Document text
Principal Investigator: Melanie Lynn Kornides
Organization: UNIVERSITY OF PENNSYLVANIA
Fiscal Year: 2024
Award: $592,790
Funding agency: National Cancer Institute
Project Summary
Background: Misinformation on social media, or the sharing of false or incomplete information without intent
to cause harm, is contributing to vaccine hesitancy among parents and impeding uptake of the HPV vaccine
among adolescents in the United States. Innovative communication strategies that can be rapidly developed
and deployed to correct evolving misinformation about HPV vaccine on social media and increase uptake of
HPV vaccine are needed. Hypothesis: We hypothesize that theory-based corrective messages directly
addressing the content of misinformation will improve HPV vaccine series initiation and completion as
compared to general corrective messages and a non-message control group. Proposal: We will efficiently
identify recently circulating misinformation on social media using natural language processing (NLP) methods,
develop and test a theory-based corrective messaging tool using a validated message testing protocol, and
assess the efficacy of the tool on increasing HPV vaccine series initiation and completion among adolescents
in an online, block-randomized controlled trial with three arms and longitudinal follow-up. Participants (n=2500)
will be parents of adolescents ages 8-11 recruited from social media and followed up over a 12-month period.
Importance and Innovation: If successful, in addition to improving HPV vaccination uptake, the methods from
this study have the potential to be adapted to address other forms of misinformation swiftly and efficiently in
public health such as that surrounding COVID19, childhood vaccinations, or cancer prevention and treatment
strategies.
Terms: <0-11 years old><11 year old><11 years of age><3-arm study><Active Follow-up><Address><Adolescent><Adolescent Youth><Age><Attitude><Belief><COVID-19><CV-19><Child><Child Youth><Childhood><Children (0-21)><Communication><Control Groups><Coronavirus Infectious Disease 2019><Data><Deception><Education><Educational aspects><English Language><Enrollment><Environment><Exposure to><Facebook><Female><Fostering><Frequencies><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Goals><HPV><HPV Vaccination><HPV Vaccine><HPV vaccination acceptability><HPV vaccination acceptance><HPV vaccination confidence><HPV vaccination uptake><HPV vaccine acceptability><HPV vaccine acceptance><HPV vaccine confidence><HPV vaccine uptake><Health><Health behavior><Hearing><Human Papilloma Virus><Human Papilloma Virus Vaccination><Human Papilloma Virus Vaccine><Human Papillomavirus><Human Papillomavirus Vaccination><Human papillomavirus Vaccine><Individual><Industry><Infectious Human Wart Virus><Injury><Intervention><Intervention Strategies><Media Campaign><Methods><Misinformation><Movement><Natural Language Processing><Parents><Participant><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Protocol><Protocols documentation><Public Health><Randomized><Randomized, Controlled Trials><Recruitment Activity><Reporting><Risk><Safety><Sampling><Screening for cancer><Series><Survey Instrument><Surveys><Testing><TikTok><Tube><Twitter><United States><Vaccinated><Vaccination><Vaccines><Vendor><Work><accept HPV vaccination><accept HPV vaccine><accept human papilloma virus vaccination><accept human papilloma virus vaccine><accept vaccination><accept vaccine><active followup><active recruitment><age 11 years><ages><arm><body movement><booster dose><booster shot><booster vaccine><cancer prevention><comparable efficacy><comparative efficacy><compare efficacy><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><determine efficacy><early cancer detection><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><efficacy testing><eleven year old><eleven years of age><enroll><evaluate efficacy><examine efficacy><falls><financial incentive><financial reward><follow up><follow-up><followed up><followup><geographic site><health related behavior><hesitant to vaccination><human papilloma virus vaccination acceptability><human papilloma virus vaccination acceptance><human papilloma virus vaccination confidence><human papilloma virus vaccination uptake><human papilloma virus vaccine acceptability><human papilloma virus vaccine acceptance><human papilloma virus vaccine confidence><human papilloma virus vaccine uptake><improved><injuries><innovate><innovation><innovative><interventional strategy><juvenile><juvenile human><kids><male><media consumption><media use><monetary incentive><natural language understanding><new approaches><non vaccinated><not vaccinated><novel approaches><novel strategies><novel strategy><pandemic><pandemic disease><parent><pediatric><primary outcome><randomisation><randomization><randomized control trial><randomly assigned><rapid method><rapid technique><recruit><refuse vaccination><refuse vaccine><screening cancer patients><sex><side effect><social media><theories><three-arm study><tool><treatment strategy><unvaccinated><vaccination acceptability><vaccination acceptance><vaccination confidence><vaccination hesitancy><vaccination refusal><vaccination uptake><vaccination willingness><vaccine acceptability><vaccine acceptance><vaccine boost><vaccine confidence><vaccine hesitancy><vaccine hesitant><vaccine refusal><vaccine uptake><vaccine willingness><wart virus><youngster>