation diagnostics><next generation therapeutics><novel><novel biomarker><novel diagnostics><novel drug treatments><novel drugs><novel marker><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><orphan disorder><pathogen><population diversity><predisposing gene><race based differences><race based disparity><race based inequality><race based inequity><race differences><race disparity><race related differences><race related disparity><race related inequality><race related inequity><racial><racial background><racial difference><racial disparity><racial inequality><racial inequity><racial minority><racial origin><racially different><racially unequal><rare allele><rare mutation><rare variant><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sexually acquired infection><social disadvantage><social disparities><social inequality><social role><socio-demographic factors><socio-demographic variables><socio-demographics><socio-economic><socio-economic position><socio-economically><sociodemographic factors><sociodemographic variables><sociodemographics><socioeconomic position><socioeconomically><socioeconomics><susceptibility allele><susceptibility locus><susceptibility variant><tuberculosis infection><tuberculous spondyloarthropathy><whole genome><whole genome association analysis><whole genome association studies><whole genome association study>